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UniProtKB/Swiss-Prot entry Q7U635

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HIS2_SYNPX
Primary accession number Q7U635
Secondary accession numbers None
Integrated into Swiss-Prot on March 15, 2004
Sequence was last modified on October 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 32)
Name and origin of the protein
Protein name Histidine biosynthesis bifunctional protein hisIE
Synonyms None
Includes Phosphoribosyl-AMP cyclohydrolase
     (PRA-CH)
     (EC 3.5.4.19)
Phosphoribosyl-ATP pyrophosphatase
     (PRA-PH)
     (EC 3.6.1.31)
Gene name
Name: hisI
Synonyms: hisIE
OrderedLocusNames: SYNW1505
From
Synechococcus sp. (strain WH8102) [TaxID: 84588] [HAMAP proteome]
Taxonomy Bacteria; Cyanobacteria; Chroococcales; Synechococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature01943; PubMed=12917641 [NCBI, ExPASy, EBI, Israel, Japan]
Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J.;
"The genome of a motile marine Synechococcus.";
Nature 424:1037-1042(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX569693; CAE08020.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_897598.1; -.
3D structure databases
ModBase Q7U635.
Enzyme and pathway databases
BioCyc SSP84588:SYNW1505/OR0440-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004635; Molecular function: phosphoribosyl-AMP cyclohydrolase activity (inferred from electronic annotation from HAMAP).
GO:0004636; Molecular function: phosphoribosyl-ATP diphosphatase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01019; -; 1.
PBIL [Tree]
InterPro IPR002496; PRA_CycOHase.
IPR008179; PRib-ATP_pyrophosphohydrolase.
Graphical view of domain structure.
Pfam PF01502; PRA-CH; 1.
PF01503; PRA-PH; 1.
Pfam graphical view of domain structure.
ProDom PD002610; PRA_cyclohydro; 1.
PD002611; Pra_PH/CH; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR03188; histidine_hisI; 1.
BLOCKS Q7U635.
ProtoNet Q7U635.
Genome annotation databases
GeneID 1730396; -.
GenomeReviews BX548020_GR; SYNW1505.
KEGG syw:SYNW1505; -.
Phylogenomic databases
HOGENOM Q7U635; -.
Genome annotation databases
CMR Q7U635; SYNW1505.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Cytoplasm; Histidine biosynthesis; Hydrolase; Multifunctional enzyme.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   222  222     Histidine biosynthesis bifunctional protein hisIE. PRO_0000136439
REGION   1   128  128     Phosphoribosyl-AMP cyclohydrolase. 
REGION   129   222  94     Phosphoribosyl-ATP pyrophosphohydrolase. 
Sequence information
Length: 222 AA [This is the length of the unprocessed precursor] Molecular weight: 24704 Da [This is the MW of the unprocessed precursor] CRC64: 36F5CDFBCB2251F5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MQPLSPAFID QLRFNEAGLI PAIAQDWLDG AVLMVAWMNR ESIQQTLNSG EAHYWSRSRQ 

        70         80         90        100        110        120 
ELWHKGATSG HTQTLRSIRY DCDADVLLLT IEQRGDIACH TGARSCFYEG GDQRSDGGSN 

       130        140        150        160        170        180 
ALSPPADACT ELFRVIESRR DNPEEGSYTN KLLEGGDNKI LKKIGEESAE FVMACKDDNP 

       190        200        210        220 
EEIAGEAADI LFHMQVALAH HGVSWRQVQE VLAARRGAPR RH
Q7U635 in FASTA format

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