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UniProtKB/Swiss-Prot entry Q7WNM3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LEU31_BORBR
Primary accession number Q7WNM3
Secondary accession numbers None
Integrated into Swiss-Prot on September 19, 2006
Sequence was last modified on October 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 35)
Name and origin of the protein
Protein name 3-isopropylmalate dehydrogenase 1
Synonyms EC 1.1.1.85
Beta-IPM dehydrogenase 1
IMDH 1
3-IPM-DH 1
Gene name
Name: leuB1
OrderedLocusNames: BB1014
From
Bordetella bronchiseptica (Alcaligenes bronchisepticus) [TaxID: 518] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Bordetella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=RB50 / ATCC BAA-588 / NCTC 13252;
DOI=10.1038/ng1227; PubMed=12910271 [NCBI, ExPASy, EBI, Israel, Japan]
Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.;
"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.";
Nat. Genet. 35:32-40(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX640440; CAE31513.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_887562.1; -.
3D structure databases
HSSP Q56268; 1A05. [HSSP ENTRY / PDB]
ModBase Q7WNM3.
Enzyme and pathway databases
BioCyc BBRO257310:BB1014-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003862; Molecular function: 3-isopropylmalate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009098; Biological process: leucine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01033; -; 1.
PBIL [Tree]
InterPro IPR004429; 3-isopropylmalate_DHase.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF13; IPMDH; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00169; leuB; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q7WNM3.
Genome annotation databases
GeneID 2663175; -.
GenomeReviews BX470250_GR; BB1014.
KEGG bbr:BB1014; -.
NMPDR fig|257310.1.peg.1009; -.
Phylogenomic databases
HOGENOM Q7WNM3; -.
Genome annotation databases
CMR Q7WNM3; BB1014.
Other
ProtoNet Q7WNM3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   370  370     3-isopropylmalate dehydrogenase 1. PRO_0000250103
NP_BIND   289   301  13     NAD (By similarity). 
METAL   227   227        Magnesium or manganese (By similarity). 
METAL   251   251        Magnesium or manganese (By similarity). 
METAL   255   255        Magnesium or manganese (By similarity). 
BINDING   98    98        Substrate (By similarity). 
BINDING   108   108        Substrate (By similarity). 
BINDING   136   136        Substrate (By similarity). 
BINDING   227   227        Substrate (By similarity). 
SITE   143   143  1     Important for catalysis (By similarity). 
SITE   194   194  1     Important for catalysis (By similarity). 
Sequence information
Length: 370 AA [This is the length of the unprocessed precursor] Molecular weight: 39907 Da [This is the MW of the unprocessed precursor] CRC64: E58A5488FBF1034F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSEQNRLLLI GGDGVGAEVV HEAGRIAQWF AARRGLPLSI GQAAFGVEVL NRTGRIMTDD 

        70         80         90        100        110        120 
TLAQIRAADA VLFGAIGGPE YDRLPLEQVR EEGLLRIRRE LGLYANLRPV RYWPALAELC 

       130        140        150        160        170        180 
PFVPERVEKV DMMIVRELAG GIYYASPRGI DQTGDGRRVG TNTQRYDDLE IRRIARVAFE 

       190        200        210        220        230        240 
LARARGGRVC SVDKSNVLES GLLWREEVQA CRDAEYPDVE LEHILVDNCA LQLCLRPARF 

       250        260        270        280        290        300 
DVLLADNLFG DILSDAAGAV AGSLGMLPSA SFGAEDGGRR RGFYEPVHGS APDIAGQGIA 

       310        320        330        340        350        360 
NPLGAILSLA LALRWTFRQP AEADLLERAV ERALAGGART LDLLAGAAAP ALSTRAMADA 

       370 
VLQALETLAA
Q7WNM3 in FASTA format

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