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UniProtKB/Swiss-Prot entry Q7U3W8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GSHB_SYNPX
Primary accession number Q7U3W8
Secondary accession numbers None
Integrated into Swiss-Prot on December 15, 2003
Sequence was last modified on October 1, 2003 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 31)
Name and origin of the protein
Protein name Glutathione synthetase
Synonyms EC 6.3.2.3
Glutathione synthase
GSH synthetase
GSH-S
GSHase
Gene name
Name: gshB
OrderedLocusNames: SYNW2309
From
Synechococcus sp. (strain WH8102) [TaxID: 84588] [HAMAP proteome]
Taxonomy Bacteria; Cyanobacteria; Chroococcales; Synechococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature01943; PubMed=12917641 [NCBI, ExPASy, EBI, Israel, Japan]
Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J.;
"The genome of a motile marine Synechococcus.";
Nature 424:1037-1042(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX569695; CAE08824.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_898398.1; -.
3D structure databases
ModBase Q7U3W8.
Enzyme and pathway databases
BioCyc SSP84588:SYNW2309/OR2553-MON; -.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0004363; Molecular function: glutathione synthase activity (inferred from electronic annotation from HAMAP).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030145; Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006750; Biological process: glutathione biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00162; -; 1.
PBIL [Tree]
InterPro IPR011761; ATP-grasp.
IPR013816; ATP_grasp_subdomain_2.
IPR006284; Glut_synth_pro.
IPR004218; GSHS_ATP_bd.
IPR004215; GSHS_N.
IPR013817; Pre-ATP_grasp.
Graphical view of domain structure.
Gene3D G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
G3DSA:3.40.50.20; Pre-ATP_grasp; 1.
Pfam PF02955; GSH-S_ATP; 1.
PF02951; GSH-S_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01380; glut_syn; 1.
PROSITE PS50975; ATP_GRASP; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q7U3W8.
ProtoNet Q7U3W8.
Genome annotation databases
GeneID 1730296; -.
GenomeReviews BX548020_GR; SYNW2309.
KEGG syw:SYNW2309; -.
Phylogenomic databases
HOGENOM Q7U3W8; -.
Genome annotation databases
CMR Q7U3W8; SYNW2309.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Glutathione biosynthesis; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   307  307     Glutathione synthetase. PRO_0000197489
DOMAIN   120   304  185     ATP-grasp. 
NP_BIND   146   202  57     ATP (By similarity). 
METAL   275   275        Magnesium or manganese (By similarity). 
METAL   277   277        Magnesium or manganese (By similarity). 
Sequence information
Length: 307 AA [This is the length of the unprocessed precursor] Molecular weight: 33471 Da [This is the MW of the unprocessed precursor] CRC64: B67978A17E6FFFB5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRQLFVLDPL SQIRPEKDST AALMQAAQRA GDDIWSCTPS DLIARGDEPM AVALPVTPDP 

        70         80         90        100        110        120 
WIAVGAPERQ SLAGFDVIWM RKDPPVDEAY LYATHLLEVA ERAGVRVLNR PSALRAWNEK 

       130        140        150        160        170        180 
LGALRFSRWM APTLVAGRVS ELMAFAREQG DVVLKPLGGR AGLGVIRVQA EAPGLKALLE 

       190        200        210        220        230        240 
LVTEQERLPV MAQRFLPDVT EGDKRILLVD GDPLGAVNRR PSEGEFRSNL AVGGQAEATE 

       250        260        270        280        290        300 
LSEPERQICA ALAPALRAEG LFFVGIDVIG GMLSEINVTS PTGVREVERL MQEPLADQTI 


ERLRSLV
Q7U3W8 in FASTA format

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