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UniProtKB/Swiss-Prot entry Q6SJ96

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TBPL2_HUMAN
Primary accession number Q6SJ96
Secondary accession number Q17RU8
Integrated into Swiss-Prot on February 5, 2008
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 42)
Name and origin of the protein
Protein name TATA box-binding protein-like protein 2
Synonyms TBP-like protein 2
TATA box-binding protein-related factor 3
TBP-related factor 3
Gene name
Name: TBPL2
Synonyms: TBP2, TRF3
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
DOI=10.1073/pnas.2036440100; PubMed=14634207 [NCBI, ExPASy, EBI, Israel, Japan]
Persengiev S.P., Zhu X., Dixit B.L., Maston G.A., Kittler E.L.W., Green M.R.;
"TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed.";
Proc. Natl. Acad. Sci. U.S.A. 100:14887-14891(2003).
[2]
 NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
DOI=10.1089/dna.2006.0527; PubMed=17570761 [NCBI, ExPASy, EBI, Israel, Japan]
Di Pietro C., Ragusa M., Duro L., Guglielmino M.R., Barbagallo D., Carnemolla A., Lagana A., Buffa P., Angelica R., Rinaldi A., Calafato M.S., Milicia I., Caserta C., Giugno R., Pulvirenti A., Giunta V., Rapisarda A., Di Pietro V., Grillo A., Messina A., Ferro A., Grzeschik K.H., Purrello M.;
"Genomics, evolution, and expression of TBPL2, a member of the TBP family.";
DNA Cell Biol. 26:369-385(2007).
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-31.
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
  • FUNCTION: Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity).
  • SUBUNIT: Interacts with TAF3 (By similarity).
  • SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Present in the cytoplasm during cytokenesis.
  • TISSUE SPECIFICITY: Ubiquitously expressed in all tissues examined with highest levels in heart, lung, ovary, spleen and testes.
  • SIMILARITY: Belongs to the TBP family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY457923; AAR24281.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
DQ448593; ABD93323.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC117159; AAI17160.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC117185; AAI17186.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00791135; -.
RefSeq NP_950248.1; -.
UniGene Hs.528278
3D structure databases
HSSP P62001; 1AIS. [HSSP ENTRY / PDB]
SMR Q6SJ96; 197-374.
ModBase Q6SJ96.
Organism-specific databases
GeneCards GC14M054950; -.
HGNC HGNC:19841; TBPL2.
GenAtlas TBPL2.
MIM 608964; gene. [NCBI / EBI]
Gene expression databases
ArrayExpress Q6SJ96; -.
CleanEx HS_TBPL2; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from UniProtKB).
GO:0005669; Cellular component: transcription factor TFIID complex (inferred from electronic annotation from InterPro).
GO:0003702; Molecular function: RNA polymerase II transcription factor activity (inferred from electronic annotation from InterPro).
GO:0007275; Biological process: multicellular organismal development (inferred from electronic annotation from UniProtKB-KW).
GO:0006367; Biological process: transcription initiation from RNA polymerase II promoter (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR012295; b_Adaptin_TBP_C.
IPR000814; TBP.
Graphical view of domain structure.
Gene3D G3DSA:3.30.310.10; b_Adaptin_TBP_C; 2.
PANTHER PTHR10126; TBP; 1.
Pfam PF00352; TBP; 2.
Pfam graphical view of domain structure.
PRINTS PR00686; TIFACTORIID.
PROSITE PS00351; TFIID; 2.
Proteomic databases
PRIDE Q6SJ96; -.
Genome annotation databases
Ensembl ENSG00000182521; Homo sapiens. [Contig view]
GeneID 387332; -.
KEGG hsa:387332; -.
NMPDR fig|9606.3.peg.9635; -.
Phylogenomic databases
HOVERGEN Q6SJ96; -.
OMA Q6SJ96; LYLDQCA.
Other
NextBio 101297; -.
SOURCE TBPL2; Homo sapiens.
ProtoNet Q6SJ96.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Developmental protein; DNA-binding; Nucleus; Polymorphism; Transcription; Transcription regulation.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   375  375     TATA box-binding protein-like protein 2. PRO_0000318118
COMPBIAS   22    26  5     Poly-Pro. 
VARIANT   31    31  1     R -> P (in dbSNP:rs8019270 [NCBI]). VAR_038692 
Sequence information
Length: 375 AA [This is the length of the unprocessed precursor] Molecular weight: 41524 Da [This is the MW of the unprocessed precursor] CRC64: E55539A49FE76704 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MASAPWPERV PRLLAPRLPS YPPPPPTVGL RSMEQEETYL ELYLDQCAAQ DGLAPPRSPL 

        70         80         90        100        110        120 
FSPVVPYDMY ILNASNPDTA FNSNPEVKET SGDFSSVDLS FLPDEVTQEN KDQPVISKHE 

       130        140        150        160        170        180 
TEENSESQSP QSRLPSPSEQ DVGLGLNSSS LSNSHSQLHP GDTDSVQPSP EKPNSDSLSL 

       190        200        210        220        230        240 
ASITPMTPMT PISECCGIVP QLQNIVSTVN LACKLDLKKI ALHAKNAEYN PKRFAAVIMR 

       250        260        270        280        290        300 
IREPRTTALI FSSGKMVCTG AKSEEQSRLA ARKYARVVQK LGFPARFLDF KIQNMVGSCD 

       310        320        330        340        350        360 
VRFPIRLEGL VLTHQQFSSY EPELFPGLIY RMVKPRIVLL IFVSGKVVLT GAKERSEIYE 

       370 
AFENIYPILK GFKKA
Q6SJ96 in FASTA format

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