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UniProtKB/Swiss-Prot entry Q7ZX15

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AKT2A_XENLA
Primary accession number Q7ZX15
Secondary accession numbers None
Integrated into Swiss-Prot on February 21, 2006
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 43)
Name and origin of the protein
Protein name RAC-beta serine/threonine-protein kinase A
Synonyms EC 2.7.11.1
RAC-PK-beta-A
Protein kinase Akt-2-A
Protein kinase B, beta-A
PKB beta-A
Gene name
Name: akt2-A
From
Xenopus laevis (African clawed frog) [TaxID: 8355] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC046261; AAH46261.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001080091.1; -.
UniGene Xl.5248
3D structure databases
HSSP P31751; 1MRY. [HSSP ENTRY / PDB]
SMR Q7ZX15; 1-113.
ModBase Q7ZX15.
Family and domain databases
InterPro IPR015744; Akt.
IPR001849; PH.
IPR011993; PH_type.
IPR000961; Pkinase_C.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR002290; Ser_thr_pkinase.
Graphical view of domain structure.
Gene3D G3DSA:2.30.29.30; PH_type; 1.
PANTHER PTHR22985:SF69; Akt; 1.
Pfam PF00169; PH; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
Pfam graphical view of domain structure.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
SMART graphical view of domain structure.
PROSITE PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q7ZX15.
Genome annotation databases
GeneID 379783; -.
KEGG xla:379783; -.
Phylogenomic databases
HOVERGEN Q7ZX15; -.
Other
ProtoNet Q7ZX15.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein; Serine/threonine-protein kinase; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   486  486     RAC-beta serine/threonine-protein kinase A. PRO_0000223508
DOMAIN   5   110  106     PH. 
DOMAIN   157   414  258     Protein kinase. 
DOMAIN   415   486  72     AGC-kinase C-terminal. 
NP_BIND   163   171  9     ATP (By similarity). 
ACT_SITE   280   280        Proton acceptor (By similarity). 
BINDING   186   186        ATP (By similarity). 
MOD_RES   314   314        Phosphothreonine (By similarity). 
MOD_RES   479   479        Phosphoserine (By similarity). 
Sequence information
Length: 486 AA [This is the length of the unprocessed precursor] Molecular weight: 56310 Da [This is the MW of the unprocessed precursor] CRC64: F124CAE30758016B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNEVMVIKEG WLQKRGEYIK TWRPRYFLLK SDGSFIGYKE KPESTEHNVV LPPLNNFSVA 

        70         80         90        100        110        120 
ECQLMKTERP RPNTFVIRCL QWTTVIERTF HVDTPEEREE WIIAIQTVAN GLKNQVPEDE 

       130        140        150        160        170        180 
EEEAMEVKYG SPSDVSSAEQ MDVAMSKGHP KVTMNDFDYL KLLGKGTFGK VILVREKATG 

       190        200        210        220        230        240 
RYYAMKILRK EVIIAKDEVA HTLTESRVLQ NTKHPFLTAL KYAFQTSDRL CFVMEYANGG 

       250        260        270        280        290        300 
ELFFHLSRER VFTEDRARFY GAEIVSALEY LHSRNVVYRD IKLENLMLDK DGHVKITDFG 

       310        320        330        340        350        360 
LCKEGITDGA TMRTFCGTPE YLAPEVLEDN DYGRAVDWWG LGVVMYEMMC GRLPFYNQDH 

       370        380        390        400        410        420 
ERLFELILME EIRFPRTLSP EAKSLLAGLL KKDPKQRLGG GPNDAQEVMS HRFFVSINWQ 

       430        440        450        460        470        480 
DVTERKLTPP FKPQVTSEID TRYFDDEFTA QSITLTPPDR YDNLDALESD QRPHFPQFSY 


SASIRE
Q7ZX15 in FASTA format

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