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UniProtKB/Swiss-Prot entry Q75JR3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDHC_DICDI
Primary accession number Q75JR3
Secondary accession number Q559Q1
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 30)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP] cytoplasmic
Synonyms EC 1.1.1.42
IDH 1
Cytosolic NADP-isocitrate dehydrogenase 1
Oxalosuccinate decarboxylase 1
NADP(+)-specific ICDH 1
IDP 1
Gene name
Name: idhC
ORFNames: DDB_0231401
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature00847; PubMed=12097910 [NCBI, ExPASy, EBI, Israel, Japan]
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.;
"Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
Nature 418:79-85(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
[3]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
DOI=10.1074/mcp.M600113-MCP200; PubMed=16926386 [NCBI, ExPASy, EBI, Israel, Japan]
Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T.;
"Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake.";
Mol. Cell. Proteomics 5:2228-2243(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AC116963; AAS45361.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AAFI02000008; EAL71256.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_645283.1; -.
3D structure databases
ModBase Q75JR3.
Organism-specific databases
dictyBase DDB0231401; idhC.
Family and domain databases
InterPro IPR004790; IsoCit_DHase_NADP-dep_euk.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11822; IDH_NADP_euk; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000108; IDH_NADP; 1.
TIGRFAMs TIGR00127; nadp_idh_euk; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q75JR3.
Genome annotation databases
GeneID 3396432; -.
KEGG ddi:DDB_0231401; -.
Other
ProtoNet Q75JR3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   412  412     Isocitrate dehydrogenase [NADP] cytoplasmic. PRO_0000328190
NP_BIND   76    78  3     NADP (By similarity). 
NP_BIND   309   314  6     NADP (By similarity). 
REGION   95   101  7     Substrate binding (By similarity). 
METAL   253   253        Magnesium or manganese (By similarity). 
METAL   276   276        Magnesium or manganese (By similarity). 
BINDING   78    78        Substrate (By similarity). 
BINDING   83    83        NADP (By similarity). 
BINDING   110   110        Substrate (By similarity). 
BINDING   133   133        Substrate (By similarity). 
BINDING   261   261        NADP (By similarity). 
BINDING   327   327        NADP; via amide nitrogen and carbonyl oxygen (By similarity). 
SITE   140   140  1     Critical for catalysis (By similarity). 
SITE   213   213  1     Critical for catalysis (By similarity). 
Sequence information
Length: 412 AA [This is the length of the unprocessed precursor] Molecular weight: 46370 Da [This is the MW of the unprocessed precursor] CRC64: 129878D79347E4A7 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVEKIIVSNP VANLLGDEQT RVIWDLIEKK LIFPFLDLKV ETYDLGIEYR DKTNDQVTID 

        70         80         90        100        110        120 
AANAIKRLKV GIKCATITPD EARVTEFGLK EMWKSPNGTI RNTLGGTLFR EPIVCKNVPR 

       130        140        150        160        170        180 
LVTCWNKSIV IGRHAFGDQY RATDFVVKGA GKLELTYTPA DGSAPQKFQV FDFPSDGGVA 

       190        200        210        220        230        240 
LGMYNTDASI KEFAYACFNF SLDKKWPLYL STKNTILKRY DGRFKDIFQE IYEREYKVKF 

       250        260        270        280        290        300 
DTAGIWYEHR LIDDMVAYAM KSEGGFVWAC KNYDGDVQSD AVAQGYGSLG LMTSVLLSAD 

       310        320        330        340        350        360 
SLVAEASHGT VTRHFREHQK GRETSTNSIA SIFAWTRGLE YRAKLDNNDK LLKFCHALEA 

       370        380        390        400        410 
SCIDAVESGF MTKDLAICVK GSVENVKRTD YLNTEEYINK VAELLVSKLT AL 

Q75JR3 in FASTA format

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