[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, RNA-BINDING, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION. TISSUE=Fibroblast; DOI=10.1016/S0378-1119(99)00515-6; PubMed=10675610 [NCBI, ExPASy, EBI, Israel, Japan] Penkov D., Ni R., Else C., Pinol-Roma S., Ramirez F., Tanaka S.; "Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins."; Gene 243:27-36(2000).
[2]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3). Lee Y.-H., Tokraks S., Bogardus C., Permana P.A.; "Cloning and characterization of novel alternatively spliced transcripts of RBMS3: skeletal muscle mRNA level correlates with whole body insulin resistance."; Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Binds poly(A) and poly(U) oligoribonucleotides.
SUBCELLULAR LOCATION: Cytoplasm.

ALTERNATIVE PRODUCTS: 4 named isoforms [FASTA] produced by alternative splicing.

Name	1
Synonyms	DD23-L
Isoform ID	Q6XE24-1
This is the isoform sequence displayed in this entry.

Name	2
Isoform ID	Q6XE24-2
Features which should be applied to build the isoform sequence: VSP_022928, VSP_022930, VSP_022931.

Name	3
Synonyms	DD23-S
Isoform ID	Q6XE24-3
Features which should be applied to build the isoform sequence: VSP_022927, VSP_022929.

Name	4
Isoform ID	Q6XE24-4
Features which should be applied to build the isoform sequence: VSP_022930, VSP_022931.

TISSUE SPECIFICITY: Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
SEQUENCE CAUTION:
- Sequence=AAC63910.1; Type=Frameshift; Positions=1;

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF023259; AAC63910.1; ALT_FRAME; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY236871; AAP75555.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY236872; AAP75556.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC117315; AAI17316.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00298424; -.
IPI00456051; -.
IPI00472404; -.
IPI00827856; -.

RefSeq

NP_001003792.1; -.
NP_001003793.1; -.
NP_055298.2; -.

UniGene

Hs.696468

3D structure databases

HSSP

P19339; 1B7F. [HSSP ENTRY / PDB]

SMR

Q6XE24; 61-134, 120-223.

ModBase

Q6XE24.

PTM databases

PhosphoSite

Q6XE24; -.

Organism-specific databases

GC03P029298; -.

HGNC:13427; RBMS3.

605786; gene. [NCBI / EBI]

PharmGKB

PA34276; -.

Gene expression databases

ArrayExpress

Q6XE24; -.

Bgee

Q6XE24; -.

CleanEx

HS_RBMS3; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-SubCell).
GO:0000166;	Molecular function: nucleotide binding (inferred from electronic annotation from InterPro).
GO:0003723;	Molecular function: RNA binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR012677; a_b_plait_nuc_bd.
IPR002343; Hud_Sxl_RNA.
IPR000504; RRM_RNP1.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.70.330; a_b_plait_nuc_bd; 2.

Pfam

PF00076; RRM_1; 2.
Pfam graphical view of domain structure.

PRINTS

PR00961; HUDSXLRNA.

SMART

SM00360; RRM; 2.
SMART graphical view of domain structure.

PROSITE

PS50102; RRM; 2.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

Q6XE24; -.

Genome annotation databases

Ensembl

ENSG00000144642; Homo sapiens. [Contig view]

GeneID

27303; -.

KEGG

hsa:27303; -.

Phylogenomic databases

HOVERGEN

Q6XE24; -.

OMA

Q6XE24; XAGMALT.

Other

50293; -.

RBMS3; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Cytoplasm; Repeat; RNA-binding.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 437`	`437`	`RNA-binding motif, single-stranded-interacting protein 3.`	`PRO_0000274906`
`DOMAIN`	`61 134`	`74`	`RRM 1.`
`DOMAIN`	`140 225`	`86`	`RRM 2.`
`VAR_SEQ`	`26 26`		`Missing (in isoform 3).`	`VSP_022927`
`VAR_SEQ`	`247 247`		`G -> GEVLRGRTVPRQNR (in isoform 2).`	`VSP_022928`
`VAR_SEQ`	`297 313`		`Missing (in isoform 3).`	`VSP_022929`
`VAR_SEQ`	`351 366`		`Missing (in isoform 2 and isoform 4).`	`VSP_022930`
`VAR_SEQ`	`437 437`		`Missing (in isoform 2 and isoform 4).`	`VSP_022931`
`CONFLICT`	`93 93`		`I -> L (in Ref. 2; AAP75556).`
`CONFLICT`	`165 165`		`H -> P (in Ref. 2; AAP75556).`

Sequence information

Length: 437 AA [This is the length of the unprocessed precursor]

Molecular weight: 47840 Da [This is the MW of the unprocessed precursor]

CRC64: 7EFC2ECFE24E323C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGKRLDQPQM YPQYTYYYPH YLQTKQSYAP APHPMAPPSP STNSSSNNSS NNSSGEQLSK 

        70         80         90        100        110        120 
TNLYIRGLPP GTTDQDLIKL CQPYGKIVST KAILDKNTNQ CKGYGFVDFD SPAAAQKAVA 

       130        140        150        160        170        180 
SLKANGVQAQ MAKQQEQDPT NLYISNLPIS MDEQELENML KPFGHVISTR ILRDANGVSR 

       190        200        210        220        230        240 
GVGFARMEST EKCEVVIQHF NGKYLKTPPG IPAPSEPLLC KFADGGQKKR QNQSKYTQNG 

       250        260        270        280        290        300 
RPWPREGEAG MALTYDPTAA IQNGFYSSPY SIATNRMIPQ TSITPFIAAS PVSTYQVQST 

       310        320        330        340        350        360 
SWMPHPPYVM QPTGAVITPT MDHPMSMQPA NMMGPLTQQM NHLSLGTTGT IQSQDRIMIL 

       370        380        390        400        410        420 
HQLLCQYMTA AAPMQGTYIP QYTPVPPTAV SIEGVVADTS PQTVAPSSQD TSGQQQQIAV 

       430 
DTSNEHAPAY SYQQSKP

Q6XE24 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools