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UniProtKB/Swiss-Prot entry Q7RXL1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NCB5R_NEUCR
Primary accession number Q7RXL1
Secondary accession numbers None
Integrated into Swiss-Prot on April 29, 2008
Sequence was last modified on December 15, 2003 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 34)
Name and origin of the protein
Protein name NADH-cytochrome b5 reductase 1
Synonyms EC 1.6.2.2
Microsomal cytochrome b reductase
Gene name
Name: cbr-1
ORFNames: NCU00216
From
Neurospora crassa [TaxID: 5141] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AABX02000001; EAA27365.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_956601.1; -.
3D structure databases
HSSP P17571; 1CNF. [HSSP ENTRY / PDB]
ModBase Q7RXL1.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005741; Cellular component: mitochondrial outer membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0004128; Molecular function: cytochrome-b5 reductase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001834; Cyt_B5_reductase.
IPR001709; FPN_cyt_redctse.
IPR008333; OxRdtase_FAD-bd.
IPR001433; OxRdtase_FAD/NAD_bd.
Graphical view of domain structure.
Pfam PF00970; FAD_binding_6; 1.
PF00175; NAD_binding_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00406; CYTB5RDTASE.
PR00371; FPNCR.
PROSITE PS51384; FAD_FR; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q7RXL1.
ProtoNet Q7RXL1.
Genome annotation databases
GeneID 3872748; -.
KEGG ncr:NCU00216; -.
NMPDR fig|5141.1.peg.235; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Endoplasmic reticulum; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion outer membrane; NAD; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   310  310     NADH-cytochrome b5 reductase 1. PRO_0000330160
TRANSMEM   33    50  18     Potential. 
DOMAIN   61   169  109     FAD-binding FR-type. 
NP_BIND   149   164  16     FAD (By similarity). 
NP_BIND   175   209  35     FAD (By similarity). 
Sequence information
Length: 310 AA [This is the length of the unprocessed precursor] Molecular weight: 34001 Da [This is the MW of the unprocessed precursor] CRC64: AD00607089CF7B40 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSEESLLERK YFDGIYIPAG LLVFGTVIVK KEWTLYAALA ALILGAIKYF RMLPKKVLKP 

        70         80         90        100        110        120 
AVFQEFELKE KTIISHNVAI YRFKLPTPDS VLGLPIGQHI SIGAAIEQPD GSTKEIVRSY 

       130        140        150        160        170        180 
TPISGDHQPG YFDLLIKSYP TGNISKHMAS LQVGQTIRVK GPKGAFVYTP NMVRHFGMVA 

       190        200        210        220        230        240 
GGTGITPMLQ VIRAIVRGRA AGDRTEVDLI FANVTAQDIL LKEDLDALVA QDKGIRVHYV 

       250        260        270        280        290        300 
LDRPPEGWTG GVGFVTQEMV EKLLPKPASD VKILLCGPPP MISGLKKATE ALGFQKARPV 

       310 
SKLEDQVFAF 

Q7RXL1 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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