NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Rowbotham-Bradford;
DOI=10.1126/science.1101485; PubMed=15486256 [NCBI, ExPASy, EBI, Israel, Japan]
Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M.;
"The 1.2-megabase genome sequence of Mimivirus.";
Science 306:1344-1350(2004).

[2]

IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND SUBCELLULAR LOCATION.
DOI=10.1128/JVI.00940-06; PubMed=16971431 [NCBI, ExPASy, EBI, Israel, Japan]
Renesto P., Abergel C., Decloquement P., Moinier D., Azza S., Ogata H., Fourquet P., Gorvel J.-P., Claverie J.-M., Raoult D.;
"Mimivirus giant particles incorporate a large fraction of anonymous and unique gene products.";
J. Virol. 80:11678-11685(2006).

Comments

FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity).
CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
SUBCELLULAR LOCATION: Virion.
SIMILARITY: Belongs to the RNA polymerase beta' chain family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY653733; AAQ09585.2; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_142855.1; -.

3D structure databases

ModBase

Q7T6X5.

Ontologies

GO:0019012;	Cellular component: virion (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR000722; RNA_pol_A.
IPR006592; RNA_pol_N.
IPR007080; RNA_pol_Rpb1_1.
IPR007066; RNA_pol_Rpb1_3.
IPR007083; RNA_pol_Rpb1_4.
IPR007081; RNA_pol_Rpb1_5.
IPR007073; RNA_pol_Rpb1_7.
Graphical view of domain structure.

Gene3D

G3DSA:2.40.40.30; RNA_pol_A; 1.
G3DSA:3.90.1120.10; RNA_pol_Rpb1_1; 1.
G3DSA:3.30.1360.90; RNA_pol_Rpb1_7; 1.

Pfam

PF04997; RNA_pol_Rpb1_1; 1.
PF00623; RNA_pol_Rpb1_2; 1.
PF04983; RNA_pol_Rpb1_3; 1.
PF05000; RNA_pol_Rpb1_4; 1.
PF04998; RNA_pol_Rpb1_5; 1.
Pfam graphical view of domain structure.

SMART

SM00663; RPOLA_N; 1.
SMART graphical view of domain structure.

Genome annotation databases

GeneID

3162568; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription; Transferase; Virion.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1495`	`1495`		`DNA-directed RNA polymerase subunit 1.`	`PRO_0000073917`

Sequence information

Length: 1495 AA [This is the length of the unprocessed precursor]

Molecular weight: 169839 Da [This is the MW of the unprocessed precursor]

CRC64: 9439FE6F7B1A91DF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEANKNTYSR LGDTIETVER IEFCINSNES IIRHSAIVDP NGITEAETFN SNNNEPVQGG 

        70         80         90        100        110        120 
VIDKRLGVTE SHLECSTCGE TALRCPGHFG HIKFVEPVFH MGYLIYLKHI LSCICIRCNK 

       130        140        150        160        170        180 
LLVYKNEKEI AALIKNKQGK QRFAEIRSIC KKVTHCQKEN YGCGTPAHKI SIDKRNGNIF 

       190        200        210        220        230        240 
LLAEPVKRTD EYDETGETRK RPQQILTPQL CYDILKSVSD EDCIIMGFDP AKSRPEDMII 

       250        260        270        280        290        300 
LNFPVPPVQV RPSIRAEILS SPTMDDDLTH KLIDIIKSNE NLKNTKGDGS LIKYTSINDD 

       310        320        330        340        350        360 
FMLLQLHVAT FFANDMAGLA RSQQKNKKVT KSMSERLRGK EGRIRGNLMG KRVDMSARTV 

       370        380        390        400        410        420 
ITSDPNIALN EVGVPLIIAK NLTFDEIVTE HNIEYLTQLV KNGKRVYPGA NFVIKHVIDA 

       430        440        450        460        470        480 
EGNESGHIYH LKYVDKPISL KPGDIVKRQL IDGDIVIFNR QPSLHKLSMM GHKCHVIPDN 

       490        500        510        520        530        540 
NLLTFRVNVS VTDPYNADFD GDEMNLHVPQ SIQTATEILL IANASRRFVS PATSNIAIKA 

       550        560        570        580        590        600 
KQDTLMGSYV QTEPDMEIDW RDAMSILMST SVKLDNDIPK YQNVSGKFLY SQIIPEGLNI 

       610        620        630        640        650        660 
TKRKNDKEFQ LKIKNGELTD GTLGKSEISS ILQRIWFQYG SKETQEFIDD AQRMILQFLM 

       670        680        690        700        710        720 
RYGYTVSIKD TVIGEKVNQY IYDLIETKRK ETLAFITEYD NDPYVMTKDA FEIKLQENLK 

       730        740        750        760        770        780 
SVQDEIKNTV MRNFDKNSGI FIAISSGSSG EPMNAGQIAG CIGQVIVEGK RIQIRFNGRT 

       790        800        810        820        830        840 
LPMFPKFDDS AFSRGFCRNS FIEGLGPFEF FFQVMAGREG IINTAIKTAD TGYIQRKLVK 

       850        860        870        880        890        900 
MLEDIKQEYD GTVRNANGKL ISCVYGDNGI NTENQVDQKI DLISANDNKV RNDYVYTEDE 

       910        920        930        940        950        960 
IKYLIKNHKT DKRYTTDLNN SLYRKLISMR DQLRRIQRLV NLTSAEFKET YKMPVDIQQF 

       970        980        990       1000       1010       1020 
IFNIINRDVR NNNVVVDPYY VLKMIKDMYY GSDSKIMKYN NRTSRIKKED EKRIKFLMKI 

      1030       1040       1050       1060       1070       1080 
YLYDVLAPKK CTHVYKFSKQ EFDEIVDYFK KTIMLAKVEG GEMVGFVAAQ SIGEPVTQTN 

      1090       1100       1110       1120       1130       1140 
LKSFHKSGTG KTVSGGLVRV KELLGISKNI KTPITEIILE EKYKNDKITA SRIASYLKYT 

      1150       1160       1170       1180       1190       1200 
TLRDVVEKAD VIYDPEPFSK DGLMKKDGVD NIFDQEQGKT GCQTDIKNLP WVLRIMLSKE 

      1210       1220       1230       1240       1250       1260 
KMIERNINML EIKTSFCRNW GTRNEDKTSK KEFNKVIDKI TQCAIVTNYD NSQVPIVHVR 

      1270       1280       1290       1300       1310       1320 
FDANNYNLNT LIQFQEMVIN TYKIKGISNI TESNNIIEES YVDFDDEGNV VKKKQYVIIA 

      1330       1340       1350       1360       1370       1380 
EGINLSEMSQ INGIDLLRTK CNDIVTIYEM YGVEAARTAF IKEFTAAIES SGGFSNYQHI 

      1390       1400       1410       1420       1430       1440 
EILADAITHM GGLIPVNRHG ANKLDTDPFS RASFEKTVEQ LLAAAVFGES DHMRSVSARI 

      1450       1460       1470       1480       1490 
MVGALINGGT GCFDLLLDHK KIQQSLVESE EVVAPVVPIK KKTVLDDLIS KKKSK

Q7T6X5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools