NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=PCC 7421;
DOI=10.1093/dnares/10.4.137; PubMed=14621292 [NCBI, ExPASy, EBI, Israel, Japan]
Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S.;
"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids.";
DNA Res. 10:137-145(2003).

Comments

FUNCTION: The glycine cleavage system catalyzes the degradation of glycine (By similarity).
CATALYTIC ACTIVITY: [Protein]-S⁸-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH₃.
SUBUNIT: The glycine cleavage system is composed of four proteins: P, T, L and H (By similarity).
SIMILARITY: Belongs to the gcvT family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000045; BAC91471.1; ALT_INIT; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_926476.1; -.

3D structure databases

ModBase

Q7NFJ5.

Enzyme and pathway databases

BioCyc

GVIO251221:GLR3530-MON; -.

Ontologies

GO:0004047;	Molecular function: aminomethyltransferase activity (inferred from electronic annotation from HAMAP).
GO:0008483;	Molecular function: transaminase activity (inferred from electronic annotation from UniProtKB-KW).
GO:0019464;	Biological process: glycine decarboxylation via glycine cleavage system (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00259; -; 1.
PBIL [Tree]

InterPro

IPR013977; GCV_T_C.
IPR006222; GCV_T_N.
IPR006223; GcvT.
Graphical view of domain structure.

Pfam

PF01571; GCV_T; 1.
PF08669; GCV_T_C; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF006487; GcvT; 1.

TIGR00528; gcvT; 1.

Genome annotation databases

GeneID

2601934; -.

GenomeReviews

BA000045_GR; glr3530.

KEGG

gvi:glr3530; -.

NMPDR

fig|251221.1.peg.3530; -.

Phylogenomic databases

HOGENOM

Q7NFJ5; -.

Genome annotation databases

CMR

Q7NFJ5; glr3530.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Aminotransferase; Complete proteome; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 359`	`359`		`Aminomethyltransferase.`	`PRO_0000122560`

Sequence information

Length: 359 AA [This is the length of the unprocessed precursor]

Molecular weight: 39569 Da [This is the MW of the unprocessed precursor]

CRC64: 7857B9A1F3FDDD61 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSDLKRTPLC AQHLQLGARL VPFGGWEMPL QYSTLTREHR AVRTAVGLFD ISHMGKYTLS 

        70         80         90        100        110        120 
GPDVLAQIQR LVPSDLARLQ PGQAQYTVLL NEQAGIIDDL IFYCRSPEHW VVIVNGATND 

       130        140        150        160        170        180 
KDRRWLAEHL QGVHFDDLTG THTLLALQGP AAVETLQPLV DIDLARLGRF EHAQVSLAGK 

       190        200        210        220        230        240 
PAFLARTGYT GEDGFEIMSL EPEGIALWQS LTAAGVPPCG LGARDTLRLE AAMHLYGQDM 

       250        260        270        280        290        300 
DESTTPLEAS LGWVIDWDKP DYFGREILLA QKAQGTERRL VGLTVEGRQI ARHGYGLFDG 

       310        320        330        340        350 
EQQVGVVTSG TLTPTVDRPI ALAYVGKPFA PIGSRLEVDI RGRRAMATVV KRPFYRRAL

Q7NFJ5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools