[1]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=7897267 [NCBI, ExPASy, EBI, Israel, Japan] Takeda K.; "Expression of serine/threonine kinase receptors during ectopic bone formation induced by bone morphogenetic protein (BMP)."; Kokubyo Gakkai Zasshi 61:512-526(1994).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=Wistar; TISSUE=Dental pulp; DOI=10.1006/bbrc.1994.2445; PubMed=7945360 [NCBI, ExPASy, EBI, Israel, Japan] Takeda K., Oida S., Ichijo H., Iimura T., Maruoka Y., Amagasa T., Sasaki S.; "Molecular cloning of rat bone morphogenetic protein (BMP) type IA receptor and its expression during ectopic bone formation induced by BMP."; Biochem. Biophys. Res. Commun. 204:203-209(1994).
[3]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=Wistar; TISSUE=Brain; Ikeda T., Takahashi H.; "Expression pattern of bone morphogenetic protein 4 receptor in embryo and adult rat."; Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4 (By similarity).
CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
COFACTOR: Magnesium or manganese (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
SIMILARITY: Contains 1 GS domain.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

S75359; AAB33865.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
D38082; BAA07275.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
D17667; BAA04549.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

JC2387; JC2387.

NP_110476.1; -.

3D structure databases

HSSP

P36897; 1B6C. [HSSP ENTRY / PDB]

SMR

Q78EA7; 55-146.

ModBase

Q78EA7.

Organism-specific databases

RGD

70989; Bmpr1a.

Gene expression databases

ArrayExpress

Q78EA7; -.

Family and domain databases

InterPro

IPR000333; Activin_II_recpt.
IPR000472; Activin_rcpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR003605; TGF_beta_rcpt_GS.
Graphical view of domain structure.

Pfam

PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
Pfam graphical view of domain structure.

PRINTS

PR00653; ACTIVIN2R.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00467; GS; 1.
SMART graphical view of domain structure.

PROSITE

PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q78EA7.

Genome annotation databases

Ensembl

ENSRNOG00000010814; Rattus norvegicus. [Contig view]

GeneID

81507; -.

KEGG

rno:81507; -.

Phylogenomic databases

HOVERGEN

Q78EA7; -.

Other

ProtoNet

Q78EA7.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 23`	`23`	`Potential.`
`CHAIN`	`24 532`	`509`	`Bone morphogenetic protein receptor type-1A.`	`PRO_0000254907`
`TOPO_DOM`	`24 152`	`129`	`Extracellular (Potential).`
`TRANSMEM`	`153 176`	`24`	`Potential.`
`TOPO_DOM`	`177 532`	`356`	`Cytoplasmic (Potential).`
`DOMAIN`	`204 233`	`30`	`GS.`
`DOMAIN`	`234 525`	`292`	`Protein kinase.`
`NP_BIND`	`240 248`	`9`	`ATP (By similarity).`
`ACT_SITE`	`362 362`		`Proton acceptor (By similarity).`
`BINDING`	`261 261`		`ATP (By similarity).`
`MOD_RES`	`215 215`		`Phosphoserine (By similarity).`
`MOD_RES`	`216 216`		`Phosphoserine (By similarity).`
`MOD_RES`	`218 218`		`Phosphoserine (By similarity).`
`MOD_RES`	`220 220`		`Phosphoserine (By similarity).`
`CARBOHYD`	`73 73`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`61 82`		`By similarity.`
`DISULFID`	`63 67`		`By similarity.`
`DISULFID`	`76 100`		`By similarity.`
`DISULFID`	`110 124`		`By similarity.`
`DISULFID`	`125 130`		`By similarity.`

Sequence information

Length: 532 AA [This is the length of the unprocessed precursor]

Molecular weight: 59994 Da [This is the MW of the unprocessed precursor]

CRC64: 14ED4C03E2540A0C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDVD QKKPENGVTL APEDTLPFLK 

        70         80         90        100        110        120 
CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC MKYEGSDFQC KDSPKAQLRR 

       130        140        150        160        170        180 
TIECCRTNLC NQYLQPTLPP VVIGPFFDGS VRWLAVLISM AVCIVAMIVF SSCFCYKHYC 

       190        200        210        220        230        240 
KSISSRGRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 

       250        260        270        280        290        300 
GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 

       310        320        330        340        350        360 
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 

       370        380        390        400        410        420 
RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT RVGTRRYMAP EVLDESLSKN 

       430        440        450        460        470        480 
HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 

       490        500        510        520        530 
PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI

Q78EA7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools