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UniProtKB/Swiss-Prot entry Q74J32

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_LACJO
Primary accession number Q74J32
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 34)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: LJ_1278
From
Lactobacillus johnsonii [TaxID: 33959] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NCC 533;
DOI=10.1073/pnas.0307327101; PubMed=14983040 [NCBI, ExPASy, EBI, Israel, Japan]
Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C., Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R., Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.;
"The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533.";
Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE017198; AAS09099.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_965133.1; -.
3D structure databases
ModBase Q74J32.
Enzyme and pathway databases
BioCyc LJOH257314:LJ_1278-MON; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
ProDom PD000518; DHOase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; FALSE_NEG.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS Q74J32.
Genome annotation databases
GeneID 2743536; -.
GenomeReviews AE017198_GR; LJ_1278.
KEGG ljo:LJ1278; -.
NMPDR fig|257314.1.peg.1119; -.
Phylogenomic databases
HOGENOM Q74J32; -.
Genome annotation databases
CMR Q74J32; LJ_1278.
Other
ProtoNet Q74J32.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   425  425     Dihydroorotase. PRO_1000024090
METAL   56    56        Zinc 1 (By similarity). 
METAL   58    58        Zinc 1 (By similarity). 
METAL   138   138        Zinc 1 (via carbamate group) (By similarity). 
METAL   138   138        Zinc 2 (via carbamate group) (By similarity). 
METAL   175   175        Zinc 2 (By similarity). 
METAL   228   228        Zinc 2 (By similarity). 
METAL   301   301        Zinc 1 (By similarity). 
MOD_RES   138   138        N6-carboxylysine (By similarity). 
Sequence information
Length: 425 AA [This is the length of the unprocessed precursor] Molecular weight: 46053 Da [This is the MW of the unprocessed precursor] CRC64: 99C2F52414311027 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTTVIKNGTV YQNGHLIKAD VLIDGQKIKA IGTDLEGEEI IDASGMIVSP GLVDVHVHYR 

        70         80         90        100        110        120 
DPGQTYKEDI KTGSQAAARG GFTTVGAMPN VTPVPNTAEL MDKMVRENQK KGLVHILQYG 

       130        140        150        160        170        180 
PVTNDETTDI IPDYAALKKA GAFALSNDGH GVQSAQTMYL AMQKAKENNL IIAAHAQDDS 

       190        200        210        220        230        240 
LFNKGIVNEG IAAEKLDLPP VTELAETTQI ARDLLLAQKT GVHYHICHVS TKTSVELVRL 

       250        260        270        280        290        300 
AKARGIKVTC EVAPHHILLT DSDIPEDNAY FKMNPPLRSK EDQVALLVGL LDGTIDLIAT 

       310        320        330        340        350        360 
DHAPHAKAEK QGGMRGAAFG ITGSETAFST LYTRFVKEEK VFTLEQLLSL LTDKPATVFG 

       370        380        390        400        410        420 
IENAGLLAPG ENADIAIFDI EHQREIKEDD FKSKGVNTPF TGHKVYGETV MTFVDGKVVY 


QRGTK
Q74J32 in FASTA format

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