FUNCTION: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine (By similarity).
CATALYTIC ACTIVITY: S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.
SUBUNIT: Monomer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the methyltransferase superfamily. HNMT family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC054281; AAH54281.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001080614.1; -.

UniGene

Xl.24624

3D structure databases

HSSP

P50135; 1JQD. [HSSP ENTRY / PDB]

ModBase

Q7SYS9.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0046539;	Molecular function: histamine N-methyltransferase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR016673; Histamine_N-methyltransferase.
Graphical view of domain structure.

PIRSF

PIRSF016616; HHMT; 1.

Genome annotation databases

GeneID

380306; -.

KEGG

xla:380306; -.

Phylogenomic databases

HOVERGEN

Q7SYS9; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Methyltransferase; S-adenosyl-L-methionine; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 293`	`293`	`Histamine N-methyltransferase B.`	`PRO_0000271427`
`BINDING`	`28 28`		`Substrate (By similarity).`
`BINDING`	`60 60`		`S-adenosyl-L-methionine; via carbonyl oxygen (By similarity).`
`BINDING`	`89 89`		`S-adenosyl-L-methionine (By similarity).`
`BINDING`	`94 94`		`S-adenosyl-L-methionine (By similarity).`
`BINDING`	`120 120`		`S-adenosyl-L-methionine; via amide nitrogen (By similarity).`
`BINDING`	`142 142`		`S-adenosyl-L-methionine; via carbonyl oxygen (By similarity).`
`BINDING`	`283 283`		`Substrate (By similarity).`

Sequence information

Length: 293 AA [This is the length of the unprocessed precursor]

Molecular weight: 33060 Da [This is the MW of the unprocessed precursor]

CRC64: A9ACB64AA1F48BB3 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDSGLRSLLS DHSRYVESFR LFLQNSTEHQ CMQHFIETKL PDIISSIGND KPVIDVLGIG 

        70         80         90        100        110        120 
SGSGEIDLQM IAKIQARWPG VSINNQIVEP SAEQILGYKE RVAKAPNLGY VTFSWHHQTS 

       130        140        150        160        170        180 
SEFEHRVTED KQMTKYDFIH MIQMLYYVKD VPGTLKFFKS CLAPNGKLLI ILVSGNSGWA 

       190        200        210        220        230        240 
PLWKKYGQRL PLNDLCLYVT AGDIAEMLSS MGARFQSHEL QSDMDITKCF IEGDKNGELL 

       250        260        270        280        290 
LDFLTETCDF RKNAPAELRD QIICDLKSPR CSTTKDGKVI FNNNLSVIVV EAD

Q7SYS9 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools