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UniProtKB/Swiss-Prot entry Q7RVA8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KPYK_NEUCR
Primary accession number Q7RVA8
Secondary accession numbers None
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on December 15, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 37)
Name and origin of the protein
Protein name Pyruvate kinase
Synonyms PK
EC 2.7.1.40
Gene name
Name: pyk-1
ORFNames: NCU06075
From
Neurospora crassa [TaxID: 5141] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AABX02000021; EAA30602.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_959838.1; -.
3D structure databases
ModBase Q7RVA8.
Family and domain databases
InterPro IPR001697; Pyr_Knase.
IPR015813; Pyrv/PenolPyrv_Kinase_cat.
IPR015794; Pyrv_Knase_a/b.
IPR015793; Pyrv_Knase_brl.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.60; Pyrv/PenolPyrv_Kinase_cat; 1.
G3DSA:3.40.1380.20; Pyrv_Knase_a/b; 1.
PANTHER PTHR11817; Pyruvate_kinase; 1.
Pfam PF00224; PK; 1.
PF02887; PK_C; 1.
Pfam graphical view of domain structure.
PRINTS PR01050; PYRUVTKNASE.
ProDom PD001009; Pyruvate_kinase; 2.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01064; pyruv_kin; 1.
PROSITE PS00110; PYRUVATE_KINASE; 1.
BLOCKS Q7RVA8.
ProtoNet Q7RVA8.
Genome annotation databases
GeneID 3875985; -.
NMPDR fig|5141.1.peg.3863; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glycolysis; Kinase; Magnesium; Metal-binding; Pyruvate; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   527  527     Pyruvate kinase. PRO_0000112115
ACT_SITE   253   253        By similarity. 
METAL   255   255        Magnesium (Potential). 
METAL   276   276        Magnesium (Potential). 
METAL   277   277        Magnesium (Potential). 
BINDING   350   350        ADP (Potential). 
Sequence information
Length: 527 AA [This is the length of the unprocessed precursor] Molecular weight: 57870 Da [This is the MW of the unprocessed precursor] CRC64: 0193D192F0CBA18B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAATALDHLS LGGKIQWLAQ LNTEFQPARE FRRTSIICTI GPKTNSVEAI NKLRDAGLNV 

        70         80         90        100        110        120 
VRMNFSHGSY EYHQSVIDNA RQAEKVHPGR PIAIALDTKG PEIRTGNTKN DEDIPISAGT 

       130        140        150        160        170        180 
ILNITTDEKY KDECTIEHMY VDYVNITKVI APGRIIYVDD GVLAFEVLEI VDDKTIKVKA 

       190        200        210        220        230        240 
RNNGYISSRK GVNLPNTDVD LPALSEKDKA DLRFGVKNKV DMVFASFIRR GQDIKDIREV 

       250        260        270        280        290        300 
LGEDGKQIQI IAKIENRQGL NNFAEILAET DGVMVARGDL GIEIPAAEVF AAQKKIIAMC 

       310        320        330        340        350        360 
NIAGKPVICA TQMLESMIKN PRPTRAEISD VGNAVTDGAD CVMLSGETAK GAYPTEAVRE 

       370        380        390        400        410        420 
MSEAVLKAEN TIPYVSHFEE LCSLAKRPVS IVESCAMASV RASLDLNAAA ILVLSTSGES 

       430        440        450        460        470        480 
ARLISKYRPV CPIIMITRND SASRYAHLYR GVYPFLFPES KPDFSKVNWQ EDVDRRIKWG 

       490        500        510        520 
LSHGIGLKVL NEGETVVVVQ GWKGGMGNTN TFRIVKADVN HLGLGQP 

Q7RVA8 in FASTA format

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