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UniProtKB/TrEMBL entry Q80Y89

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name Q80Y89_MOUSE
Primary accession number Q80Y89
Secondary accession numbers None
Integrated into TrEMBL on June 1, 2003
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    March 3, 2009 (Entry version 39)
Name and origin of the protein
Protein name Erbb2 protein
Synonyms None
Gene name
Name: Erbb2
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6;
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC046811; AAH46811.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC053078; AAH53078.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00626433; -.
UniGene Mm.290822
3D structure databases
HSSP P06494; 1N8Y. [HSSP ENTRY / PDB]
SMR Q80Y89; 23-630.
ModBase Q80Y89.
Organism-specific databases
MGI MGI:95410; Erbb2.
Gene expression databases
ArrayExpress Q80Y89; -.
Bgee Q80Y89; -.
Ontologies
GO
GO:0016324; Cellular component: apical plasma membrane (inferred from direct assay from MGI).
GO:0016323; Cellular component: basolateral plasma membrane (inferred from electronic annotation from Compara).
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from MGI).
GO:0043235; Cellular component: receptor complex (inferred from electronic annotation from Compara).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0019838; Molecular function: growth factor binding (inferred from electronic annotation from Compara).
GO:0042802; Molecular function: identical protein binding (inferred from electronic annotation from Compara).
GO:0046982; Molecular function: protein heterodimerization activity (inferred from electronic annotation from Compara).
GO:0004714; Molecular function: transmembrane receptor protein tyrosine kinase activity (inferred from electronic annotation from InterPro).
GO:0007507; Biological process: heart development (inferred from mutant phenotype from MGI).
GO:0008045; Biological process: motor axon guidance (inferred from mutant phenotype from MGI).
GO:0042552; Biological process: myelination (inferred from mutant phenotype from MGI).
GO:0033088; Biological process: negative regulation of immature T cell proliferation in the thymus (inferred from mutant phenotype from MGI).
GO:0007528; Biological process: neuromuscular junction development (inferred from mutant phenotype from MGI).
GO:0007422; Biological process: peripheral nervous system development (inferred from mutant phenotype from MGI).
GO:0014065; Biological process: phosphoinositide 3-kinase cascade (inferred from electronic annotation from Compara).
GO:0045785; Biological process: positive regulation of cell adhesion (inferred from electronic annotation from Compara).
GO:0050679; Biological process: positive regulation of epithelial cell proliferation (inferred from electronic annotation from Compara).
GO:0043406; Biological process: positive regulation of MAP kinase activity (inferred from electronic annotation from Compara).
GO:0046777; Biological process: protein amino acid autophosphorylation (inferred from electronic annotation from Compara).
GO:0007169; Biological process: transmembrane receptor protein tyrosine kinase signaling pathway (inferred from electronic annotation from InterPro).
GO:0042060; Biological process: wound healing (inferred from electronic annotation from Compara).
QuickGo view.
Family and domain databases
InterPro IPR000494; EGF_rcpt_L.
IPR006211; Furin-like.
IPR006212; Furin_repeat.
Graphical view of domain structure.
Pfam PF00757; Furin-like; 1.
PF01030; Recep_L_domain; 2.
Pfam graphical view of domain structure.
SMART SM00261; FU; 4.
SMART graphical view of domain structure.
Genome annotation databases
Ensembl ENSMUSG00000062312; Mus musculus. [Contig view]
Phylogenomic databases
HOVERGEN Q80Y89; -.
Other
SOURCE Erbb2; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
None
Features
None
Sequence information
Length: 711 AA Molecular weight: 78707 Da CRC64: 682B188EB0E71318 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MELAAWCRWG FLLALLSPGA AGTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL 

        70         80         90        100        110        120 
ELTYLPANAS LSFLQDIQEV QGYMLIAHNR VKHVPLQRLR IVRGTQLFED KYALAVLDNR 

       130        140        150        160        170        180 
DPLDNVTTAA PGRTPEGLRE LQLRSLTEIL KGGVLIRGNP QLCYQDMVLW KDVLRKNNQL 

       190        200        210        220        230        240 
APVDMDTNRS RACPPCAPTC KDNHCWGESP EDCQILTGTI CTSGCARCKG RLPTDCCHEQ 

       250        260        270        280        290        300 
CAAGCTGPKH SDCLACLHFN HSGICELHCP ALITYNTDTF ESMLNPEGRY TFGASCVTTC 

       310        320        330        340        350        360 
PYNYLSTEVG SCTLVCPPNN QEVTAEDGTQ RCEKCSKPCA GVCYGLGMEH LRGARAITSD 

       370        380        390        400        410        420 
NIQEFAGCKK IFGSLAFLPE SFDGNPSSGV APLKPEHLQV FETLEEITGY LYISAWPESF 

       430        440        450        460        470        480 
QDLSVFQNLR VIRGRILHDG AYSLTLQGLG IHSLGLRSLR ELGSGLALIH RNTHLCFVNT 

       490        500        510        520        530        540 
VPWDQLFRNP HQALLHSGNR PEEACGLEGL VCNSLCARGH CWGPGPTQCV NCSQFLRGQE 

       550        560        570        580        590        600 
CVEECRVWKG LPREYVRGKH CLPCHPECQP QNSSETCYGS EADQCEACAH YKDSSSCVAR 

       610        620        630        640        650        660 
CPSGVKPDLS YMPIWKYPDE EGICQPCPIN CTHSCVDLDE RGCPAEQRAS PVTFIIATVV 

       670        680        690        700        710 
GVLLFLIIVV VIGILIKRRR QKIRKYTMRR LLQETEVRRA EGLLAPPWLC S
Q80Y89 in FASTA format

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