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UniProtKB/Swiss-Prot entry Q7NZF7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SAHH_CHRVO
Primary accession number Q7NZF7
Secondary accession numbers None
Integrated into Swiss-Prot on May 24, 2004
Sequence was last modified on December 15, 2003 (Sequence version 1)
Annotations were last modified on    October 14, 2008 (Entry version 40)
Name and origin of the protein
Protein name Adenosylhomocysteinase
Synonyms EC 3.3.1.1
S-adenosyl-L-homocysteine hydrolase
AdoHcyase
Gene name
Name: ahcY
OrderedLocusNames: CV_0965
From
Chromobacterium violaceum [TaxID: 536] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae; Chromobacterium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 12472 / DSM 30191 / IFO 12614 / JCM 1249 / NCIB 9131;
DOI=10.1073/pnas.1832124100; PubMed=14500782 [NCBI, ExPASy, EBI, Israel, Japan]
Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T., Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R., Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F., Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S., Belo A., van den Berg C., Bogo M., Bonatto S., Bordignon J., Brigido M.M., Brito C.A., Brocchi M., Burity H.A., Camargo A.A., Cardoso D.D.P., Carneiro N.P., Carraro D.M., Carvalho C.M.B., Cascardo J.C.M., Cavada B.S., Chueire L.M.O., Creczynski-Pasa T.B., Cunha-Junior N.C., Fagundes N., Falcao C.L., Fantinatti F., Farias I.P., Felipe M.S.S., Ferrari L.P., Ferro J.A., Ferro M.I.T., Franco G.R., Freitas N.S.A., Furlan L.R., Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B., Grattapaglia D., Grisard E.C., Hanna E.S., Jardim S.N., Laurino J., Leoi L.C.T., Lima L.F.A., Loureiro M.F., Lyra M.C.C.P., Madeira H.M.F., Manfio G.P., Maranhao A.Q., Martins W.S., di Mauro S.M.Z., de Medeiros S.R.B., Meissner R.V., Moreira M.A.M., Nascimento F.F., Nicolas M.F., Oliveira J.G., Oliveira S.C., Paixao R.F.C., Parente J.A., Pedrosa F.O., Pena S.D.J., Pereira J.O., Pereira M., Pinto L.S.R.C., Pinto L.S., Porto J.I.R., Potrich D.P., Ramalho-Neto C.E., Reis A.M.M., Rigo L.U., Rondinelli E., Santos E.B.P., Santos F.R., Schneider M.P.C., Seuanez H.N., Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R., Simoes I.C., Simon D., Soares C.M.A., Soares R.B.A., Souza E.M., Souza K.R.L., Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R., Urmenyi T., Vettore A., Wassem R., Zaha A., Simpson A.J.G.;
"The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability.";
Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016825; AAQ58639.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_900635.1; -.
3D structure databases
ModBase Q7NZF7.
Enzyme and pathway databases
BioCyc CVIO243365:CV_0965-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004013; Molecular function: adenosylhomocysteinase activity (inferred from electronic annotation from HAMAP).
GO:0006730; Biological process: one-carbon compound metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00563; -; 1.
PBIL [Tree]
InterPro IPR000043; Ad_hcy_hydrolase.
IPR015878; Ado_hCys_hydrolase_NAD-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.1480; Ad_hcy_hydrolase; 1.
PANTHER PTHR23420; Ad_hcy_hydrolase; 1.
Pfam PF05221; AdoHcyase; 1.
PF00670; AdoHcyase_NAD; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001109; Ad_hcy_hydrolase; 1.
TIGRFAMs TIGR00936; ahcY; 1.
PROSITE PS00738; ADOHCYASE_1; 1.
PS00739; ADOHCYASE_2; 1.
BLOCKS Q7NZF7.
ProtoNet Q7NZF7.
Genome annotation databases
GeneID 2550940; -.
GenomeReviews AE016825_GR; CV_0965.
KEGG cvi:CV_0965; -.
NMPDR fig|243365.1.peg.965; -.
Phylogenomic databases
HOGENOM Q7NZF7; -.
Genome annotation databases
CMR Q7NZF7; CV_0965.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Hydrolase; NAD; One-carbon metabolism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   466  466     Adenosylhomocysteinase. PRO_0000116957
REGION   219   384  166     NAD binding (By similarity). 
BINDING   57    57        Substrate (By similarity). 
BINDING   132   132        Substrate (By similarity). 
BINDING   192   192        Substrate (By similarity). 
BINDING   222   222        Substrate (By similarity). 
BINDING   226   226        Substrate (By similarity). 
Sequence information
Length: 466 AA [This is the length of the unprocessed precursor] Molecular weight: 51456 Da [This is the MW of the unprocessed precursor] CRC64: 5301EBA3D2D5675D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MADFSDFHVA DIALAGWGRK ELNIAETEMP GLMATRDEYH AAQPLRGARI AGSLHMTVQT 

        70         80         90        100        110        120 
AVLIETLTAL GAEVRWASCN IFSTQDHAAA AIAAAGIPVF AFKGESLDEY WEFSHKIFEW 

       130        140        150        160        170        180 
PEGQPANMIL DDGGDATLLL MLGSKAEKDI GVIAHPTNEE ETALFASIKR HLAIDPHWYS 

       190        200        210        220        230        240 
KRLEHIQGVT EETTTGVHRL YQLEKDGHLP FPAINVNDSV TKSKFDNLYG CRESLVDGIK 

       250        260        270        280        290        300 
RATDVMVAGK VAVVLGYGDV GKGCAQSLRG LGATVWVTEI DPICALQAAM EGYRVVRMDE 

       310        320        330        340        350        360 
VADQADIFVT ATGNVGVITH EHMKKMRNNA IICNIGHFDS EIEVASLRQY QWENIKPQVD 

       370        380        390        400        410        420 
HIIFPDGKRV ILLAEGRLVN LGCATGHPSF VMSNSFTNQV LAQIELFANG HKYEKKVYVL 

       430        440        450        460 
PKHLDEKVAR LHLARIGARL TELSDQQAAY ISVPKQGPYK PDHYRY 

Q7NZF7 in FASTA format

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