NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=301 / Serotype 2a;
DOI=10.1093/nar/gkf566; PubMed=12384590 [NCBI, ExPASy, EBI, Israel, Japan]
Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157.";
Nucleic Acids Res. 30:4432-4441(2002).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700930 / 2457T / Serotype 2a;
DOI=10.1128/IAI.71.5.2775-2786.2003; PubMed=12704152 [NCBI, ExPASy, EBI, Israel, Japan]
Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
"Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T.";
Infect. Immun. 71:2775-2786(2003).

Comments

FUNCTION: Adenylation and deadenylation of glutamine synthetase (By similarity).
CATALYTIC ACTIVITY: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)].
SIMILARITY: Belongs to the glnE family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE005674; AAN44570.1; ALT_INIT; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014073; AAP18382.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_708863.2; -.
NP_838572.1; -.

3D structure databases

ModBase

Q7UBI7.

Enzyme and pathway databases

BioCyc

SFLE198214:AAN44570.1-MON; -.

Ontologies

GO:0008882;	Molecular function: [glutamate-ammonia-ligase] adenylyltransferase activity (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00802; -; 1.
PBIL [Tree]

InterPro

IPR005190; GlnE.
Graphical view of domain structure.

Pfam

PF03710; GlnE; 2.
Pfam graphical view of domain structure.

Genome annotation databases

GeneID

1026840; -.
1079543; -.

GenomeReviews

AE014073_GR; S3299.
AE005674_GR; SF3094.

KEGG

sfl:SF3094; -.
sfx:S3299; -.

Phylogenomic databases

HOGENOM

Q7UBI7; -.

Genome annotation databases

CMR

Q7UBI7; SF3094.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Nucleotidyltransferase; Repeat; Transferase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 946`	`946`	`Glutamate-ammonia-ligase adenylyltransferase.`	`PRO_0000209278`
`REGION`	`91 302`	`212`	`GlnE 1.`
`REGION`	`609 830`	`222`	`GlnE 2.`

Sequence information

Length: 946 AA [This is the length of the unprocessed precursor]

Molecular weight: 108391 Da [This is the MW of the unprocessed precursor]

CRC64: 0E3030A2FA5466D9 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKPLSSPLQQ YWQTVVERLP ELLAEESLSA QAKSVLTFSD FVQDSVIAHP EWLTELESQP 

        70         80         90        100        110        120 
PQADEWQHYS VWLQEALSNV SDEAGLMREL RLFRRRIMVR IAWAQTLALV TEESILQQLS 

       130        140        150        160        170        180 
YLAETLIVAA RDWLYDACCR EWGTPCNAQG EAQPLLILGM GKLGGGELNF SSDIDLIFAW 

       190        200        210        220        230        240 
PEHGCTQGGR RELDNAQFFT RMGQRLIKVL DQPTQDGFVY RVDMRLRPFG ESGPLVLSFA 

       250        260        270        280        290        300 
ALEDYYQEQG RDWERYAMVK ARIMGDSEGV YANELRAMLR PFVFRRYIDF SVIQSLRNMK 

       310        320        330        340        350        360 
GMIAREVRRR GLTDNIKLGA GGIREIEFIV QVFQLIRGGR EPLLQSRSLL PTLSAIAALH 

       370        380        390        400        410        420 
LLSENDAEQL RVAYLFLRRL ENLLQSINDE QTQTLPSDEL NRARLAWAMD FADWPQLTGA 

       430        440        450        460        470        480 
LTAHMTNVRR VFNELIGDDE SETQEESLSE QWRELWQDAL QEDDTTPVLA HLSEDDRKQV 

       490        500        510        520        530        540 
LTMIADFRKE LDKRTIGPRG RQVLDHLMPH LLSDVCARED AAVTLSRITA LLVGIVTRTT 

       550        560        570        580        590        600 
YLELLSEFPA ALKHLISLCA ASPMIASQLA RYPLLLDELL DPNTLYQPTA TDAYRDELRQ 

       610        620        630        640        650        660 
YLLRVPEDDE EQQLEALRQF KQAQLLRIAA ADIAGTLPVM KVSDHLTWLA EAMIDAVVQQ 

       670        680        690        700        710        720 
AWGQMVARYG KPNHLNEREG RGFAVVGYGK LGGWELGYSS DLDLIFLHDC PMDAMTDGER 

       730        740        750        760        770        780 
EIDGRQFYLR LAQRIMHLFS TRTSSGILYE VDARLRPSGA AGMLVTSAEA FADYQKNEAW 

       790        800        810        820        830        840 
TWEHQALVRA RVVYGDPQLT AHFDAVRREI MTLPREGKTL QTEVREMREK MRAHLGNKHR 

       850        860        870        880        890        900 
NRFDIKADEG GITDIEFITQ YLVLRYAHEK PKLTRWSDNV RILELLAQND IMEEQEAMAL 

       910        920        930        940 
TRAYTTLRDE LHHLALQELP GHVSEDCFTA ERDLVRASWQ KWLVEE

Q7UBI7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools