NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Endometrium;
DOI=10.1095/biolreprod.103.020719; PubMed=14561654 [NCBI, ExPASy, EBI, Israel, Japan]
Melner M.H., Ducharme N.A., Brash A.R., Winfrey V.P., Olson G.E.;
"Differential expression of genes in the endometrium at implantation: upregulation of a novel member of the E2 class of ubiquitin-conjugating enzymes.";
Biol. Reprod. 70:406-414(2004).

Comments

FUNCTION: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity).
CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
PATHWAY: Protein modification; protein ubiquitination .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Detected at embryo implantation sites in the luminal epithelium of pregnant endometrium. Detected at low levels in ovary and liver.
INDUCTION: Up-regulated in pregnant endometrium during implantation.
SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY330351; AAP93920.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001076163.1; -.

UniGene

Ocu.3117

3D structure databases

SMR

Q7YQJ9; 195-356.

ModBase

Q7YQJ9.

Family and domain databases

InterPro

IPR016135; UBQ-conjugat/RWD-like.
IPR000608; UBQ-conjugat_E2.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.110.10; UBQ-conjugat_E2; 1.

PANTHER

PTHR11621; UBQ-conjugat_E2; 1.

Pfam

PF00179; UQ_con; 1.
Pfam graphical view of domain structure.

ProDom

PD000461; UBQ_conjugat; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00212; UBCc; 1.
SMART graphical view of domain structure.

PROSITE

PS00183; UBIQUITIN_CONJUGAT_1; FALSE_NEG.
PS50127; UBIQUITIN_CONJUGAT_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q7YQJ9.

Genome annotation databases

GeneID

100009425; -.

Phylogenomic databases

HOVERGEN

Q7YQJ9; -.

Other

ProtoNet

Q7YQJ9.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Cytoplasm; Ligase; Nucleotide-binding; Ubl conjugation pathway.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 369`	`369`	`Ubiquitin-conjugating enzyme E2 Q2.`	`PRO_0000223881`
`COMPBIAS`	`129 172`	`44`	`Glu-rich.`
`ACT_SITE`	`298 298`		`Glycyl thioester intermediate (By similarity).`

Sequence information

Length: 369 AA [This is the length of the unprocessed precursor]

Molecular weight: 42192 Da [This is the MW of the unprocessed precursor]

CRC64: 3B88532499960CF3 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPAPPLLTL HCNITESYPS 

        70         80         90        100        110        120 
SSPIWFVDSD DPNLTSVLER LEDSKNNNSL RQQLKWLICE LCRLYNLPKH LDVEMLDQPL 

       130        140        150        160        170        180 
PTGQNGTTEE VTSEEEEEEE MAEDIEDLDH YEMKEEEPIN GRKSEDEGIE KENLAILEKI 

       190        200        210        220        230        240 
RKSQRQDHLN GAVSGSVQAS DRLMKELRDI YRSQSYKTGI YSVELINDSL YDWHVKLQKV 

       250        260        270        280        290        300 
DPDSPLHSDL QILKEKEGIE YILLNFSFKD NFPFDPPFVR VVLPVLSGGY VLGGGALCME 

       310        320        330        340        350        360 
LLTKQGWSSA YSIESVIMQI NATLVKGKAR VQFGANKNQY NLARAQQSYN SIVQIHEKNG 


WYTPPKEDG

Q7YQJ9 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools