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UniProtKB/Swiss-Prot entry Q7RTX1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TS1R1_HUMAN
Primary accession number Q7RTX1
Secondary accession numbers Q5SY22 Q5SY24 Q8NGZ7 Q8TDJ7 Q8TDJ8 Q8TDJ9 Q8TDK0
Integrated into Swiss-Prot on January 4, 2005
Sequence was last modified on December 15, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 52)
Name and origin of the protein
Protein name Taste receptor type 1 member 1 [Precursor]
Synonym G-protein coupled receptor 70
Gene name
Name: TAS1R1
Synonyms: GPR70, T1R1, TR1
ORFNames: GM148
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes.";
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 65-841 (ISOFORMS 1; 2; 3 AND 4), AND VARIANT GLU-347.
DOI=10.1016/S0378-1119(01)00897-6; PubMed=11891061 [NCBI, ExPASy, EBI, Israel, Japan]
Makalowska I., Sood R., Faruque M.U., Hu P., Robbins C.M., Eddings E.M., Mestre J.D., Baxevanis A.D., Carpten J.D.;
"Identification of six novel genes by experimental validation of GeneMachine predicted genes.";
Gene 284:203-213(2002).
[4]
IDENTIFICATION OF ISOFORM 1, AND FUNCTION.
DOI=10.1073/pnas.072090199; PubMed=11917125 [NCBI, ExPASy, EBI, Israel, Japan]
Li X., Staszewski L., Xu H., Durick K., Zoller M., Adler E.;
"Human receptors for sweet and umami taste.";
Proc. Natl. Acad. Sci. U.S.A. 99:4692-4696(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB065618; BAC05845.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL591866; CAI16073.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL591866; CAI16074.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL591866; CAI16076.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF387617; AAL91358.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF387618; AAL91359.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF387619; AAL91360.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF387620; AAL91361.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BK000153; DAA00012.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_619642.2; -.
NP_803883.1; -.
NP_803884.1; -.
NP_803885.1; -.
UniGene Hs.124574
3D structure databases
ModBase Q7RTX1.
Protein family/group databases
GPCRDB Q7RTX1; TS1R1_HUMAN.
Organism-specific databases
H-InvDB HIX0000082; -.
HGNC HGNC:14448; TAS1R1.
GenAtlas TAS1R1.
MIM 606225; gene. [NCBI / EBI]
PharmGKB PA37882; -.
GeneCards Q7RTX1.
Gene expression databases
ArrayExpress Q7RTX1; -.
CleanEx HS_TAS1R1; -.
GermOnline ENSG00000173662; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred by curator from UniProtKB).
GO:0046982; Molecular function: protein heterodimerization activity (non-traceable author statement from UniProtKB).
GO:0008527; Molecular function: taste receptor activity (inferred from direct assay from UniProtKB).
GO:0050917; Biological process: sensory perception of umami taste (inferred from direct assay from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001828; ANF_lig_bd_rcpt.
IPR000337; GPCR_3.
IPR000068; GPCR_3_Ca_sens_rcpt-rel.
IPR011500; GPCR_3_NCR.
Graphical view of domain structure.
Pfam PF00003; 7tm_3; 1.
PF01094; ANF_receptor; 1.
PF07562; NCD3G; 1.
Pfam graphical view of domain structure.
PRINTS PR00592; CASENSINGR.
PR00248; GPCRMGR.
PROSITE PS00979; G_PROTEIN_RECEP_F3_1; FALSE_NEG.
PS00980; G_PROTEIN_RECEP_F3_2; 1.
PS00981; G_PROTEIN_RECEP_F3_3; 1.
PS50259; G_PROTEIN_RECEP_F3_4; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q7RTX1.
Genome annotation databases
Ensembl ENSG00000173662; Homo sapiens. [Contig view]
GeneID 80835; -.
KEGG hsa:80835; -.
Phylogenomic databases
HOGENOM Q7RTX1; -.
HOVERGEN Q7RTX1; -.
Other
SOURCE TAS1R1; Homo sapiens.
GPCRDB-Snakes Q7RTX1.
ProtoNet Q7RTX1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; Receptor; Sensory transduction; Signal; Taste; Transducer; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    20  20     Potential. 
CHAIN   21   841  821     Taste receptor type 1 member 1. PRO_0000012954
TOPO_DOM   21   567  547     Extracellular (Potential). 
TRANSMEM   568   588  21     1 (Potential). 
TOPO_DOM   589   603  15     Cytoplasmic (Potential). 
TRANSMEM   604   624  21     2 (Potential). 
TOPO_DOM   625   639  15     Extracellular (Potential). 
TRANSMEM   640   660  21     3 (Potential). 
TOPO_DOM   661   680  20     Cytoplasmic (Potential). 
TRANSMEM   681   701  21     4 (Potential). 
TOPO_DOM   702   725  24     Extracellular (Potential). 
TRANSMEM   726   746  21     5 (Potential). 
TOPO_DOM   747   761  15     Cytoplasmic (Potential). 
TRANSMEM   762   782  21     6 (Potential). 
TOPO_DOM   783   795  13     Extracellular (Potential). 
TRANSMEM   796   816  21     7 (Potential). 
TOPO_DOM   817   841  25     Cytoplasmic (Potential). 
CARBOHYD   87    87        N-linked (GlcNAc...) (Potential). 
CARBOHYD   88    88        N-linked (GlcNAc...) (Potential). 
CARBOHYD   95    95        N-linked (GlcNAc...) (Potential). 
CARBOHYD   291   291        N-linked (GlcNAc...) (Potential). 
CARBOHYD   479   479        N-linked (GlcNAc...) (Potential). 
CARBOHYD   529   529        N-linked (GlcNAc...) (Potential). 
VAR_SEQ   167   420        Missing (in isoform 2, isoform 3 and isoform 4). VSP_012418
VAR_SEQ   421   841        LLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPK WTFTVLGSSTWSPVQLNINETKIQWHGKDNQVPKSVCSSD CLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCG KEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLL LLGTAGLFAWHLDTPVVRSAGGRLCFLMLGSLAAGSGSLY GFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIF KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVV WTPLPAREYQRFPHLVMLECTETNSLGFILAFLYNGLLSI SAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTA SVYDGKYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPD LNSTEHFQASIQDYTRRCGST -> LSYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKF GWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMP FSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFES VVLTNLTGKVWVASEAWALSRHITGVPGIQRIGMVLGVAI QKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSSNQLCRE CQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGC ASGACSRGRVYPWQTSTDASLVGKKSGHLREARPASRALW CFWLCVSTPLGCCWQLTRCCCCCCLGLLACLPGT (in isoform 3). VSP_012420
VAR_SEQ   532   574        DLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWV LLAAN -> ATWVRTCQRTTTRTNVSPSACSSTSCPGSPSSPRPAST TAXTC (in isoform 4). VSP_012421
VAR_SEQ   575   841        Missing (in isoform 4). VSP_012422
VARIANT   347   347  1     K -> E (in dbSNP:rs10864628 [NCBI]). VAR_036707 
VARIANT   372   372  1     A -> T (in dbSNP:rs34160967 [NCBI]). VAR_036708 
VARIANT   507   507  1     R -> Q (in dbSNP:rs35118458 [NCBI]). VAR_036709 
CONFLICT   167   167        I -> L (in Ref. 3; AAL91358). 
CONFLICT   550   550        Q -> R (in Ref. 3; CAI16076). 
CONFLICT   648   648        C -> W (in Ref. 3; AAL91360). 
Sequence information
Length: 841 AA [This is the length of the unprocessed precursor] Molecular weight: 93074 Da [This is the MW of the unprocessed precursor] CRC64: E800772B267D0216 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLLCTARLVG LQLLISCCWA FACHSTESSP DFTLPGDYLL AGLFPLHSGC LQVRHRPEVT 

        70         80         90        100        110        120 
LCDRSCSFNE HGYHLFQAMR LGVEEINNST ALLPNITLGY QLYDVCSDSA NVYATLRVLS 

       130        140        150        160        170        180 
LPGQHHIELQ GDLLHYSPTV LAVIGPDSTN RAATTAALLS PFLVPMISYA ASSETLSVKR 

       190        200        210        220        230        240 
QYPSFLRTIP NDKYQVETMV LLLQKFGWTW ISLVGSSDDY GQLGVQALEN QATGQGICIA 

       250        260        270        280        290        300 
FKDIMPFSAQ VGDERMQCLM RHLAQAGATV VVVFSSRQLA RVFFESVVLT NLTGKVWVAS 

       310        320        330        340        350        360 
EAWALSRHIT GVPGIQRIGM VLGVAIQKRA VPGLKAFEEA YARADKKAPR PCHKGSWCSS 

       370        380        390        400        410        420 
NQLCRECQAF MAHTMPKLKA FSMSSAYNAY RAVYAVAHGL HQLLGCASGA CSRGRVYPWQ 

       430        440        450        460        470        480 
LLEQIHKVHF LLHKDTVAFN DNRDPLSSYN IIAWDWNGPK WTFTVLGSST WSPVQLNINE 

       490        500        510        520        530        540 
TKIQWHGKDN QVPKSVCSSD CLEGHQRVVT GFHHCCFECV PCGAGTFLNK SDLYRCQPCG 

       550        560        570        580        590        600 
KEEWAPEGSQ TCFPRTVVFL ALREHTSWVL LAANTLLLLL LLGTAGLFAW HLDTPVVRSA 

       610        620        630        640        650        660 
GGRLCFLMLG SLAAGSGSLY GFFGEPTRPA CLLRQALFAL GFTIFLSCLT VRSFQLIIIF 

       670        680        690        700        710        720 
KFSTKVPTFY HAWVQNHGAG LFVMISSAAQ LLICLTWLVV WTPLPAREYQ RFPHLVMLEC 

       730        740        750        760        770        780 
TETNSLGFIL AFLYNGLLSI SAFACSYLGK DLPENYNEAK CVTFSLLFNF VSWIAFFTTA 

       790        800        810        820        830        840 
SVYDGKYLPA ANMMAGLSSL SSGFGGYFLP KCYVILCRPD LNSTEHFQAS IQDYTRRCGS 


T 

Q7RTX1 in FASTA format

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