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UniProtKB/Swiss-Prot entry Q7Z6W7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DNJB7_HUMAN
Primary accession number Q7Z6W7
Secondary accession numbers Q2M220 Q5H904 Q8WYJ7
Integrated into Swiss-Prot on March 1, 2004
Sequence was last modified on March 1, 2004 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 45)
Name and origin of the protein
Protein name DnaJ homolog subfamily B member 7
Synonyms None
Gene name
Name: DNAJB7
Synonyms: HSC3
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Xing Y., Yu L., Fu Q., Zhao Y., Bi A., Zhao S.;
"Cloning a novel human gene, HSC3, which shows significant homology to murine MRJ.";
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1186/gb-2004-5-10-r84; PubMed=15461802 [NCBI, ExPASy, EBI, Israel, Japan]
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.;
"A genome annotation-driven approach to cloning the human ORFeome.";
Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/990031; PubMed=10591208 [NCBI, ExPASy, EBI, Israel, Japan]
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.;
"The DNA sequence of human chromosome 22.";
Nature 402:489-495(1999).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF085232; AAL40391.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR456468; CAG30354.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z98048; CAI20493.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC112135; AAI12136.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00103726; -.
RefSeq NP_660157.1; -.
UniGene Hs.585042
3D structure databases
SMR Q7Z6W7; 1-71.
ModBase Q7Z6W7.
PTM databases
PhosphoSite Q7Z6W7; -.
Organism-specific databases
GeneCards GC22M039581; -.
HGNC HGNC:24986; DNAJB7.
GenAtlas DNAJB7.
HPA HPA000534; -.
MIM 611336; gene. [NCBI / EBI]
PharmGKB PA134961522; -.
Gene expression databases
ArrayExpress Q7Z6W7; -.
Bgee Q7Z6W7; -.
CleanEx HS_DNAJB7; -.
GermOnline ENSG00000172404; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from HPA).
GO:0005634; Cellular component: nucleus (inferred from direct assay from HPA).
GO:0031072; Molecular function: heat shock protein binding (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001623; DnaJ_N.
IPR018253; Heat_shock_DnaJ_CS.
IPR015609; Hsp40/DnaJ_Rel.
Graphical view of domain structure.
Gene3D G3DSA:1.10.287.110; DnaJ_N; 1.
PANTHER PTHR11821; Hsp40/DnaJ_Rel; 1.
Pfam PF00226; DnaJ; 1.
Pfam graphical view of domain structure.
SMART SM00271; DnaJ; 1.
SMART graphical view of domain structure.
PROSITE PS00636; DNAJ_1; 1.
PS50076; DNAJ_2; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q7Z6W7; -.
Genome annotation databases
Ensembl ENSG00000172404; Homo sapiens. [Contig view]
GeneID 150353; -.
KEGG hsa:150353; -.
Phylogenomic databases
HOGENOM Q7Z6W7; -.
HOVERGEN Q7Z6W7; -.
OMA Q7Z6W7; VALKWHP.
Other
NextBio 86410; -.
SOURCE DNAJB7; Homo sapiens.
ProtoNet Q7Z6W7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Chaperone; Polymorphism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   309  309     DnaJ homolog subfamily B member 7. PRO_0000071027
DOMAIN   3    69  67     J. 
COMPBIAS   291   298  8     Poly-Lys. 
VARIANT   41    41  1     E -> A (in dbSNP:rs2269619 [NCBI]). VAR_017779 
Sequence information
Length: 309 AA [This is the length of the unprocessed precursor] Molecular weight: 35434 Da [This is the MW of the unprocessed precursor] CRC64: 64F0F8544CDB8984 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVDYYEVLGL QRYASPEDIK KAYHKVALKW HPDKNPENKE EAERKFKEVA EAYEVLSNDE 

        70         80         90        100        110        120 
KRDIYDKYGT EGLNGGGSHF DDECEYGFTF HKPDDVFKEI FHERDPFSFH FFEDSLEDLL 

       130        140        150        160        170        180 
NRPGSSYGNR NRDAGYFFST ASEYPIFEKF SSYDTGYTSQ GSLGHEGLTS FSSLAFDNSG 

       190        200        210        220        230        240 
MDNYISVTTS DKIVNGRNIN TKKIIESDQE REAEDNGELT FFLVNSVANE EGFAKECSWR 

       250        260        270        280        290        300 
TQSFNNYSPN SHSSKHVSQY TFVDNDEGGI SWVTSNRDPP IFSAGVKEGG KRKKKKRKEV 


QKKSTKRNC 

Q7Z6W7 in FASTA format

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