[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=cv. Nipponbare; The international rice genome sequencing project (IRGSP) consortium; "Oryza sativa nipponbare chromosome 8 genomic DNA sequence."; Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=cv. Nipponbare; DOI=10.1126/science.1081288; PubMed=12869764 [NCBI, ExPASy, EBI, Israel, Japan] The rice full-length cDNA consortium; "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."; Science 301:376-379(2003).

Comments

FUNCTION: mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity).
CATALYTIC ACTIVITY: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m₇G(5')pppR-RNA.
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the mRNA cap methyltransferase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AP004692; BAD17036.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AP008214; BAF23050.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AK063927; -; NOT_ANNOTATED_CDS; mRNA.	[EMBL / GenBank / DDBJ]

RefSeq

NP_001061136.1; -.

UniGene

Os.21877

3D structure databases

ModBase

Q6Z9U7.

Organism-specific databases

Gramene

Q6Z9U7; -.

Family and domain databases

InterPro

IPR016899; mRNA_G-N7_MeTrfase.
IPR004971; Pox_MCEL.
Graphical view of domain structure.

Pfam

PF03291; Pox_MCEL; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF028762; ABD1; 1.

BLOCKS

Q6Z9U7.

Genome annotation databases

GeneID

4344818; -.

KEGG

osa:4344818; -.

Other

ProtoNet

Q6Z9U7.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Methyltransferase; mRNA capping; mRNA processing; Nucleus; RNA-binding; S-adenosyl-L-methionine; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 369`	`369`	`mRNA cap guanine-N7 methyltransferase 1.`	`PRO_0000248332`
`REGION`	`70 71`	`2`	`mRNA cap binding (By similarity).`
`BINDING`	`74 74`		`S-adenosyl-L-methionine (By similarity).`
`BINDING`	`92 92`		`S-adenosyl-L-methionine; via carbonyl oxygen (By similarity).`
`BINDING`	`95 95`		`mRNA cap (By similarity).`
`BINDING`	`101 101`		`mRNA cap (By similarity).`
`BINDING`	`114 114`		`S-adenosyl-L-methionine (By similarity).`
`BINDING`	`126 126`		`mRNA cap (By similarity).`
`BINDING`	`149 149`		`S-adenosyl-L-methionine (By similarity).`
`BINDING`	`171 171`		`S-adenosyl-L-methionine; via carbonyl oxygen (By similarity).`
`BINDING`	`175 175`		`mRNA cap (By similarity).`
`BINDING`	`263 263`		`mRNA cap (By similarity).`
`BINDING`	`332 332`		`mRNA cap (By similarity).`

Sequence information

Length: 369 AA [This is the length of the unprocessed precursor]

Molecular weight: 42040 Da [This is the MW of the unprocessed precursor]

CRC64: C18AD9B1B380AE62 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNKRPRDEPS SSFASAPKRQ YGAGGGGYGG HGYSEERSSA RRVADHYSAR SNQTLEEREN 

        70         80         90        100        110        120 
SPIIHLKKLN NWIKSVLIQL YAHPGDCVLD LACGKGGDLI KWDKAKVGYY VGVDIAEGSI 

       130        140        150        160        170        180 
KDCMTRYNGD TDQQRRKKFS FPARLICADC YEARLDEHLY EDAPFDICSC QFALHYSWST 

       190        200        210        220        230        240 
EARARQALAN VSALLRPGGV FIGTMPDANV IIKRLRETDG MEFGNGVYWI SFGEEYAEKK 

       250        260        270        280        290        300 
FPASRPFGIK YKFHLEDAVD CPEWVVPFHL FKLLAEEYDL ELVLTKNFHE FVHEYLQKPE 

       310        320        330        340        350        360 
FAELMRRLGA LGDGRQDQST LSQDEWEVAY LYLAFVLRKR GQPPSQRRAN NANRGKMFLT 


ENDIDFLGV

Q6Z9U7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools