ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q7L576


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name CYFP1_HUMAN
Primary accession number Q7L576
Secondary accession numbers Q14467 Q5IED0 Q6ZSX1 Q9BSD9 Q9BVC7
Integrated into Swiss-Prot on March 6, 2007
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 35)
Name and origin of the protein
Protein name Cytoplasmic FMR1-interacting protein 1
Synonyms Specifically Rac1-associated protein 1
Sra-1
p140sra-1
Gene name
Name: CYFIP1
Synonyms: KIAA0068
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
Jiang Y.-H., Beaudet A.L.;
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Bone marrow;
DOI=10.1093/dnares/1.5.223; PubMed=7584044 [NCBI, ExPASy, EBI, Israel, Japan]
Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.;
"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.";
DNA Res. 1:223-229(1994).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Brain;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain, and Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PROTEIN SEQUENCE OF 50-58; 111-130; 151-163; 366-377; 441-448; 505-515; 564-573; 754-760; 815-826; 867-877; 1054-1076; 1211-1224 AND 1228-1240, AND MASS SPECTROMETRY.
TISSUE=B-cell lymphoma, and Hepatoma;
Bienvenut W.V., Claeys D., Boldt K., von Kriegsheim A.F., Kolch W.;
Submitted (JUL-2007) to UniProtKB.
[6]
FUNCTION.
DOI=10.1074/jbc.273.1.291; PubMed=9417078 [NCBI, ExPASy, EBI, Israel, Japan]
Kobayashi K., Kuroda S., Fukata M., Nakamura T., Nagase T., Nomura N., Matsuura Y., Yoshida-Kubomura N., Iwamatsu A., Kaibuchi K.;
"p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase.";
J. Biol. Chem. 273:291-295(1998).
[7]
FUNCTION, AND INTERACTION WITH DPYSL2.
DOI=10.1128/MCB.25.22.9920-9935.2005; PubMed=16260607 [NCBI, ExPASy, EBI, Israel, Japan]
Kawano Y., Yoshimura T., Tsuboi D., Kawabata S., Kaneko-Kawano T., Shirataki H., Takenawa T., Kaibuchi K.;
"CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.";
Mol. Cell. Biol. 25:9920-9935(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY763577; AAW51476.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY763578; AAW51477.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY763579; AAW51478.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY763580; AAW51479.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D38549; BAA07552.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK127094; BAC86825.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC001306; AAH01306.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC005097; AAH05097.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001028200.1; -.
NP_055423.1; -.
UniGene Hs.26704
3D structure databases
ModBase Q7L576.
Protein-protein interaction databases
IntAct Q7L576; -.
PTM databases
PhosphoSite Q7L576; -.
Organism-specific databases
HGNC HGNC:13759; CYFIP1.
GenAtlas CYFIP1.
MIM 606322; gene. [NCBI / EBI]
PharmGKB PA38367; -.
GeneCards Q7L576.
HUGE KIAA0068.
Gene expression databases
ArrayExpress Q7L576; -.
CleanEx HS_CYFIP1; -.
Ontologies
GO
GO:0030027; Cellular component: lamellipodium (inferred from sequence or structural similarity from UniProtKB).
GO:0048471; Cellular component: perinuclear region of cytoplasm (inferred from sequence or structural similarity from UniProtKB).
GO:0001726; Cellular component: ruffle (inferred from sequence or structural similarity from UniProtKB).
GO:0019717; Cellular component: synaptosome (inferred from sequence or structural similarity from UniProtKB).
GO:0051015; Molecular function: actin filament binding (inferred from sequence or structural similarity from UniProtKB).
GO:0048365; Molecular function: Rac GTPase binding (inferred from sequence or structural similarity from UniProtKB).
GO:0048675; Biological process: axon extension (inferred from mutant phenotype from UniProtKB).
GO:0030032; Biological process: lamellipodium biogenesis (inferred from sequence or structural similarity from UniProtKB).
GO:0031529; Biological process: ruffle organization and biogenesis (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR008081; Cytoplasmic_FMR1-int.
IPR016536; Cytoplasmic_FMR1-int_sub.
Graphical view of domain structure.
PANTHER PTHR12195; FragX_IP; 1.
Pfam PF05994; FragX_IP; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF008153; FMR1_interacting; 1.
PRINTS PR01698; CYTOFMRPINTP.
BLOCKS Q7L576.
Genome annotation databases
Ensembl ENSG00000068793; Homo sapiens. [Contig view]
GeneID 23191; -.
KEGG hsa:23191; -.
Phylogenomic databases
HOVERGEN Q7L576; -.
Other
SOURCE CYFIP1; Homo sapiens.
ProtoNet Q7L576.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Actin-binding; Alternative splicing; Cell junction; Cell projection; Cell shape; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Neurogenesis; Synapse; Synaptosome.
Features
SEVIEWER logo Feature table viewer
KeyFrom    To Length Description FTId
CHAIN   1   1253  1253     Cytoplasmic FMR1-interacting protein 1. PRO_0000279706
VAR_SEQ   1    806        Missing (in isoform 3). VSP_052345
VAR_SEQ   1    431        Missing (in isoform 2). VSP_052346
VAR_SEQ   432    557        AEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESV FNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVL QAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRA VGPSST -> MAESLGSAELLRQLKSLGMERLLHAVNTFLRQSCTYLPLL TFGGKTSFVSLDVYGTEANCSATSCSFPKAAATWPRRQAP GPLGELVRGPPDQGVAEQSFSHGLFEFGITNVPCIFSPPQ MFPWII (in isoform 2). VSP_052347
CONFLICT   583    583        S -> N (in Ref. 1; AAW51478 and 3; BAC86825). 
CONFLICT   820    820        G -> S (in Ref. 1; AAW51478, 3; BAC86825 and 4; AAH01306). 
CONFLICT   898    898        Y -> H (in Ref. 1; AAW51478 and 3; BAC86825). 
CONFLICT   930    930        M -> R (in Ref. 1; AAW51478 and 3; BAC86825). 
CONFLICT   1176   1176        V -> A (in Ref. 1; AAW51479). 
Sequence information
Length: 1253 AA [This is the length of the unprocessed precursor] Molecular weight: 145182 Da [This is the MW of the unprocessed precursor] CRC64: D8F45E13207BEF16 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAAQVTLEDA LSNVDLLEEL PLPDQQPCIE PPPSSLLYQP NFNTNFEDRN AFVTGIARYI 

        70         80         90        100        110        120 
EQATVHSSMN EMLEEGQEYA VMLYTWRSCS RAIPQVKCNE QPNRVEIYEK TVEVLEPEVT 

       130        140        150        160        170        180 
KLMNFMYFQR NAIERFCGEV RRLCHAERRK DFVSEAYLIT LGKFINMFAV LDELKNMKCS 

       190        200        210        220        230        240 
VKNDHSAYKR AAQFLRKMAD PQSIQESQNL SMFLANHNKI TQSLQQQLEV ISGYEELLAD 

       250        260        270        280        290        300 
IVNLCVDYYE NRMYLTPSEK HMLLKVMGFG LYLMDGSVSN IYKLDAKKRI NLSKIDKYFK 

       310        320        330        340        350        360 
QLQVVPLFGD MQIELARYIK TSAHYEENKS RWTCTSSGSS PQYNICEQMI QIREDHMRFI 

       370        380        390        400        410        420 
SELARYSNSE VVTGSGRQEA QKTDAEYRKL FDLALQGLQL LSQWSAHVME VYSWKLVHPT 

       430        440        450        460        470        480 
DKYSNKDCPD SAEEYERATR YNYTSEEKFA LVEVIAMIKG LQVLMGRMES VFNHAIRHTV 

       490        500        510        520        530        540 
YAALQDFSQV TLREPLRQAI KKKKNVIQSV LQAIRKTVCD WETGHEPFND PALRGEKDPK 

       550        560        570        580        590        600 
SGFDIKVPRR AVGPSSTQLY MVRTMLESLI ADKSGSKKTL RSSLEGPTIL DIEKFHRESF 

       610        620        630        640        650        660 
FYTHLINFSE TLQQCCDLSQ LWFREFFLEL TMGRRIQFPI EMSMPWILTD HILETKEASM 

       670        680        690        700        710        720 
MEYVLYSLDL YNDSAHYALT RFNKQFLYDE IEAEVNLCFD QFVYKLADQI FAYYKVMAGS 

       730        740        750        760        770        780 
LLLDKRLRSE CKNQGATIHL PPSNRYETLL KQRHVQLLGR SIDLNRLITQ RVSAAMYKSL 

       790        800        810        820        830        840 
ELAIGRFESE DLTSIVELDG LLEINRMTHK LLSRYLTLDG FDAMFREANH NVSAPYGRIT 

       850        860        870        880        890        900 
LHVFWELNYD FLPNYCYNGS TNRFVRTVLP FSQEFQRDKQ PNAQPQYLHG SKALNLAYSS 

       910        920        930        940        950        960 
IYGSYRNFVG PPHFQVICRL LGYQGIAVVM EELLKVVKSL LQGTILQYVK TLMEVMPKIC 

       970        980        990       1000       1010       1020 
RLPRHEYGSP GILEFFHHQL KDIVEYAELK TVCFQNLREV GNAILFCLLI EQSLSLEEVC 

      1030       1040       1050       1060       1070       1080 
DLLHAAPFQN ILPRVHVKEG ERLDAKMKRL ESKYAPLHLV PLIERLGTPQ QIAIAREGDL 

      1090       1100       1110       1120       1130       1140 
LTKERLCCGL SMFEVILTRI RSFLDDPIWR GPLPSNGVMH VDECVEFHRL WSAMQFVYCI 

      1150       1160       1170       1180       1190       1200 
PVGTHEFTVE QCFGDGLHWA GCMIIVLLGQ QRRFAVLDFC YHLLKVQKHD GKDEIIKNVP 

      1210       1220       1230       1240       1250 
LKKMVERIRK FQILNDEIIT ILDKYLKSGD GEGTPVEHVR CFQPPIHQSL ASS 

Q7L576 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!