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UniProtKB/Swiss-Prot entry Q6ZN44


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UNC5A_HUMAN
Primary accession number Q6ZN44
Secondary accession numbers Q8TF26 Q96GP4
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on October 11, 2004 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 59)
Name and origin of the protein
Protein name Netrin receptor UNC5A [Precursor]
Synonyms Protein unc-5 homolog A
Unc-5 homolog 1
Gene name
Name: UNC5A
Synonyms: KIAA1976, UNC5H1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Brain;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 302-842.
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 624-728.
TISSUE=Brain;
DOI=10.1093/dnares/8.6.319; PubMed=11853319 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T., Kikuno R., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.";
DNA Res. 8:319-327(2001).
[4]
INDUCTION.
DOI=10.1038/ncb943; PubMed=12598906 [NCBI, ExPASy, EBI, Israel, Japan]
Tanikawa C., Matsuda K., Fukuda S., Nakamura Y., Arakawa H.;
"p53RDL1 regulates of p53-dependent apoptosis.";
Nat. Cell Biol. 5:216-223(2003).
[5]
DOWN-REGULATION IN CANCER.
DOI=10.1073/pnas.0738063100; PubMed=12655055 [NCBI, ExPASy, EBI, Israel, Japan]
Thiebault K., Mazelin L., Pays L., Llambi F., Joly M.-O., Scoazec J.-Y., Saurin J.-C., Romeo G., Mehlen P.;
"The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.";
Proc. Natl. Acad. Sci. U.S.A. 100:4173-4178(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK131380; BAD18531.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC009333; AAH09333.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC033727; -; NOT_ANNOTATED_CDS; mRNA.[EMBL / GenBank / DDBJ]
AB075856; BAB85562.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00176345; -.
IPI00418573; -.
IPI00470692; -.
RefSeq NP_588610.2; -.
UniGene Hs.33191
3D structure databases
ModBase Q6ZN44.
Organism-specific databases
GeneCards GC05P176170; -.
H-InvDB HIX0005448; -.
HGNC HGNC:12567; UNC5A.
GenAtlas UNC5A.
MIM 607869; gene. [NCBI / EBI]
PharmGKB PA37204; -.
HUGE KIAA1976.
Gene expression databases
ArrayExpress Q6ZN44; -.
Bgee Q6ZN44; -.
CleanEx HS_UNC5A; -.
GermOnline ENSG00000113763; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005515; Molecular function: protein binding (inferred from electronic annotation from InterPro).
GO:0004872; Molecular function: receptor activity (inferred from electronic annotation from UniProtKB-KW).
GO:0006915; Biological process: apoptosis (inferred from electronic annotation from UniProtKB-KW).
GO:0007275; Biological process: multicellular organismal development (inferred from electronic annotation from UniProtKB-KW).
GO:0007165; Biological process: signal transduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000488; Death.
IPR011029; DEATH-like.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR000884; Thrombospondin_1_rpt.
IPR000906; ZU5.
Graphical view of domain structure.
Gene3D G3DSA:1.10.533.10; DEATH_like; 1.
G3DSA:2.60.40.10; Ig-like_fold; 1.
Pfam PF00531; Death; 1.
PF07679; I-set; 1.
PF00090; TSP_1; 1.
PF00791; ZU5; 1.
Pfam graphical view of domain structure.
SMART SM00005; DEATH; 1.
SM00409; IG; 1.
SM00209; TSP1; 1.
SM00218; ZU5; 1.
SMART graphical view of domain structure.
PROSITE PS50017; DEATH_DOMAIN; FALSE_NEG.
PS50835; IG_LIKE; 1.
PS50092; TSP1; 1.
PS51145; ZU5; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q6ZN44; -.
Genome annotation databases
Ensembl ENSG00000113763; Homo sapiens. [Contig view]
GeneID 90249; -.
KEGG hsa:90249; -.
Phylogenomic databases
HOGENOM Q6ZN44; -.
HOVERGEN Q6ZN44; -.
Other
NextBio 76616; -.
SOURCE UNC5A; Homo sapiens.
ProtoNet Q6ZN44.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Apoptosis; Cell membrane; Developmental protein; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    25  25     Potential. 
CHAIN   26   842  817     Netrin receptor UNC5A. PRO_0000036068
TOPO_DOM   1   306  306     Extracellular (Potential). 
TRANSMEM   307   327  21     Potential. 
TOPO_DOM   328   842  515     Cytoplasmic (Potential). 
DOMAIN   44   141  98     Ig-like. 
DOMAIN   155   234  80     Ig-like C2-type. 
DOMAIN   242   294  53     TSP type-1. 
DOMAIN   439   545  107     ZU5. 
DOMAIN   761   841  81     Death. 
REGION   605   623  19     Interaction with DCC (By similarity). 
SITE   340   341  2     Cleavage; by caspase-3 (By similarity). 
CARBOHYD   107   107        N-linked (GlcNAc...) (Potential). 
CARBOHYD   218   218        N-linked (GlcNAc...) (Potential). 
CARBOHYD   287   287        N-linked (GlcNAc...) (Potential). 
DISULFID   65   124        By similarity. 
DISULFID   170   221        By similarity. 
VAR_SEQ   1    97        MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANP DLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGE WVRQVDHVIERSTDGSN -> MAGTSERSLISSISQPKAIECFEVKKKAFLTHGRYHGSGA TPPKTKDPKPETFCGQT (in isoform 3). VSP_011693
VAR_SEQ   296   301        TASGPE -> SESSLP (in isoform 2). VSP_011694
VAR_SEQ   302   842        Missing (in isoform 2). VSP_011695
Sequence information
Length: 842 AA [This is the length of the unprocessed precursor] Molecular weight: 92959 Da [This is the MW of the unprocessed precursor] CRC64: 3DFADCF973131849 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAVRPGLWPA LLGIVLAAWL RGSGAQQSAT VANPVPGANP DLLPHFLVEP EDVYIVKNKP 

        70         80         90        100        110        120 
VLLVCKAVPA TQIFFKCNGE WVRQVDHVIE RSTDGSNGLP TMEVRINVSR QQVEKVFGLE 

       130        140        150        160        170        180 
EYWCQCVAWS SSGTTKSQKA YIRIAYLRKN FEQEPLAKEV SLEQGIVLPC RPPEGIPPAE 

       190        200        210        220        230        240 
VEWLRNEDLV DPSLDPNVYI TREHSLVVRQ ARLADTANYT CVAKNIVARR RSASAAVIVY 

       250        260        270        280        290        300 
VDGSWSPWSK WSACGLDCTH WRSRECSDPA PRNGGEECQG TDLDTRNCTS DLCVHTASGP 

       310        320        330        340        350        360 
EDVALYVGLI AVAVCLVLLL LVLILVYCRK KEGLDSDVAD SSILTSGFQP VSIKPSKADN 

       370        380        390        400        410        420 
PHLLTIQPDL STTTTTYQGS LCPRQDGPSP KFQLTNGHLL SPLGGGRHTL HHSSPTSEAE 

       430        440        450        460        470        480 
EFVSRLSTQN YFRSLPRGTS NMTYGTFNFL GGRLMIPNTG ISLLIPPDAI PRGKIYEIYL 

       490        500        510        520        530        540 
TLHKPEDVRL PLAGCQTLLS PIVSCGPPGV LLTRPVILAM DHCGEPSPDS WSLRLKKQSC 

       550        560        570        580        590        600 
EGSWEDVLHL GEEAPSHLYY CQLEASACYV FTEQLGRFAL VGEALSVAAA KRLKLLLFAP 

       610        620        630        640        650        660 
VACTSLEYNI RVYCLHDTHD ALKEVVQLEK QLGGQLIQEP RVLHFKDSYH NLRLSIHDVP 

       670        680        690        700        710        720 
SSLWKSKLLV SYQEIPFYHI WNGTQRYLHC TFTLERVSPS TSDLACKLWV WQVEGDGQSF 

       730        740        750        760        770        780 
SINFNITKDT RFAELLALES EAGVPALVGP SAFKIPFLIR QKIISSLDPP CRRGADWRTL 

       790        800        810        820        830        840 
AQKLHLDSHL SFFASKPSPT AMILNLWEAR HFPNGNLSQL AAAVAGLGQP DAGLFTVSEA 


EC 

Q6ZN44 in FASTA format

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