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UniProtKB/Swiss-Prot entry Q816G3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH2_BACCR
Primary accession number Q816G3
Secondary accession numbers None
Integrated into Swiss-Prot on June 21, 2004
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 43)
Name and origin of the protein
Protein name L-lactate dehydrogenase 2
Synonyms L-LDH 2
EC 1.1.1.27
Gene name
Name: ldh2
OrderedLocusNames: BC_4870
From
Bacillus cereus (strain ATCC 14579 / DSM 31) [TaxID: 226900] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus; Bacillus cereus group.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature01582; PubMed=12721630 [NCBI, ExPASy, EBI, Israel, Japan]
Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G., Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.;
"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis.";
Nature 423:87-91(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016877; AAP11769.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_834568.1; -.
3D structure databases
HSSP P00344; 2LDB. [HSSP ENTRY / PDB]
ModBase Q816G3.
Enzyme and pathway databases
BioCyc BCER226900:BC_4870-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS Q816G3.
Genome annotation databases
GeneID 1207212; -.
GenomeReviews AE016877_GR; BC_4870.
KEGG bce:BC4870; -.
Phylogenomic databases
HOGENOM Q816G3; -.
Genome annotation databases
CMR Q816G3; BC_4870.
Other
ProtoNet Q816G3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   314  314     L-lactate dehydrogenase 2. PRO_0000168322
NP_BIND   14    42  29     NAD (By similarity). 
ACT_SITE   178   178        Proton acceptor (By similarity). 
BINDING   91    91        Substrate (By similarity). 
BINDING   123   123        NAD or substrate (By similarity). 
BINDING   154   154        Substrate (By similarity). 
BINDING   232   232        Substrate (By similarity). 
MOD_RES   223   223        Phosphotyrosine (By similarity). 
Sequence information
Length: 314 AA [This is the length of the unprocessed precursor] Molecular weight: 34583 Da [This is the MW of the unprocessed precursor] CRC64: 5629A9FA2579FD81 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKKGINRVVL VGTGAVGCSY AYSMINQGVA EEFVLVDVNE AKAEGEAMDL SHAVPFSPSP 

        70         80         90        100        110        120 
TKVWSGSYAD CKDADLVVIT AGLPQKPGET RLDLVEKNTK IFKQIVRGIM DSGFDGIFLI 

       130        140        150        160        170        180 
ATNPVDILTY VTWKESGLPK ERVIGSGTTL DSARFRYMLG DYLDVDPRNV HAYIVGEHGD 

       190        200        210        220        230        240 
TELPVWSHAT IGVQKLETIL ANNEQYKQED LDKIFENVRD AAYQVIERKG ATYYGIGMSL 

       250        260        270        280        290        300 
LRVTKAILNN ENSVLTVSAY LEGQYGEKDA YVGVPAVINR EGVREIVELE LNEDEKAKFA 

       310 
HSVKVLKETM APVL
Q816G3 in FASTA format

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