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UniProtKB/Swiss-Prot entry Q7PR38


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ASSY_ANOGA
Primary accession number Q7PR38
Secondary accession numbers None
Integrated into Swiss-Prot on February 26, 2008
Sequence was last modified on January 9, 2007 (Sequence version 3)
Annotations were last modified on    November 4, 2008 (Entry version 39)
Name and origin of the protein
Protein name Argininosuccinate synthase
Synonyms EC 6.3.4.5
Citrulline--aspartate ligase
Gene name
ORFNames: AGAP003015
From
Anopheles gambiae (African malaria mosquito) [TaxID: 7165] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Anophelinae; Anopheles.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=PEST;
DOI=10.1126/science.1076181; PubMed=12364791 [NCBI, ExPASy, EBI, Israel, Japan]
Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
"The genome sequence of the malaria mosquito Anopheles gambiae.";
Science 298:129-149(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AAAB01008859; EAA07894.4; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_311863.3; -.
3D structure databases
ModBase Q7PR38.
Ontologies
GO
GO:0000050; Biological process: urea cycle (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001518; Arginosuc_synth.
IPR014729; Rossmann-like_a/b/a_fold.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.
PANTHER PTHR11587; Arginosuc_synth; 1.
Pfam PF00764; Arginosuc_synth; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00032; argG; 1.
PROSITE PS00564; ARGININOSUCCIN_SYN_1; 1.
PS00565; ARGININOSUCCIN_SYN_2; 1.
BLOCKS Q7PR38.
ProtoNet Q7PR38.
Genome annotation databases
GeneID 1272938; -.
KEGG aga:AgaP_AGAP003015; -.
VectorBase AGAP003015; Anopheles gambiae.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Arginine biosynthesis; ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Urea cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   424  424     Argininosuccinate synthase. PRO_0000321327
NP_BIND   9    17  9     ATP (By similarity). 
NP_BIND   114   122  9     ATP (By similarity). 
BINDING   35    35        ATP; via amide nitrogen and carbonyl oxygen (By similarity). 
BINDING   86    86        Citrulline (By similarity). 
BINDING   91    91        Citrulline (By similarity). 
BINDING   118   118        Aspartate (By similarity). 
BINDING   122   122        Aspartate (By similarity). 
BINDING   122   122        Citrulline (By similarity). 
BINDING   123   123        Aspartate (By similarity). 
BINDING   126   126        Citrulline (By similarity). 
BINDING   179   179        Citrulline (By similarity). 
BINDING   188   188        Citrulline (By similarity). 
BINDING   269   269        Citrulline (By similarity). 
BINDING   281   281        Citrulline (By similarity). 
Sequence information
Length: 424 AA [This is the length of the unprocessed precursor] Molecular weight: 47807 Da [This is the MW of the unprocessed precursor] CRC64: 133485FD4A9CC4B3 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSKEKVLLAY SGGLDTSCIL KWLLEQDYEV ICFMADVGQT EDFAAAREKA LKIGAADVVV 

        70         80         90        100        110        120 
KDMKDFFVEK FVWPAVQMGL IYEDRYLLGT SLARPCISKG LMDVAVQRGC SYISHGATGK 

       130        140        150        160        170        180 
GNDQIRFELS CYALSPTIRV IAPWRMETFC QRFQGRSDLL EYAKRSNIPV SATTKAPWSM 

       190        200        210        220        230        240 
DANIMHISYE SGILEDPSVA APEELYQLTQ SPTRAPDTPT VAEIVFKAGL PVRVTELVSG 

       250        260        270        280        290        300 
RTMERPVDIL AFLNKAGGEH GVGRIDIVEN RYIGLKSRGV YETPGVTVLH CAHRDLEIYC 

       310        320        330        340        350        360 
LDREVLRVKK YLADRMADYV YNGYWYAPEA EYVRKCILES QKHVSGKVVV EMFKGHVMVT 

       370        380        390        400        410        420 
SRESMHSLYN QELASMEVHG NFSPYSSTGF IEINAVRLRE HHRVFGTANM TKHFSRTESD 


MKLI 

Q7PR38 in FASTA format

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