[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, DNA-BINDING, DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
DOI=10.1016/S0092-8674(03)00393-3; PubMed=12787504 [NCBI, ExPASy, EBI, Israel, Japan]
Mitsui K.,
Tokuzawa Y.,
Itoh H.,
Segawa K.,
Murakami M.,
Takahashi K.,
Maruyama M.,
Maeda M.,
Yamanaka S.;
"The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells.";
Cell 113:631-642(2003).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
STRAIN=129/Ola;
TISSUE=Embryonic stem cell;
DOI=10.1016/S0092-8674(03)00392-1; PubMed=12787505 [NCBI, ExPASy, EBI, Israel, Japan]
Chambers I.,
Colby D.,
Robertson M.,
Nichols J.,
Lee S.,
Tweedie S.,
Smith A.;
"Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.";
Cell 113:643-655(2003).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND DEVELOPMENTAL STAGE.
STRAIN=FVB;
TISSUE=Embryonic stem cell;
DOI=10.1016/S1567-133X(03)00005-X; PubMed=12609610 [NCBI, ExPASy, EBI, Israel, Japan]
Wang S.-H.,
Tsai M.-S.,
Chiang M.-F.,
Li H.;
"A novel NK-type homeobox gene, ENK (early embryo specific NK), preferentially expressed in embryonic stem cells.";
Gene Expr. Patterns 3:99-103(2003).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
STRAIN=C57BL/6;
DOI=10.1002/dvdy.20034; PubMed=15108323 [NCBI, ExPASy, EBI, Israel, Japan]
Hart A.H.,
Hartley L.,
Ibrahim M.,
Robb L.;
"Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human.";
Dev. Dyn. 230:187-198(2004).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6J;
TISSUE=Embryonic stem cell;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P.,
Kasukawa T.,
Katayama S.,
Gough J.,
Frith M.C.,
Maeda N.,
Oyama R.,
Ravasi T.,
Lenhard B.,
Wells C.,
Kodzius R.,
Shimokawa K.,
Bajic V.B.,
Brenner S.E.,
Batalov S.,
Forrest A.R.,
Zavolan M.,
Davis M.J.,
Wilming L.G., ![]()
Aidinis V.,
Allen J.E.,
Ambesi-Impiombato A.,
Apweiler R.,
Aturaliya R.N.,
Bailey T.L.,
Bansal M.,
Baxter L.,
Beisel K.W.,
Bersano T.,
Bono H.,
Chalk A.M.,
Chiu K.P.,
Choudhary V.,
Christoffels A.,
Clutterbuck D.R.,
Crowe M.L.,
Dalla E.,
Dalrymple B.P.,
de Bono B.,
Della Gatta G.,
di Bernardo D.,
Down T.,
Engstrom P.,
Fagiolini M.,
Faulkner G.,
Fletcher C.F.,
Fukushima T.,
Furuno M.,
Futaki S.,
Gariboldi M.,
Georgii-Hemming P.,
Gingeras T.R.,
Gojobori T.,
Green R.E.,
Gustincich S.,
Harbers M.,
Hayashi Y.,
Hensch T.K.,
Hirokawa N.,
Hill D.,
Huminiecki L.,
Iacono M.,
Ikeo K.,
Iwama A.,
Ishikawa T.,
Jakt M.,
Kanapin A.,
Katoh M.,
Kawasawa Y.,
Kelso J.,
Kitamura H.,
Kitano H.,
Kollias G.,
Krishnan S.P.,
Kruger A.,
Kummerfeld S.K.,
Kurochkin I.V.,
Lareau L.F.,
Lazarevic D.,
Lipovich L.,
Liu J.,
Liuni S.,
McWilliam S.,
Madan Babu M.,
Madera M.,
Marchionni L.,
Matsuda H.,
Matsuzawa S.,
Miki H.,
Mignone F.,
Miyake S.,
Morris K.,
Mottagui-Tabar S.,
Mulder N.,
Nakano N.,
Nakauchi H.,
Ng P.,
Nilsson R.,
Nishiguchi S.,
Nishikawa S.,
Nori F.,
Ohara O.,
Okazaki Y.,
Orlando V.,
Pang K.C.,
Pavan W.J.,
Pavesi G.,
Pesole G.,
Petrovsky N.,
Piazza S.,
Reed J.,
Reid J.F.,
Ring B.Z.,
Ringwald M.,
Rost B.,
Ruan Y.,
Salzberg S.L.,
Sandelin A.,
Schneider C.,
Schoenbach C.,
Sekiguchi K.,
Semple C.A.,
Seno S.,
Sessa L.,
Sheng Y.,
Shibata Y.,
Shimada H.,
Shimada K.,
Silva D.,
Sinclair B.,
Sperling S.,
Stupka E.,
Sugiura K.,
Sultana R.,
Takenaka Y.,
Taki K.,
Tammoja K.,
Tan S.L.,
Tang S.,
Taylor M.S.,
Tegner J.,
Teichmann S.A.,
Ueda H.R.,
van Nimwegen E.,
Verardo R.,
Wei C.L.,
Yagi K.,
Yamanishi H.,
Zabarovsky E.,
Zhu S.,
Zimmer A.,
Hide W.,
Bult C.,
Grimmond S.M.,
Teasdale R.D.,
Liu E.T.,
Brusic V.,
Quackenbush J.,
Wahlestedt C.,
Mattick J.S.,
Hume D.A.,
Kai C.,
Sasaki D.,
Tomaru Y.,
Fukuda S.,
Kanamori-Katayama M.,
Suzuki M.,
Aoki J.,
Arakawa T.,
Iida J.,
Imamura K.,
Itoh M.,
Kato T.,
Kawaji H.,
Kawagashira N.,
Kawashima T.,
Kojima M.,
Kondo S.,
Konno H.,
Nakano K.,
Ninomiya N.,
Nishio T.,
Okada M.,
Plessy C.,
Shibata K.,
Shiraki T.,
Suzuki S.,
Tagami M.,
Waki K.,
Watahiki A.,
Okamura-Oho Y.,
Suzuki H.,
Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
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[6]
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FUNCTION.
DOI=10.1038/sj.cr.7290193; PubMed=14728807 [NCBI, ExPASy, EBI, Israel, Japan]
Pan G.J.,
Pei D.Q.;
"Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog.";
Cell Res. 13:499-502(2003).
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[7]
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DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
DOI=10.1016/j.modgep.2005.03.001; PubMed=15939376 [NCBI, ExPASy, EBI, Israel, Japan]
Yamaguchi S.,
Kimura H.,
Tada M.,
Nakatsuji N.,
Tada T.;
"Nanog expression in mouse germ cell development.";
Gene Expr. Patterns 5:639-646(2005).
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[8]
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FUNCTION, AND DNA-BINDING.
DOI=10.1074/jbc.M407847200; PubMed=15502159 [NCBI, ExPASy, EBI, Israel, Japan]
Pan G.,
Pei D.;
"The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus.";
J. Biol. Chem. 280:1401-1407(2005).
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[9]
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SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
DOI=10.1016/j.mod.2004.08.008; PubMed=15582778 [NCBI, ExPASy, EBI, Israel, Japan]
Hatano S.Y.,
Tada M.,
Kimura H.,
Yamaguchi S.,
Kono T.,
Nakano T.,
Suemori H.,
Nakatsuji N.,
Tada T.;
"Pluripotential competence of cells associated with Nanog activity.";
Mech. Dev. 122:67-79(2005).
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[10]
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INDUCTION.
DOI=10.1038/ncb1211; PubMed=15619621 [NCBI, ExPASy, EBI, Israel, Japan]
Lin T.,
Chao C.,
Saito S.,
Mazur S.J.,
Murphy M.E.,
Appella E.,
Xu Y.;
"p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression.";
Nat. Cell Biol. 7:165-171(2005).
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[11]
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INDUCTION.
DOI=10.1096/fj.05-5543fje; PubMed=16790525 [NCBI, ExPASy, EBI, Israel, Japan]
Pan G.,
Li J.,
Zhou Y.,
Zheng H.,
Pei D.;
"A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal.";
FASEB J. 20:1730-1732(2006).
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[12]
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INTERACTION WITH SALL4, AND DNA-BINDING.
DOI=10.1074/jbc.C600122200; PubMed=16840789 [NCBI, ExPASy, EBI, Israel, Japan]
Wu Q.,
Chen X.,
Zhang J.,
Loh Y.-H.,
Low T.-Y.,
Zhang W.,
Zhang W.,
Sze S.-K.,
Lim B.,
Ng H.-H.;
"Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells.";
J. Biol. Chem. 281:24090-24094(2006).
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[13]
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FUNCTION.
DOI=10.1038/nature04914; PubMed=16791199 [NCBI, ExPASy, EBI, Israel, Japan]
Silva J.,
Chambers I.,
Pollard S.,
Smith A.;
"Nanog promotes transfer of pluripotency after cell fusion.";
Nature 441:997-1001(2006).
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[14]
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FUNCTION, AND INDUCTION.
DOI=10.1038/ng1760; PubMed=16518401 [NCBI, ExPASy, EBI, Israel, Japan]
Loh Y.-H.,
Wu Q.,
Chew J.-L.,
Vega V.B.,
Zhang W.,
Chen X.,
Bourque G.,
George J.,
Leong B.,
Liu J.,
Wong K.-Y.,
Sung K.W.,
Lee C.W.,
Zhao X.-D.,
Chiu K.-P.,
Lipovich L.,
Kuznetsov V.A.,
Robson P.,
Stanton L.W., ![]()
Wei C.-L.,
Ruan Y.,
Lim B.,
Ng H.-H.;
"The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells.";
Nat. Genet. 38:431-440(2006).
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[15]
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FUNCTION, INTERACTION WITH SMAD1, AND INDUCTION.
DOI=10.1073/pnas.0506945103; PubMed=16801560 [NCBI, ExPASy, EBI, Israel, Japan]
Suzuki A.,
Raya A.,
Kawakami Y.,
Morita M.,
Matsui T.,
Nakashima K.,
Gage F.H.,
Rodriguez-Esteban C.,
Izpisua Belmonte J.C.;
"Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells.";
Proc. Natl. Acad. Sci. U.S.A. 103:10294-10299(2006).
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[16]
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X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 96-155, INTERACTION WITH DNA, PARTIAL PROTEIN SEQUENCE, AND MUTAGENESIS OF LYS-112; MET-126; TYR-137; LYS-138; THR-142; ASN-146 AND GLN-147.
DOI=10.1016/j.jmb.2007.11.091; PubMed=18177668 [NCBI, ExPASy, EBI, Israel, Japan]
Jauch R.,
Ng C.K.L.,
Saikatendu K.S.,
Stevens R.C.,
Kolatkar P.R.;
"Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog.";
J. Mol. Biol. 376:758-770(2008).
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