ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q74N29

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name DP2L_NANEQ
Primary accession number Q74N29
Secondary accession numbers None
Integrated into Swiss-Prot on July 10, 2007
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 25)
Name and origin of the protein
Protein name DNA polymerase II large subunit
Synonyms Pol II
EC 2.7.7.7
Gene name
Name: polC
OrderedLocusNames: NEQ420
From
Nanoarchaeum equitans [TaxID: 160232] [HAMAP proteome]
Taxonomy Archaea; Nanoarchaeota; Nanoarchaeum.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Kin4-M;
DOI=10.1073/pnas.1735403100; PubMed=14566062 [NCBI, ExPASy, EBI, Israel, Japan]
Waters E., Hohn M.J., Ahel I., Graham D.E., Adams M.D., Barnstead M., Beeson K.Y., Bibbs L., Bolanos R., Keller M., Kretz K., Lin X., Mathur E., Ni J., Podar M., Richardson T., Sutton G.G., Simon M., Soell D., Stetter K.O., Short J.M., Noorderwier M.;
"The genome of Nanoarchaeum equitans: insights into early archaeal evolution and derived parasitism.";
Proc. Natl. Acad. Sci. U.S.A. 100:12984-12988(2003).
Comments
  • FUNCTION: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
  • CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
  • CATALYTIC ACTIVITY: Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.
  • SUBUNIT: Heterodimer of a large subunit and a small subunit (By similarity).
  • SIMILARITY: Belongs to the archaeal DNA polymerase II family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE017199; AAR39264.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_963703.1; -.
3D structure databases
ModBase Q74N29.
Ontologies
GO
GO:0008408; Molecular function: 3'-5' exonuclease activity (inferred from electronic annotation from HAMAP).
GO:0003677; Molecular function: DNA binding (inferred from electronic annotation from HAMAP).
GO:0003887; Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0000738; Biological process: DNA catabolic process, exonucleolytic (inferred from electronic annotation from HAMAP).
GO:0006261; Biological process: DNA-dependent DNA replication (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00324; -; 1.
PBIL [Tree]
InterPro IPR004475; PolC_DP2.
IPR016033; PolC_DP2_N.
Graphical view of domain structure.
Pfam PF03833; PolC_DP2; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF016275; PolC_DP2; 1.
TIGRFAMs TIGR00354; polC; 1.
BLOCKS Q74N29.
Genome annotation databases
GeneID 2732644; -.
GenomeReviews AE017199_GR; NEQ420.
KEGG neq:NEQ420; -.
Phylogenomic databases
HOGENOM Q74N29; -.
Genome annotation databases
CMR Q74N29; NEQ420.
Other
ProtoNet Q74N29.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; DNA replication; DNA-binding; DNA-directed DNA polymerase; Exonuclease; Hydrolase; Multifunctional enzyme; Nuclease; Nucleotidyltransferase; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   1243  1243     DNA polymerase II large subunit. PRO_0000294697
Sequence information
Length: 1243 AA [This is the length of the unprocessed precursor] Molecular weight: 142593 Da [This is the MW of the unprocessed precursor] CRC64: A48088166C1CF516 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MVYYDILAKE LEKLYEIAEK ARAQGYDPKD IVEIPLANNM GERVAHLISA IHEQLDVKKT 

        70         80         90        100        110        120 
AELILELEKQ YGFLDWRVGL KLIDYALEGK LIPYDDILKR IDLGVRLALG YITMGVVSAP 

       130        140        150        160        170        180 
LEGLVELRIK KRKDGKPYLA LYYAGPIRGA GGTAAAVSVL FADYARKKAG LYEYDPTKEE 

       190        200        210        220        230        240 
IERYKIEIDS YHNKVARLQY KPSDEEIEFL VKHIPVEING DPTSDKEVPS YKNLERVETN 

       250        260        270        280        290        300 
RIRGGMCLVI AEGIAQKAKK IYGKITEWGK EFGLEHWEFL GEYLKLQKEI QAKLAAESGG 

       310        320        330        340        350        360 
EIEGKEIKRK ITLFLDEIKK EEITVKYPTP AGKYLQEITA GRPIFSLPMA IGGFRLRYGR 

       370        380        390        400        410        420 
SFATGFATSG IHPATMFLTY GFLAIGTQMR GERPKKSTIV TPVTSLHPPI VKLKDGTVKK 

       430        440        450        460        470        480 
VHSVVEAIKI ANDVEEILFL GDILTAFGDW LNEKANLVPS PYVEEWWIQE FDRAAMKKTD 

       490        500        510        520        530        540 
YKIEFDVMKP RKLFKIEGLE NLSQYLGIPK DRLEEIIRKP FSRKPTIDEA ITISEKLGIP 

       550        560        570        580        590        600 
LHPEYTPFWV HITKEELIKL IEELRKAKIQ NNKIYFHESQ KELKAILEKL FIEHFREGEY 

       610        620        630        640        650        660 
FYINESMTKS LLYQLDNLNL EKAKKEFDNA IDALDLVNRL SPIEIRDVAG VYVGFRAGRP 

       670        680        690        700        710        720 
EKAKMREMTG RPHGLFPVGE EGGKMRNVIE AYNKGYVKAE FALYYCNHCK RYTIYRKCEV 

       730        740        750        760        770        780 
CGNKTKEVYV CKEIINRLKT SLFKQYKDWK KVEEEIASHL WAEAVTHSKN NCREPKRYSL 

       790        800        810        820        830        840 
IKLNIKHYVD RAVQKLKLFN IPKLVKGVRG TSNKDHIVER LEKAFLRSVS DVYVNKDGTI 

       850        860        870        880        890        900 
RYDGTQIPLT HFRPKDLIGV TIEKLKELGY THDIYGNPLE REDQILQLKP QDIILPYGIL 

       910        920        930        940        950        960 
VKSRLNKNKI VRTDAAEAFK KVANFVDEEL KRLYNLEPYY NIEKAEDLIG KIVFGIAPHT 

       970        980        990       1000       1010       1020 
SAAVVGRIIG FTPIQGIIAH PIWHAGQRRN CDGDETAVML GLDALINFSR EYLPDKRGAR 

      1030       1040       1050       1060       1070       1080 
TMDAPLVLTL KLELKAVDDE VHDMDIVYNY PLEFYYETLK GSPAKDVKKQ CGILTLGDFL 

      1090       1100       1110       1120       1130       1140 
KEEDISKIPI GFTHPTKSIR LGNKVSLYKR LKTMQQKTEW QLKLAERIRA VDENIVAEIV 

      1150       1160       1170       1180       1190       1200 
IEKHFMPDIK GNLRGFSSQV FRCTKCDTTY DRVPLSGKCP KCGGNIVFTV HEGTIKKYLP 

      1210       1220       1230       1240 
TSLYLARKYK IKKFTKQSLF LLDRRIKQIF GGEKKSLADF INS
Q74N29 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ch flag SIB Switzerland Mirror sites: Australia Brazil Canada China Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!