NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-968 / K-10;
DOI=10.1073/pnas.0505662102; PubMed=16116077 [NCBI, ExPASy, EBI, Israel, Japan]
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.;
"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis.";
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).

Comments

FUNCTION: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBCELLULAR LOCATION: Cytoplasm (Probable).
SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE016958; AAS06026.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_962410.1; -.

3D structure databases

ModBase

Q73U92.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0045020;	Biological process: error-prone DNA repair (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01902; -; 1.
PBIL [Tree]

InterPro

IPR011708; DNA_pol3_alpha.
IPR004365; NA_bd_OB_tRNA-helicase.
IPR004013; PHP_C.
IPR003141; PHP_N.
IPR004805; PolC_alpha.
Graphical view of domain structure.

Pfam

PF07733; DNA_pol3_alpha; 1.
PF02811; PHP; 1.
PF01336; tRNA_anti; 1.
Pfam graphical view of domain structure.

SMART

SM00481; POLIIIAc; 1.
SMART graphical view of domain structure.

TIGRFAMs

TIGR00594; polc; 1.

BLOCKS

Q73U92.

Genome annotation databases

GeneID

2721197; -.

GenomeReviews

AE016958_GR; MAP_3476c.

KEGG

mpa:MAP3476c; -.

NMPDR

fig|262316.1.peg.3476; -.

Phylogenomic databases

HOGENOM

Q73U92; -.

Genome annotation databases

CMR

Q73U92; MAP_3476c.

Other

ProtoNet

Q73U92.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1093`	`1093`		`Error-prone DNA polymerase.`	`PRO_0000103384`

Sequence information

Length: 1093 AA [This is the length of the unprocessed precursor]

Molecular weight: 118223 Da [This is the MW of the unprocessed precursor]

CRC64: 9AB2F22EFD7BFF35 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGWFNGPPSW AEMERVLDSK PRRAGESAAP EPDGPLSRGR ATYRPPDEGR AARSSVPYAE 

        70         80         90        100        110        120 
LHAHSAFSFL DGASTPEEMV EEAARLDLRA LALTDHDGLY GAVRFAEAAA ELDVRTVFGA 

       130        140        150        160        170        180 
ELSLGPSART EAPDPPGPHL LVLARGPEGY RRLSRQLAAA HLAGGEKGKP RYDLDALTEA 

       190        200        210        220        230        240 
AGGHWHILTG CRKGHVRQAL SDGGPDAAAR ALADLVDRFG AARVSIELTR HGQPLDDERN 

       250        260        270        280        290        300 
AALAALAPRF GVGVVATTGA HFAGPSRRRL AMAMGAIRAR ESLDSAAGWL APLGGSHLRS 

       310        320        330        340        350        360 
GAEMARLFAW RPQAVTAAAE LGEQCAFGLA LIAPRLPPFD VPDGHTEDSW LRQLTMTGAR 

       370        380        390        400        410        420 
DRYGSPEHAP RAYAQIEHEL KVIAQLQFPG YFLVVHDIAR FCRENNILCQ GRGSAANSAV 

       430        440        450        460        470        480 
CYALGVTAVD PVANELLFER FLSPARDGPP DIDMDIESDQ REKVIQYVYD RYGRDYAAQV 

       490        500        510        520        530        540 
ANVITYRGKI AVRDMARALG YSQGQQDAWS KQISSWSGPA DSPDVEGIPP QVIDLANQVR 

       550        560        570        580        590        600 
NLPRHLGIHS GGMVICDRPI ADVCPVEWAR MENRSVLQWD KDDCAAIGLV KFDLLGLGML 

       610        620        630        640        650        660 
SALHYAIDLV AEHKGIEVDL ARLDLSEPAV YEMLARADSV GVFQVESRAQ MATLPRLKPR 

       670        680        690        700        710        720 
VFYDLVVEVA LIRPGPIQGG SVHPYIRRRN GVDPVLYDHP SMEPALRKTL GVPLFQEQLM 

       730        740        750        760        770        780 
QLAVDCAGFS AAEADQLRRA MGSKRSTERM RRLRSRFYDG MRALHGAPDE VIDRTYEKLE 

       790        800        810        820        830        840 
AFANFGFPES HALSFASLVF YSSWFKLHHP AAFCAALLRA QPMGFYSPQS LVADARRHGV 

       850        860        870        880        890        900 
TVHGPDVNAS LAHATLENAG TEVRLGLGAV RHIGDDLAEK LVQERKANGP FTSLLDLTAR 

       910        920        930        940        950        960 
LQLSVQQTEA LATAGAFGCF GMSRREALWA AGAAATQRPD RLPGVGSSSH IPALPGMSEL 

       970        980        990       1000       1010       1020 
ELAAADVWAT GISPDSYPTQ FLRDDLDAMG VVPAARLGSV PDGDRVLIAG AVTHRQRPGT 

      1030       1040       1050       1060       1070       1080 
AQGVTFLNLE DETGMVNVLC TPGVWARHRK LANTAPALLV RGQVQNASGA ITVVAERLGR 

      1090 
ITLAVGSRSR DFR

Q73U92 in FASTA format

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View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools