ID   DNAE2_MYCBO             Reviewed;        1091 AA.
AC   Q7TWL9;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 2.
DT   22-JUL-2008, entry version 34.
DE   RecName: Full=Error-prone DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=dnaE2; OrderedLocusNames=Mb3405c;
OS   Mycobacterium bovis.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1765;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   MEDLINE=22709107; PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H.,
RA   Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S.,
RA   Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R.,
RA   Parkhill J., Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis
CC       and translesion synthesis (TLS). It is not the major replicative
CC       DNA polymerase (By similarity).
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily.
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DR   EMBL; BX248345; CAD95567.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_857046.2; -.
DR   GeneID; 1090941; -.
DR   GenomeReviews; BX248333_GR; Mb3405c.
DR   KEGG; mbo:Mb3405c; -.
DR   HOGENOM; Q7TWL9; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:HAMAP.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:HAMAP.
DR   GO; GO:0045020; P:error-prone DNA repair; IEA:HAMAP.
DR   HAMAP; MF_01902; -; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha.
DR   InterPro; IPR004365; NA_bd_OB_tRNA-helicase.
DR   InterPro; IPR004013; PHP_C.
DR   InterPro; IPR003141; PHP_N.
DR   InterPro; IPR004805; PolC_alpha.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
FT   CHAIN         1   1091       Error-prone DNA polymerase.
FT                                /FTId=PRO_0000103383.
SQ   SEQUENCE   1091 AA;  117784 MW;  F4973A856D56711D CRC64;
     MGWSNGPPSW AEMERVLNGK PRHAGVPAFD ADGDVPRSRK RGAYQPPGRE RVGSSVAYAE
     LHAHSAYSFL DGASTPEELV EEAARLGLCA LALTDHDGLY GAVRFAEAAA ELDVRTVFGA
     ELSLGATART ERPDPPGPHL LVLARGPEGY RRLSRQLAAA HLAGGEKGKP RYDFDALTEA
     AGGHWHILTG CRKGHVRQAL SQGGPAAAQR ALADLVDRFT PSRVSIELTH HGHPLDDERN
     AALAGLAPRF GVGIVATTGA HFADPSRGRL AMAMAAIRAR RSLDSAAGWL APLGGAHLRS
     GEEMARLFAW CPEAVTAAAE LGERCAFGLQ LIAPRLPPFD VPDGHTEDSW LRSLVMAGAR
     ERYGPPKSAP RAYSQIEHEL KVIAQLRFPG YFLVVHDITR FCRDNDILCQ GRGSAANSAV
     CYALGVTAVD PVANELLFER FLSPARDGPP DIDIDIESDQ REKVIQYVYH KYGRDYAAQV
     ANVITYRGRS AVRDMARALG FSPGQQDAWS KQVSHWTGQA DDVDGIPEQV IDLATQIRNL
     PRHLGIHSGG MVICDRPIAD VCPVEWARMA NRSVLQWDKD DCAAIGLVKF DLLGLGMLSA
     LHYAKDLVAE HKGIEVDLAR LDLSEPAVYE MLARADSVGV FQVESRAQMA TLPRLKPRVF
     YDLVVEVALI RPGPIQGGSV HPYIRRRNGV DPVIYEHPSM APALRKTLGV PLFQEQLMQL
     AVDCAGFSAA EADQLRRAMG SKRSTERMRR LRGRFYDGMR ALHGAPDEVI DRIYEKLEAF
     ANFGFPESHA LSFASLVFYS AWFKLHHPAA FCAALLRAQP MGFYSPQSLV ADARRHGVAV
     HGPCVNASLA HATCENAGTE VRLGLGAVRY LGAELAEKLV AERTANGPFT SLPDLTSRVQ
     LSVPQVEALA TAGALGCFGM SRREALWAAG AAATGRPDRL PGVGSSSHIP ALPGMSELEL
     AAADVWATGV SPDSYPTQFL RADLDAMGVL PAERLGSVSD GDRVLIAGAV THRQRPATAQ
     GVTFINLEDE TGMVNVLCTP GVWARHRKLA HTAPALLIRG QVQNASGAIT VVAERMGRLT
     LAVGARSRDF R
//