[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=Tuebingen; The Danio rerio sequencing project at the Sanger Institute; Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=AB; NIH - Zebrafish Gene Collection (ZGC) project; Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor (By similarity).
CATALYTIC ACTIVITY: ATP + uridine = ADP + UMP.
CATALYTIC ACTIVITY: ATP + cytidine = ADP + CMP.
PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3 .
PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1 .
SIMILARITY: Belongs to the uridine kinase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BX927144; CAQ13314.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC054665; AAH54665.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_956234.1; -.
XP_001918844.1; -.

UniGene

Dr.116070

3D structure databases

SMR

Q7SYM0; 21-233.

ModBase

Q7SYM0.

Organism-specific databases

ZFIN

ZDB-GENE-030131-7158; uck2a.

Gene expression databases

ArrayExpress

Q7SYM0; -.

Ontologies

GO:0004849;	Molecular function: uridine kinase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR006083; PRK_URK.
IPR000764; Uridine_kin.
Graphical view of domain structure.

PANTHER

PTHR10285:SF6; Uridine_kin; 1.

Pfam

PF00485; PRK; 1.
Pfam graphical view of domain structure.

PRINTS

PR00988; URIDINKINASE.

TIGR00235; udk; 1.

Genome annotation databases

Ensembl

ENSDARG00000006074; Danio rerio. [Contig view]

GeneID

100005763; -.
335218; -.

KEGG

dre:100005763; -.
dre:335218; -.

Phylogenomic databases

HOGENOM

Q7SYM0; -.

HOVERGEN

Q7SYM0; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 261`	`261`	`Uridine-cytidine kinase 2-A.`	`PRO_0000346104`
`NP_BIND`	`29 37`	`9`	`ATP (By similarity).`
`BINDING`	`86 86`		`Substrate (By similarity).`
`BINDING`	`114 114`		`Substrate (By similarity).`
`BINDING`	`119 119`		`Substrate (By similarity).`
`BINDING`	`168 168`		`Substrate (By similarity).`
`BINDING`	`178 178`		`Substrate (By similarity).`
`BINDING`	`186 186`		`Substrate (By similarity).`
`BINDING`	`215 215`		`ATP (By similarity).`

Sequence information

Length: 261 AA [This is the length of the unprocessed precursor]

Molecular weight: 29628 Da [This is the MW of the unprocessed precursor]

CRC64: 460C3C02A024490B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAGDSDSKLD NHAENEHVDW QPFLIGVAGG TASGKSSVCG KIMELLGQNK IDHHQRQVAI 

        70         80         90        100        110        120 
LSQDSFYRVL TPEQKAKALK GQFNFDHPDA FDNELIVKTL CEIMEGRTVQ IPVYDFVTHS 

       130        140        150        160        170        180 
RKEETVTVYP ADVVLFEGIL MFYSQEIRDL FQMKLFVDTD ADTRLSRRVL RDISERGRDL 

       190        200        210        220        230        240 
EQVLNQYITF VKPAFEEFCL PTKKYADVII PRGADNLVAI NLIVQHIQDF LNGGLTKRLN 

       250        260 
GCLNGHTPRK RHPSESSSRP H

Q7SYM0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools