NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 10895 / NRRL Y-1056 / CBS 109.51;
DOI=10.1126/science.1095781; PubMed=15001715 [NCBI, ExPASy, EBI, Israel, Japan]
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.;
"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome.";
Science 304:304-307(2004).

Comments

FUNCTION: Responsible for methylating the 5'-cap structure of mRNAs (By similarity).
CATALYTIC ACTIVITY: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m₇G(5')pppR-RNA.
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the mRNA cap methyltransferase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE016819; AAS53346.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_985522.1; -.

3D structure databases

ModBase

Q754U7.

Organism-specific databases

AGD

AFL026W; -.

Family and domain databases

InterPro

IPR016899; mRNA_G-N7_MeTrfase.
IPR004971; Pox_MCEL.
Graphical view of domain structure.

Pfam

PF03291; Pox_MCEL; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF028762; ABD1; 1.

BLOCKS

Q754U7.

Genome annotation databases

4621755; -.

fig|33169.1.peg.3167; -.

Phylogenomic databases

HOGENOM

Q754U7; -.

Other

ProtoNet

Q754U7.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Methyltransferase; mRNA capping; mRNA processing; Nucleus; RNA-binding; S-adenosyl-L-methionine; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 430`	`430`		`mRNA cap guanine-N7 methyltransferase.`	`PRO_0000303900`

Sequence information

Length: 430 AA [This is the length of the unprocessed precursor]

Molecular weight: 50419 Da [This is the MW of the unprocessed precursor]

CRC64: 8FFCE1F2A42613DD [This is a checksum on the sequence]

        10         20         30         40         50         60 
MALRPEKPVW MSQEQYDRQY GKLEEPKPPR EESKPGDQAK PSAEPKSGSE EKTEGSSSST 

        70         80         90        100        110        120 
GQGEERPHFK IQKRRHQNYD LEERKKKQQL NKLREEQLKQ HDIEMAANKV VNVDQIVREH 

       130        140        150        160        170        180 
YNERTFHAKR YNRNYSPIIK LRNFNNAIKY MLIDKYTRPR DVVLELGCGK GGDLRKYGAC 

       190        200        210        220        230        240 
EISQFIGIDI SNESIREAQR RYLNMRDLDY QVILITGDCF GESLGVAVQP FPECRFPCDV 

       250        260        270        280        290        300 
VSTQFCLHYA FETEEKARRA ILNVSKSLKV GGFFFGTIPD AEFIRYKLNK FSKEVERPSW 

       310        320        330        340        350        360 
GNSIYKVVFA NNSYQLNDYE FETPYGNMYT YWLEDAIDNV PEYVIPFETL RNLCDEYGME 

       370        380        390        400        410        420 
LEMQKPFNKF FVEEIPQWMN KFSPRLREGL QRSDGKYGVE GDEKEAASYF YTVFAFRKVK 

       430 
DYVENAPAHA

Q754U7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools