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UniProtKB/Swiss-Prot entry Q7SB49


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DNL4_NEUCR
Primary accession number Q7SB49
Secondary accession numbers None
Integrated into Swiss-Prot on February 20, 2007
Sequence was last modified on December 15, 2003 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 37)
Name and origin of the protein
Protein name DNA ligase 4
Synonyms EC 6.5.1.1
DNA ligase IV
Polydeoxyribonucleotide synthase [ATP] 4
DNA repair and recombination protein mus-53
Gene name
Name: lig-4
Synonyms: mus-53
ORFNames: NCU06264
From
Neurospora crassa [TaxID: 5141] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
DOI=10.1073/pnas.0604477103; PubMed=17003123 [NCBI, ExPASy, EBI, Israel, Japan]
Ishibashi K., Suzuki K., Ando Y., Takakura C., Inoue H.;
"Nonhomologous chromosomal integration of foreign DNA is completely dependent on MUS-53 (human Lig4 homolog) in Neurospora.";
Proc. Natl. Acad. Sci. U.S.A. 103:14871-14876(2006).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB261106; BAF34364.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AABX02000025; EAA33632.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_962868.1; -.
3D structure databases
ModBase Q7SB49.
Family and domain databases
InterPro IPR001357; BRCT.
IPR000977; DNA_ligase.
IPR012309; DNA_ligase_A_C.
IPR012310; DNA_ligase_A_M.
IPR016059; DNA_ligase_CS.
IPR012340; NA-bd_OB-fold.
Graphical view of domain structure.
Gene3D G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
Pfam PF00533; BRCT; 3.
PF04679; DNA_ligase_A_C; 1.
PF01068; DNA_ligase_A_M; 1.
Pfam graphical view of domain structure.
SMART SM00292; BRCT; 2.
SMART graphical view of domain structure.
TIGRFAMs TIGR00574; dnl1; 1.
PROSITE PS50172; BRCT; 2.
PS00697; DNA_LIGASE_A1; 1.
PS50160; DNA_LIGASE_A3; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q7SB49.
Genome annotation databases
GeneID 3879007; -.
KEGG ncr:NCU06264; -.
NMPDR fig|5141.1.peg.4052; -.
Other
ProtoNet Q7SB49.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding; Nucleus; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   1046  1046     DNA ligase 4. PRO_0000278384
DOMAIN   738    836  99     BRCT 1. 
DOMAIN   932   1045  114     BRCT 2. 
ACT_SITE   327    327        N6-AMP-lysine intermediate (By similarity). 
Sequence information
Length: 1046 AA [This is the length of the unprocessed precursor] Molecular weight: 118910 Da [This is the MW of the unprocessed precursor] CRC64: 072B0B5B806A3146 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNTNRRSRSP DEEALEEDQH QYGAGTLSLE ELDEQPRNHS KTFPFSDLFR TLFNPLIDCK 

        70         80         90        100        110        120 
PSTSGGTVRG PKPGRGGHFS KVSYHEQRRH IIERFMSRWR SEVGNDFYPA MRLILPDKDR 

       130        140        150        160        170        180 
DRGVYGLKEN TIGKLLVKVM KIDRNSEDGY NLMHWKLPGG QSGVSRSVGD FAGRCLEVVS 

       190        200        210        220        230        240 
KRAMRAQPGD LTIADVNVLL DRLAAASGEA EQLPIFEEFY RQMNAEEMMW LVRIILKDMR 

       250        260        270        280        290        300 
VGATERTFLN LWHPDAEALF SVSSSLRRVC WELFDPEFRL EQQETGIKLM QCFQPQLAQF 

       310        320        330        340        350        360 
QMTTTWEKLV KNLGVTEENP EFWIEEKLDG ERMQMHMIED DTVPGGFRFA FWSRKAKDYT 

       370        380        390        400        410        420 
YLYGESLGDE QSALTRHLHK AFDDGVRNLI LDGEMITWDI DIDKMVPFGT LKTAALEQQK 

       430        440        450        460        470        480 
NPSKAGPRPL YRVFDILLLN DKPLTEYTLN DRRRALERAV VGVHRRLEIL PFERATSPDA 

       490        500        510        520        530        540 
IEPLLRRVVA EASEGLVLKN PRSRYSLNSR NNDWIKVKPE YMSDFGESLD CVVVGGYFGS 

       550        560        570        580        590        600 
GRRGGTLSSF LCGVRVSQNF IKSGNASAEK CLSFVKVGGG FKAEDYAEIR HHTEGKWQDW 

       610        620        630        640        650        660 
DPSSPPTEYI ELGGGEKLQY EKPDVWIRPS DSVVISVKAA SITQSDQFAM GWTLRFPRFR 

       670        680        690        700        710        720 
KLRLDRAWDS ALDMDEFEVL RSKIKDQEQE RKKMEMENRK RKPATKRARK DLVIAGMSDP 

       730        740        750        760        770        780 
SSSSAATPVI APKETREASK RLFEGLDFCV LSDSLKPNKM TKPALEKLIK DHGGRIHQQV 

       790        800        810        820        830        840 
MDHSGQGKII IPIADKNVIK VASLRKANPE MDIIRPKWIF DCLVQPMPFT KQKENKKGYL 

       850        860        870        880        890        900 
LPFEPTHLFH SGSEETSEEA EQAVDKFGDS YAGDLADINE LKAIMEGMES DDYVSDSDWD 

       910        920        930        940        950        960 
SDSGRGRGGG DGFDMNHFLD HLEEQGTSLD DLRSFMFRRC RVFFALPSAG NGDGAAESKA 

       970        980        990       1000       1010       1020 
LRLKNYIRFG NGKVVDELET ATHVVVVTAP LGESSKKEER EIAAELRYKI SLREMGSPMP 

      1030       1040 
RIVKGEWVED SWKEGTVVDE EEYVAG 

Q7SB49 in FASTA format

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View entry in raw text format (no links)
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