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UniProtKB/Swiss-Prot entry Q7RM49


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CDC2H_PLAYO
Primary accession number Q7RM49
Secondary accession numbers None
Integrated into Swiss-Prot on April 18, 2006
Sequence was last modified on December 15, 2003 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 40)
Name and origin of the protein
Protein name Cell division control protein 2 homolog
Synonyms EC 2.7.11.22
EC 2.7.11.23
Gene name
Name: CRK2
ORFNames: PY02339
From
Plasmodium yoelii yoelii [TaxID: 73239] 
Taxonomy Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodium; Plasmodium (Vinckeia).
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=17XNL;
DOI=10.1038/nature01099; PubMed=12368865 [NCBI, ExPASy, EBI, Israel, Japan]
Carlton J.M., Angiuoli S.V., Suh B.B., Kooij T.W., Pertea M., Silva J.C., Ermolaeva M.D., Allen J.E., Selengut J.D., Koo H.L., Peterson J.D., Pop M., Kosack D.S., Shumway M.F., Bidwell S.L., Shallom S.J., van Aken S.E., Riedmuller S.B., Feldblyum T.V., Cho J.K., Quackenbush J., Sedegah M., Shoaibi A., Cummings L.M., Florens L., Yates J.R. III, Raine J.D., Sinden R.E., Harris M.A., Cunningham D.A., Preiser P.R., Bergman L.W., Vaidya A.B., van Lin L.H., Janse C.J., Waters A.P., Smith H.O., White O.R., Salzberg S.L., Venter J.C., Fraser C.M., Hoffman S.L., Gardner M.J., Carucci D.J.;
"Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii.";
Nature 419:512-519(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AABL01000639; EAA21777.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_730212.1; -.
3D structure databases
HSSP Q07785; 1OB3. [HSSP ENTRY / PDB]
SMR Q7RM49; 1-287.
ModBase Q7RM49.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004693; Molecular function: cyclin-dependent protein kinase activity (inferred from electronic annotation from EC).
GO:0008353; Molecular function: RNA polymerase subunit kinase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR002290; Ser_thr_pkinase.
Graphical view of domain structure.
Pfam PF00069; Pkinase; 1.
Pfam graphical view of domain structure.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00220; S_TKc; 1.
SMART graphical view of domain structure.
PROSITE PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q7RM49.
ProtoNet Q7RM49.
Genome annotation databases
GeneID 3807518; -.
KEGG pyo:PY02339; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Serine/threonine-protein kinase; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   289  289     Cell division control protein 2 homolog. PRO_0000232672
DOMAIN   4   285  282     Protein kinase. 
NP_BIND   10    18  9     ATP (By similarity). 
ACT_SITE   126   126        Proton acceptor (By similarity). 
BINDING   32    32        ATP (By similarity). 
MOD_RES   14    14        Phosphothreonine (By similarity). 
MOD_RES   15    15        Phosphotyrosine (By similarity). 
MOD_RES   159   159        Phosphothreonine; by CAK (By similarity). 
Sequence information
Length: 289 AA [This is the length of the unprocessed precursor] Molecular weight: 33121 Da [This is the MW of the unprocessed precursor] CRC64: 701FCFCEEA4F5CA3 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEKYHGLEKI GEGTYGVVYK AQNSDGESFA LKKIRLEKED EGIPSTVSIR EISILKELRH 

        70         80         90        100        110        120 
SNIVKLYDVI HAKKRLILVF EHLDQDLKKL IDVCDGGLES VTAKSFLLQL LNGIAYCHEH 

       130        140        150        160        170        180 
RVLHRDLKPQ NLLINREGEL KIADFGLARA FGIPARRYTH EVVTLWYRAP DILMGSKKYS 

       190        200        210        220        230        240 
TPIDIWSVGC IFAEMVNGRP LFPGVSETDQ LMRIFKILGT PNSQNWPDVF KLPKYDPNFP 

       250        260        270        280 
VYEPLPWETF IKGLDDTGID LLSKMLKLDP NQRITAKQAI EHPYFKETN 

Q7RM49 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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