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UniProtKB/Swiss-Prot entry Q7Z401


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MYCPP_HUMAN
Primary accession number Q7Z401
Secondary accession numbers Q14655 Q86T77 Q8IVX2 Q8NB93
Integrated into Swiss-Prot on February 21, 2006
Sequence was last modified on February 21, 2006 (Sequence version 2)
Annotations were last modified on    September 23, 2008 (Entry version 40)
Name and origin of the protein
Protein name C-myc promoter-binding protein
Synonym DENN domain-containing protein 4A
Gene name
Name: DENND4A
Synonyms: IRLB, MYCPBP
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
DOI=10.1016/S0888-7543(03)00103-4; PubMed=12906859 [NCBI, ExPASy, EBI, Israel, Japan]
Semova N., Kapanadze B., Corcoran M., Kutsenko A., Baranova A., Semov A.;
"Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges.";
Genomics 82:343-354(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-284.
TISSUE=Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-928.
TISSUE=Brain;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-1863.
TISSUE=Spinal cord;
The German cDNA consortium;
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 1673-1863, AND FUNCTION.
DOI=10.1016/0378-1119(94)90018-3; PubMed=8056341 [NCBI, ExPASy, EBI, Israel, Japan]
Stasiv Y.Z., Mashkova T.D., Chernov B.K., Sokolava I.V., Itkes A.V., Kisselev L.L.;
"Cloning of a cDNA encoding a human protein which binds a sequence in the c-myc gene similar to the interferon-stimulated response element.";
Gene 145:267-272(1994).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1281 AND SER-1511, AND MASS SPECTROMETRY.
DOI=10.1021/pr0705441; PubMed=18220336 [NCBI, ExPASy, EBI, Israel, Japan]
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF534403; AAQ10514.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC041706; AAH41706.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK091368; BAC03648.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL832602; CAD89960.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X63417; CAA45013.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I37904; I37904.
RefSeq NP_005839.2; -.
UniGene Hs.654567
3D structure databases
ModBase Q7Z401.
Protein-protein interaction databases
IntAct Q7Z401; -.
Organism-specific databases
H-InvDB HIX0001093; -.
HIX0012356; -.
HGNC HGNC:24321; DENND4A.
GenAtlas DENND4A.
MIM 600382; gene. [NCBI / EBI]
GeneCards Q7Z401.
Gene expression databases
ArrayExpress Q7Z401; -.
CleanEx HS_DENND4A; -.
GermOnline ENSG00000174485; Homo sapiens.
Ontologies
GO
GO:0005634; Cellular component: nucleus (non-traceable author statement from UniProtKB).
GO:0003677; Molecular function: DNA binding (non-traceable author statement from UniProtKB).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR005112; dDENN.
IPR001194; DENN.
IPR002885; PPR.
IPR005113; uDENN.
Graphical view of domain structure.
Pfam PF03455; dDENN; 1.
PF02141; DENN; 1.
PF01535; PPR; 1.
PF03456; uDENN; 1.
Pfam graphical view of domain structure.
SMART SM00801; dDENN; 1.
SM00799; DENN; 1.
SM00800; uDENN; 1.
SMART graphical view of domain structure.
TIGRFAMs TIGR00756; PPR; 1.
PROSITE PS50947; DDENN; 1.
PS50211; DENN; 1.
PS51375; PPR; 1.
PS50946; UDENN; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q7Z401.
Genome annotation databases
Ensembl ENSG00000174485; Homo sapiens. [Contig view]
GeneID 10260; -.
KEGG hsa:10260; -.
Phylogenomic databases
HOGENOM Q7Z401; -.
HOVERGEN Q7Z401; -.
Other
SOURCE DENND4A; Homo sapiens.
ProtoNet Q7Z401.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Repeat; Transcription; Transcription regulation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1863  1863     C-myc promoter-binding protein. PRO_0000223952
DOMAIN   6    282  277     uDENN. 
DOMAIN   308    492  185     DENN. 
DOMAIN   558    632  75     dDENN. 
REPEAT   772    808  37     PPR 1. 
REPEAT   809    843  35     PPR 2. 
MOTIF   917    933  17     Bipartite nuclear localization signal (Potential). 
COMPBIAS   1183   1189  7     Poly-Glu. 
MOD_RES   1281   1281        Phosphoserine. 
MOD_RES   1511   1511        Phosphoserine. 
VARIANT   284    284  1     L -> P (in dbSNP:rs17854146 [NCBI]). VAR_025362 
CONFLICT   383    383        S -> P (in Ref. 4; CAD89960). 
CONFLICT   983    983        M -> MGK (in Ref. 1; AAQ10514). 
Sequence information
Length: 1863 AA [This is the length of the unprocessed precursor] Molecular weight: 209244 Da [This is the MW of the unprocessed precursor] CRC64: 7432EEC9DB9711E6 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MIEDKGPRVA DYFVVAGLTD VSKPLEEEIH FNDACHKVAK PKEPITDVSV IIKSLGEEVP 

        70         80         90        100        110        120 
QDYICIDVTP TGLSADLNNG SLVGPQIYLC YRRGRDKPPL TDLGVLYDWK ERLKQGCEII 

       130        140        150        160        170        180 
QSTPYGRPAN ISGSTSSQRI YITYRRASEN MTQNTLAVTD ICIIIPSKGE SPPHTFCKVD 

       190        200        210        220        230        240 
KNLNNSMWGS AVYLCYKKSV AKTNTVSYKA GLICRYPQED YESFSLPESV PLFCLPMGAT 

       250        260        270        280        290        300 
IECWPSNSKY PLPVFSTFVL TGASAEKVYG AAIQFYEPYS EENLTEKQRL LLGLTSADGK 

       310        320        330        340        350        360 
SDSSKTIHTN KCICLLSHWP FFDAFRKFLT FLYRYSISGP HVLPIEKHIS HFMHKVPFPS 

       370        380        390        400        410        420 
PQRPRILVQL SPHDNLILSQ PVSSPLPLSG GKFSTLLQNL GPENAVTLLV FAVTEHKILI 

       430        440        450        460        470        480 
HSLRPSVLTS VTEALVSMIF PFHWPCPYVP LCPLALADVL SAPCPFIVGI DSRYFDLYDP 

       490        500        510        520        530        540 
PPDVSCVDVD TNTISQIGDK KNVAWKILPK KPCKNLMNTL NNLHQQLAKL QQRPRDDGLM 

       550        560        570        580        590        600 
DLAINDYDFN SGKRLHMIDL EIQEAFLFFM ASILKGYRSY LRPITQAPSE TATDAASLFA 

       610        620        630        640        650        660 
LQAFLRSRDR SHQKFYNMMT KTQMFIRFIE ECSFVSDKDA SLAFFDDCVD KVDMDKSGEV 

       670        680        690        700        710        720 
RLIELDESFK SEHTVFVTPP EIPHLPNGEE PPLQYSYNGF PVLRNNLFER PEGFLQAKKN 

       730        740        750        760        770        780 
KLPSKSSSPN SPLPMFRRTK QEIKSAHKIA KRYSSIPQMW SRCLLRHCYG LWFICLPAYV 

       790        800        810        820        830        840 
KVCHSKVRAL KTAYDVLKKM QSKKMDPPDE VCYRILMQLC GQYDQPVLAV RVLFEMQKAG 

       850        860        870        880        890        900 
IDPNAITYGY YNKAVLESTW PSRSRSGYFL WTKVRNVVLG VTQFKRALKK HAHLSQTTLS 

       910        920        930        940        950        960 
GGQSDLGYNS LSKDEVRRGD TSTEDIQEEK DKKGSDCSSL SESESTKGSA DCLPKLSYQN 

       970        980        990       1000       1010       1020 
SSSIVRLTGT SNNSAGKISG ESMESTPELL LISSLEDTNE TRNIQSRCFR KRHKSDNETN 

      1030       1040       1050       1060       1070       1080 
LQQQVVWGNR NRNLSGGVLM GFMLNRINQE ATPGDIVEKL GADAKILSNV ISKSTRPNTL 

      1090       1100       1110       1120       1130       1140 
DIGKPPLRSK RDSLEKESSD DDTPFDGSNY LADKVDSPVI FDLEDLDSET DVSKAGCVAT 

      1150       1160       1170       1180       1190       1200 
QNPKRIQRMN SSFSVKPFEK TDVATGFDPL SLLVAETEQQ QKEEEEEDED DSKSISTPSA 

      1210       1220       1230       1240       1250       1260 
RRDLAEEIVM YMNNMSSPLT SRTPSIDLQR ACDDKLNKKS PPLVKACRRS SLPPNSPKPV 

      1270       1280       1290       1300       1310       1320 
RLTKSKSYTK SEEKPRDRLW SSPAFSPTCP FREESQDTLT HSSPSFNLDT LLVPKLDVLR 

      1330       1340       1350       1360       1370       1380 
NSMFTAGKGV AEKASKWYSR FTMYTTSSKD QSSDRTSLSS VGAQDSESTS LTDEDVCHEL 

      1390       1400       1410       1420       1430       1440 
EGPISSQETS ATSGTKRIDL SRISLESSAS LEGSLSKFAL PGKSEVTSSF NASNTNIFQN 

      1450       1460       1470       1480       1490       1500 
YAMEVLISSC SRCRTCDCLV HDEEIMAGWT ADDSNLNTTC PFCGNIFLPF LNIEIRDLRR 

      1510       1520       1530       1540       1550       1560 
PGRYFLKSSP STENMHFPSS ISSQTRQSCI STSASGLDTS ALSVQGNFDL NSKSKLQENF 

      1570       1580       1590       1600       1610       1620 
CTRSIQIPAN RSKTAMSKCP IFPMARSIST SGPLDKEDTG RQKLISTGSL PATLQGATDS 

      1630       1640       1650       1660       1670       1680 
LGLEWHLPSP DPVTVPYLSP LVVWKELESL LENEGDHAIT VADFVDHHPI VFWNLVWYFR 

      1690       1700       1710       1720       1730       1740 
RLDLPSNLPG LILSSEHCNK YSKIPRHCMS EDSKYVLIQM LWDNMKLHQD PGQPLYILWN 

      1750       1760       1770       1780       1790       1800 
AHTQKYPMVH LLQKSDNSFN QELLKSMVKS IKMNDVYGPM SQILETLNKC PHFKRQRSLY 

      1810       1820       1830       1840       1850       1860 
REILFLSLVA LGRENIDIDA FDKEYKMAYD RLTPSQVKST HNCDRPPSTG VMECRKTFGE 


PYL 

Q7Z401 in FASTA format

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