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UniProtKB/Swiss-Prot entry Q7N6I6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HIS2_PHOLL
Primary accession number Q7N6I6
Secondary accession numbers None
Integrated into Swiss-Prot on March 15, 2004
Sequence was last modified on December 15, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 34)
Name and origin of the protein
Protein name Histidine biosynthesis bifunctional protein hisIE
Synonyms None
Includes Phosphoribosyl-AMP cyclohydrolase
     (PRA-CH)
     (EC 3.5.4.19)
Phosphoribosyl-ATP pyrophosphatase
     (PRA-PH)
     (EC 3.6.1.31)
Gene name
Name: hisI
Synonyms: hisIE
OrderedLocusNames: plu1564
From
Photorhabdus luminescens subsp. laumondii [TaxID: 141679] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Photorhabdus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=TT01;
DOI=10.1038/nbt886; PubMed=14528314 [NCBI, ExPASy, EBI, Israel, Japan]
Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A., Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F., Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C., Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M., Glaser P., Boemare N., Danchin A., Kunst F.;
"The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens.";
Nat. Biotechnol. 21:1307-1313(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX571864; CAE13857.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_928855.1; -.
3D structure databases
ModBase Q7N6I6.
Enzyme and pathway databases
BioCyc PLUM243265:PLU1564-MON; -.
Organism-specific databases
PhotoList plu1564; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004635; Molecular function: phosphoribosyl-AMP cyclohydrolase activity (inferred from electronic annotation from HAMAP).
GO:0004636; Molecular function: phosphoribosyl-ATP diphosphatase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01019; -; 1.
PBIL [Tree]
InterPro IPR002496; PRA_CycOHase.
IPR008179; PRib-ATP_pyrophosphohydrolase.
Graphical view of domain structure.
Pfam PF01502; PRA-CH; 1.
PF01503; PRA-PH; 1.
Pfam graphical view of domain structure.
ProDom PD002610; PRA_cyclohydro; 1.
PD002611; Pra_PH/CH; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR03188; histidine_hisI; 1.
BLOCKS Q7N6I6.
ProtoNet Q7N6I6.
Genome annotation databases
GeneID 2801559; -.
GenomeReviews BX470251_GR; plu1564.
KEGG plu:plu1564; -.
NMPDR fig|243265.1.peg.1479; -.
Phylogenomic databases
HOGENOM Q7N6I6; -.
Genome annotation databases
CMR Q7N6I6; plu1564.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Cytoplasm; Histidine biosynthesis; Hydrolase; Multifunctional enzyme.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   201  201     Histidine biosynthesis bifunctional protein hisIE. PRO_0000136421
REGION   1   114  114     Phosphoribosyl-AMP cyclohydrolase. 
REGION   115   201  87     Phosphoribosyl-ATP pyrophosphohydrolase. 
Sequence information
Length: 201 AA [This is the length of the unprocessed precursor] Molecular weight: 22615 Da [This is the MW of the unprocessed precursor] CRC64: D6F71C699D6674BF [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLTAQQIEKL DWEKVAYMMP VIVQHAISGD VLMMGYMNKE ALNITISSGK ITFFSRSKQR 

        70         80         90        100        110        120 
LWTKGESSGH FLNLVNIYPD CDNDTLLALA DPIGPTCHFG THSCFAPAQT EWGFLYQLEK 

       130        140        150        160        170        180 
LLASRKTADP DHSYTAKLYA SGTKRIAQKV GEEGLETALA AAVNNREELT NEAADLMYHL 

       190        200 
MVLLQDQELD LSCVIRRLRE R
Q7N6I6 in FASTA format

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