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UniProtKB/Swiss-Prot entry Q7SB53


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MCE1_NEUCR
Primary accession number Q7SB53
Secondary accession numbers None
Integrated into Swiss-Prot on September 27, 2004
Sequence was last modified on December 15, 2003 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 36)
Name and origin of the protein
Protein name mRNA-capping enzyme subunit alpha
Synonyms mRNA guanylyltransferase
EC 2.7.7.50
GTP--RNA guanylyltransferase
GTase
Gene name
ORFNames: NCU06260
From
Neurospora crassa [TaxID: 5141] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AABX02000025; EAA33628.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_962864.1; -.
3D structure databases
ModBase Q7SB53.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR017075; mRNA_cap_enz_asu.
IPR001339; mRNA_cap_enzyme.
IPR013846; mRNA_cap_enzyme_C.
IPR012340; NA-bd_OB-fold.
Graphical view of domain structure.
Gene3D G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
Pfam PF03919; mRNA_cap_C; 1.
PF01331; mRNA_cap_enzyme; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036959; mRNA_cap_alpha; 1.
BLOCKS Q7SB53.
ProtoNet Q7SB53.
Genome annotation databases
GeneID 3879017; -.
KEGG ncr:NCU06260; -.
NMPDR fig|5141.1.peg.4048; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; mRNA capping; mRNA processing; Nucleotidyltransferase; Nucleus; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   402  402     mRNA-capping enzyme subunit alpha. PRO_0000210103
ACT_SITE   66    66        N6-GMP-lysine intermediate (By similarity). 
Sequence information
Length: 402 AA [This is the length of the unprocessed precursor] Molecular weight: 46572 Da [This is the MW of the unprocessed precursor] CRC64: 9A3862BF446C0F60 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEQPGPITDI AKPGIKAPRD LAISLREEVA RILGRSSIGF PGAQPVSFAR KHLEELRRED 

        70         80         90        100        110        120 
YYVCEKSDGI RYLLYLTVDE EGQEVQYLID RKNDYWFLPR NSMHFPMPND IQAFHRGTII 

       130        140        150        160        170        180 
DGELVMDTVP GTNGRKEPRF LVFDLLALDD KAELLNKPLD KRLGYFSAYI YEPYKKLLQQ 

       190        200        210        220        230        240 
FPQEIPFMAF KVEMKRMELS YGIETMFREV IPALKHDSDG LIFTCRTTPY HFGTDPHILK 

       250        260        270        280        290        300 
WKAPHENTLD FRMRLNFPLV QATEAELDEG FPEQFTDYDS VPQAELYVFC GNDGPGGSKY 

       310        320        330        340        350        360 
ELFPDPLYIA EDEWETLKAL GDPLQDRVVE CCLDAENRWR LFRFRDDKNE ANHTSTVSSV 

       370        380        390        400 
MASIRDGVSD QELLSAATAI KESWKIRAQK RKEQQQQQQP KH 

Q7SB53 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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NPSA logo NPSA Sequence analysis tools

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