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UniProtKB/Swiss-Prot entry Q7RTZ2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name U17L1_HUMAN
Primary accession number Q7RTZ2
Secondary accession numbers None
Integrated into Swiss-Prot on October 17, 2006
Sequence was last modified on December 15, 2003 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 27)
Name and origin of the protein
Protein name Ubiquitin carboxyl-terminal hydrolase 17-like protein 1
Synonyms EC 3.1.2.15
Ubiquitin thioesterase 17-like protein 1
Ubiquitin-specific-processing protease 17-like protein 1
Deubiquitinating enzyme 17-like protein 1
Gene name
Name: USP17L1
Synonyms: USP17L
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04406; PubMed=16421571 [NCBI, ExPASy, EBI, Israel, Japan]
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.;
"DNA sequence and analysis of human chromosome 8.";
Nature 439:331-335(2006).
[2]
IDENTIFICATION.
DOI=10.1038/nrg1111; PubMed=12838346 [NCBI, ExPASy, EBI, Israel, Japan]
Puente X.S., Sanchez L.M., Overall C.M., Lopez-Otin C.;
"Human and mouse proteases: a comparative genomic approach.";
Nat. Rev. Genet. 4:544-558(2003).
[3]
NOMENCLATURE.
DOI=10.1016/j.ygeno.2004.11.013; PubMed=15780755 [NCBI, ExPASy, EBI, Israel, Japan]
Burrows J.F., McGrattan M.J., Johnston J.A.;
"The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.";
Genomics 85:524-529(2005).
[4]
NOMENCLATURE.
DOI=10.1186/1471-2164-7-292; PubMed=17109758 [NCBI, ExPASy, EBI, Israel, Japan]
Shin J.-M., Yoo K.-J., Kim M.-S., Kim D., Baek K.-H.;
"Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.";
BMC Genomics 7:292-292(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF228730; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
BN000116; CAD66056.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
ModBase Q7RTZ2.
Organism-specific databases
H-InvDB HIX0034676; -.
HIX0058593; -.
HIX0058594; -.
GeneCards Q7RTZ2.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-KW).
GO:0006915; Biological process: apoptosis (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001394; Peptidase_C19.
Graphical view of domain structure.
Pfam PF00443; UCH; 1.
Pfam graphical view of domain structure.
PROSITE PS00972; UCH_2_1; FALSE_NEG.
PS00973; UCH_2_2; 1.
PS50235; UCH_2_3; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q7RTZ2.
ProtoNet Q7RTZ2.
Genome annotation databases
Ensembl ENSG00000206033; Homo sapiens. [Contig view]
Phylogenomic databases
HOVERGEN Q7RTZ2; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Apoptosis; Hydrolase; Nucleus; Protease; Thiol protease; Ubl conjugation pathway.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   530  530     Ubiquitin carboxyl-terminal hydrolase 17-like protein 1. PRO_0000253963
ACT_SITE   89    89        By similarity. 
ACT_SITE   325   325        By similarity. 
ACT_SITE   334   334        By similarity. 
Sequence information
Length: 530 AA [This is the length of the unprocessed precursor] Molecular weight: 59590 Da [This is the MW of the unprocessed precursor] CRC64: 5CCFDA6582338353 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGDDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSSETRVD LCDDLAPVAR 

        70         80         90        100        110        120 
QLAPREKLPL SSRRPAAVGA GLQNMGNTCY ENASLQCLTY TLPLANYMLS REHSQTCQRP 

       130        140        150        160        170        180 
KCCMLCTMQA HITWALHSPG HVIQPSQALA AGFHRGKQED VHEFLMFTVD AMKKACLPGH 

       190        200        210        220        230        240 
KQVDHHCKDT TLIHQIFGGC WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVKQALEQL 

       250        260        270        280        290        300 
VKPEELNGEN AYHCGLCLQR APASNTLTLH TSAKVLILVL KRFSDVAGNK LAKNVQYPEC 

       310        320        330        340        350        360 
LDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HDGHYFSYVK AQEVQWYKMD DAEVTVCSII 

       370        380        390        400        410        420 
SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD RRAKQGELKR DHPCLQAPEL 

       430        440        450        460        470        480 
DEHLVERATQ ESTLDHWKFL QEQNKTKPEF NVGKVEGTLP PNALVIHQSK YKCGMKNHHP 

       490        500        510        520        530 
EQQSSLLNLS STTRTDQESM NTGTLASLQG RTRRAKGKNK HSKRALLVCQ 

Q7RTZ2 in FASTA format

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View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
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