NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 10895 / NRRL Y-1056 / CBS 109.51;
DOI=10.1126/science.1095781; PubMed=15001715 [NCBI, ExPASy, EBI, Israel, Japan]
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.;
"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome.";
Science 304:304-307(2004).

Comments

FUNCTION: Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes (By similarity).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE016816; AAS51174.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_983350.1; -.

3D structure databases

ModBase

Q75CH3.

Organism-specific databases

AGD

ACL054W; -.

Family and domain databases

InterPro

IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR002290; Ser_thr_pkinase.
Graphical view of domain structure.

Pfam

PF00069; Pkinase; 1.
Pfam graphical view of domain structure.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00220; S_TKc; 1.
SMART graphical view of domain structure.

PROSITE

PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q75CH3.

Genome annotation databases

4619475; -.

fig|33169.1.peg.995; -.

Phylogenomic databases

HOGENOM

Q75CH3; -.

Other

ProtoNet

Q75CH3.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Autophagy; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Protein transport; Serine/threonine-protein kinase; Transferase; Transport.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 972`	`972`	`Serine/threonine-protein kinase ATG1.`	`PRO_0000085638`
`DOMAIN`	`18 319`	`302`	`Protein kinase.`
`NP_BIND`	`24 32`	`9`	`ATP (By similarity).`
`ACT_SITE`	`166 166`		`Proton acceptor (By similarity).`
`BINDING`	`48 48`		`ATP (By similarity).`

Sequence information

Length: 972 AA [This is the length of the unprocessed precursor]

Molecular weight: 109057 Da [This is the MW of the unprocessed precursor]

CRC64: F2EFF374025DDFAE [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNNVKSGGRP VAIVAERYVV EKEIGRGSFA VVYKGHLADS SAGNVAIKAV SRSKLRNKKL 

        70         80         90        100        110        120 
LENLEIEIAI LKKIKHPHIV GLLECERTGT DFYLMMEYCA LGDLTFFIKK RRSLMDKHPL 

       130        140        150        160        170        180 
VRTLFEKYPP PSEHHNGLNR VLVVNYLQQL SSALKFLRSK NLVHRDIKPQ NLLLSTPLVD 

       190        200        210        220        230        240 
YNDPAEFHAR GFVGIYNLPI LKIADFGFAR FLPNTSLAET LCGSPLYMAP EILNYQKYNA 

       250        260        270        280        290        300 
KADLWSVGTV LYEMCCGKPP FKASNHLELF QKIKKANDVI QFPKHAALES AMVDLICGLL 

       310        320        330        340        350        360 
TFEPAKRMGF TEFFSNGLVN EDLSPYEVES EPDLETKSKN VAESNMFISE YLPTAERNKR 

       370        380        390        400        410        420 
ASPIRLGDSC TLRGPCESPQ GADPYPQDNT QSDQHEHLHA DYSFQVEMGQ DGQQADGEEK 

       430        440        450        460        470        480 
RKLYNNQEER SNEERQFGQV SNGRNQEDQL LLHQGRGQIP CEQNRQALQS HSHVAAKQIP 

       490        500        510        520        530        540 
DKDSKSSVSC QKHAASAPTK NDHRTTRLKE KTKCSYSDLL LEKEYVVVEK KSVEVNALAD 

       550        560        570        580        590        600 
EFAQAGSGAP AIRLPDQHHN DASQALQMAR HSSTSVSAAN TAKQTLLRRN SRTLSSSGAS 

       610        620        630        640        650        660 
TSRRPSLVDR RLSITSLGAT NALSKALGMA SLRLFGNSHQ QSSNGSSTFK QNPNVTSLLS 

       670        680        690        700        710        720 
PQTFQDMTEN AVLSADHQWD NSRQADVLHD DSIMKALENL TAKVYAIYSF AEVKFSQIIP 

       730        740        750        760        770        780 
LPPSSTQDPY THKRMSNGSC AIDDEEDDIE HSPGAETYRK NSSGANANTG NYNFSLDTIH 

       790        800        810        820        830        840 
EMNLNDLPPN DLYILCTEAI VLYMKSLSLL AYAMHLTSKW WHESADKICP LKLNLLVQWI 

       850        860        870        880        890        900 
RERFNECLEK AEFLRMKTQS IQLHNGNQLS ASTMVSEPVF VEKLIYDRAL DISKTAAKME 

       910        920        930        940        950        960 
MQGEYLEGCE VAYSTSLWML EALLDDVSDE DNYNDDNLGH TGVLDKSDKE VIKRYIDSIA 

       970 
NRLKALRRKL SR

Q75CH3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools