[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=AB; NIH - Zebrafish Gene Collection (ZGC) project; Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H₂O = N-formimidoyl-L-glutamate + H⁺.
COFACTOR: Binds 1 zinc or iron ion per subunit (By similarity).
PATHWAY: Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3 .
SIMILARITY: Belongs to the hutI family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC055559; AAH55559.1; ALT_INIT; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

UniGene

Dr.104637

3D structure databases

ModBase

Q7SXK5.

Ontologies

GO:0050480;	Molecular function: imidazolonepropionase activity (inferred from electronic annotation from EC).
GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008270;	Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR006680; Amidohydro_1.
IPR005920; HutI.
Graphical view of domain structure.

Pfam

PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.

ProDom

PD001248; Amidohydro_like; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGR01224; hutI; 1.

Genome annotation databases

Ensembl

ENSDARG00000007366; Danio rerio. [Contig view]

Phylogenomic databases

HOVERGEN

Q7SXK5; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Histidine metabolism; Hydrolase; Iron; Metal-binding; Zinc.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 433`	`433`	`Probable imidazolonepropionase.`	`PRO_0000282584`
`METAL`	`88 88`		`Zinc or iron (By similarity).`
`METAL`	`90 90`		`Zinc or iron (By similarity).`
`METAL`	`261 261`		`Zinc or iron (By similarity).`
`METAL`	`335 335`		`Zinc or iron (By similarity).`
`BINDING`	`97 97`		`Substrate (By similarity).`
`BINDING`	`110 110`		`Substrate (By similarity).`
`BINDING`	`160 160`		`Substrate (By similarity).`
`BINDING`	`193 193`		`Substrate (By similarity).`
`BINDING`	`264 264`		`Substrate (By similarity).`

Sequence information

Length: 433 AA [This is the length of the unprocessed precursor]

Molecular weight: 46904 Da [This is the MW of the unprocessed precursor]

CRC64: 6E818B948306DE19 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSANSFKLLV KNATQLVLVC RNGEKYLTRD EMQALAVLEN ASVLIGHDGL IKAVGPADVI 

        70         80         90        100        110        120 
ETQFEGAKFD NVLDASGMCV LPGLVDAHTH PVWAGDRVHE FAMKLAGATY MEVHEAGGGI 

       130        140        150        160        170        180 
HFTVAHTRSA SEQHLLAALK SRLERMMRAG TTLVECKSGY GLELDIEVKM LRVINSARKS 

       190        200        210        220        230        240 
LPIGISATYC GAHAVPKGKT MEEATKDIVA VQLPKIKHLS ASGDLQVDNI DVFCEKGVFD 

       250        260        270        280        290        300 
LTSTRCILQA GKDMGLNINF HGDELHPMNS AHLGAELGAL AISHLEEVTD DGIVAMAKSK 

       310        320        330        340        350        360 
TSAVLLPTTA YILRLTPPRA RDMLDAGVIV ALGSDFNPNA YCFSMPMVMH LACVMMKMSM 

       370        380        390        400        410        420 
PEALAASTIN AAYALNRSQT HGSLEVGKQG DLVIINAPRW EHLVYQFGGH QELIRYVIIK 

       430 
GDFVYENDKV LNL

Q7SXK5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools