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[1]
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NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 194-207, GLYCOSYLATION, AND SUBUNIT.
TISSUE=Venom, and Venom gland;
DOI=10.1016/j.bbapap.2004.07.007; PubMed=15450849 [NCBI, ExPASy, EBI, Israel, Japan]
Siigur E.,
Aaspollu A.,
Trummal K.,
Tonismaegi K.,
Tammiste I.,
Kalkkinen N.,
Siigur J.;
"Factor X activator from Vipera lebetina venom is synthesized from different genes.";
Biochim. Biophys. Acta 1702:41-51(2004).
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[2]
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FUNCTION, SUBUNIT, AND GLYCOSYLATION.
TISSUE=Venom;
DOI=10.1016/S0304-4165(01)00206-9; PubMed=11731090 [NCBI, ExPASy, EBI, Israel, Japan]
Siigur E.,
Tonismagi K.,
Trummal K.,
Samel M.,
Vija H.,
Subbi J.,
Siigur J.;
"Factor X activator from Vipera lebetina snake venom, molecular characterization and substrate specificity.";
Biochim. Biophys. Acta 1568:90-98(2001).
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- FUNCTION: Catalytic subunit of coagulation factor X-activating enzyme, a zinc-protease enzyme that acts in hemorrhage. Activates coagulation factor X (F10) by cleaving the Arg-Ile bond at position 234, activates coagulation factor IX (F9) by cleaving the Arg-Val bond at position 226 and is also able to activate protein C.
- CATALYTIC ACTIVITY: Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of Arg-|-Xaa bonds. Has no action on insulin B chain.
- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
- SUBUNIT: Heterotrimer; disulfide-linked. The heterotrimer consists of 1 heavy chain and 2 light chains: LC1 and LC2.
- SUBCELLULAR LOCATION: Secreted.
- TISSUE SPECIFICITY: Expressed by the venom gland.
- PTM: N-glycosylated.
- SIMILARITY: Belongs to the snake venom metalloproteinase family. P-III subfamily.
- SIMILARITY: Contains 1 disintegrin domain.
- SIMILARITY: Contains 1 peptidase M12B domain [view classification].
- CAUTION: According to the current nomenclature, this heterotrimer is a member of the P-IV subfamily. This classification is due to the quaternary structure, where two C-type lectin-like proteins are connected to the main chain of the P-III subfamily by disulfide bonds.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 612 AA [This is the length of the unprocessed precursor] |
Molecular weight: 68775 Da [This is the MW of the unprocessed precursor] |
CRC64: C61B42CC9AC00DC1 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MMQVLLVTIS LAVFPYQGSS IILESGNVND YEVVYPQKIT ALPEEAVQQP EQKYEDTMQY
70 80 90 100 110 120
EFEVNGEPVV LHLEKNKDLF SEDYSETRYS PDGRETTTKP PVQDHCYYHG RIQNDAYSSA
130 140 150 160 170 180
SISACNGLKG HFKLQGETYL IEPLKIPDSE AHAVYKYENI EKEDEAPKMC GVTQTNWESD
190 200 210 220 230 240
EPIKKASQLV ATSAKRKFHK TFIELVIVVD HRVVKKYDSA ATNTKIYEIV NTVNEIFIPL
250 260 270 280 290 300
NIRLTLIGVE FWCNRDLINV TSSADDTLDS FGEWRGSDLL NRKRHDNAQL FTDMKFDLST
310 320 330 340 350 360
LGITFLDGMC QAYRSVGIVQ EHGNKNFKTA VIMAHELGHN LGMYHDRKNC ICNDSSCIMS
370 380 390 400 410 420
AVLSSQPSKL FSNCSNHDYR RYLTTYKPKC ILNPPLRKDI ASPPICGNEI WEEGEECDCG
430 440 450 460 470 480
SPKDCQNPCC DAATCKLTPG AECGNGLCCE KCKIKTAGTV CRRARDECDV PEHCTGQSAE
490 500 510 520 530 540
CPADGFHANG QPCQNNNGYC YNGDCPIMTK QCISLFGSRA TVAEDSCFQE NQKGSYYGYC
550 560 570 580 590 600
RKENGRKIPC APQDIKCGRL YCLDNSPGNK NPCKMHYRCR DQHKGMVEPG TKCEDGKVCN
610
NKRQCVDVNT AY
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Q7T046 in FASTA format |
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