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UniProtKB/Swiss-Prot entry Q7RVY5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HEM1_NEUCR
Primary accession number Q7RVY5
Secondary accession numbers None
Integrated into Swiss-Prot on September 27, 2004
Sequence was last modified on December 4, 2007 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 42)
Name and origin of the protein
Protein name 5-aminolevulinate synthase, mitochondrial [Precursor]
Synonyms EC 2.3.1.37
5-aminolevulinic acid synthase
Delta-aminolevulinate synthase
Delta-ALA synthetase
Gene name
Name: hem-1
ORFNames: NCU06189
From
Neurospora crassa [TaxID: 5141] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AABX02000025; EAA33765.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_963001.2; -.
3D structure databases
ModBase Q7RVY5.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
GO:0006783; Biological process: heme biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR010961; 4pyrrol_synth_NH2levulA_synth.
IPR004839; Aminotrans_I/II.
IPR001917; Aminotrans_II_pyridoxalP_BS.
IPR015421; PyrdxlP-dep_Trfase_major_sub1.
Graphical view of domain structure.
Gene3D G3DSA:3.40.640.10; PyrdxlP-dep_Trfase_major_sub1; 2.
Pfam PF00155; Aminotran_1_2; 2.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01821; 5aminolev_synth; 1.
PROSITE PS00599; AA_TRANSFER_CLASS_2; 1.
BLOCKS Q7RVY5.
ProtoNet Q7RVY5.
Genome annotation databases
GeneID 3879149; -.
KEGG ncr:NCU06189; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acyltransferase; Complete proteome; Heme biosynthesis; Mitochondrion; Pyridoxal phosphate; Transferase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    69  69     Mitochondrion (Potential). 
CHAIN   70   629  560     5-aminolevulinate synthase, mitochondrial. PRO_0000001242
BINDING   391   391        Pyridoxal phosphate (covalent) (By similarity). 
Sequence information
Length: 629 AA [This is the length of the unprocessed precursor] Molecular weight: 67447 Da [This is the MW of the unprocessed precursor] CRC64: 01FA359E33FFEF00 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDSVLRQSKA VCPFMKKATA SSLRAMTTAA RPAASPCGGA ISKLQVLAHR CPVMGKAMAV 

        70         80         90        100        110        120 
QSARTGGRAS AAPASFVHKA KLHTGRPREA QAVEGVFTGQ KAGLPPHPPV KPTTATAANP 

       130        140        150        160        170        180 
SPAACTVSGN FGTKFNYEKF YENELEKKHK DKSYRYFNNI NRLAKDFPRA HMATKEEKVA 

       190        200        210        220        230        240 
VWCANDYLGM GRNKHVLEAM HTTLDEYGAG AGGTRNISGH NKHAVELENS LAKLHATDAA 

       250        260        270        280        290        300 
LVFSSCYVAN DATLATLGSK LPDCVILSDS LNHASMIQGI RHSGAKKIIF KHNDVEDLEK 

       310        320        330        340        350        360 
KLAALPLHIP KIIAFESVYS MCGSIGPIEK FCDLAEKYGA ITFNDEVHAV GMYGPHGAGV 

       370        380        390        400        410        420 
AEHLDWEAHQ RGETKGTIAD RIDIYSGTLG KAYGCVGGYI AGSAKLVDTI RSLAPGFIFT 

       430        440        450        460        470        480 
TTLPPAVMAG ARAAIEYQMS YDGDRRLQQL HTRAVKEALA DRDIPVIPNP SHIIPILVGN 

       490        500        510        520        530        540 
AELAKKASDK LLNDHQIYVQ SINYPTVPVG QERLRITPTP GHTKQFRDHL VAALDSIWTE 

       550        560        570        580        590        600 
LGIKRTSDWA AEGGFIGVGE AEAEPVAPLW TDEQLGIADA VAELRAQASD EKKGVINQLL 

       610        620 
ESVALEQERE ALNAAEEVAD AAKAAAASA 

Q7RVY5 in FASTA format

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