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UniProtKB/Swiss-Prot entry Q6QA33

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DH12B_DANRE
Primary accession number Q6QA33
Secondary accession number Q6PBR0
Integrated into Swiss-Prot on September 5, 2006
Sequence was last modified on September 5, 2006 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 32)
Name and origin of the protein
Protein name Estradiol 17-beta-dehydrogenase 12-B
Synonyms EC 1.1.1.62
17-beta-hydroxysteroid dehydrogenase 12-B
17-beta-HSD 12-B
zfHSD17B12B
zf3.3
Gene name
Name: hsd17b12b
ORFNames: zgc:73289
From
Danio rerio (Zebrafish) (Brachydanio rerio) [TaxID: 7955] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
DOI=10.1016/j.mce.2003.11.010; PubMed=15026171 [NCBI, ExPASy, EBI, Israel, Japan]
Mindnich R., Deluca D., Adamski J.;
"Identification and characterization of 17 beta-hydroxysteroid dehydrogenases in the zebrafish, Danio rerio.";
Mol. Cell. Endocrinol. 215:19-30(2004).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY551080; AAS58450.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC059617; AAH59617.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_955907.1; -.
UniGene Dr.20571
3D structure databases
ModBase Q6QA33.
Organism-specific databases
ZFIN ZDB-GENE-030131-1346; hsd17b12b.
Gene expression databases
ArrayExpress Q6QA33; -.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004303; Molecular function: estradiol 17-beta-dehydrogenase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR19410; ADH_short_C2; 1.
Pfam PF00106; adh_short; 1.
Pfam graphical view of domain structure.
PRINTS PR00081; GDHRDH.
PR00080; SDRFAMILY.
PROSITE PS00061; ADH_SHORT; FALSE_NEG.
BLOCKS Q6QA33.
Genome annotation databases
Ensembl ENSDARG00000035872; Danio rerio. [Contig view]
GeneID 322626; -.
KEGG dre:322626; -.
Phylogenomic databases
HOVERGEN Q6QA33; -.
Other
ProtoNet Q6QA33.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Lipid synthesis; Membrane; NADP; Oxidoreductase; Steroid biosynthesis; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   311  311     Estradiol 17-beta-dehydrogenase 12-B. PRO_0000248372
TRANSMEM   8    28  21     Potential. 
TRANSMEM   125   145  21     Potential. 
TRANSMEM   269   289  21     Potential. 
NP_BIND   48    77  30     NADP (By similarity). 
ACT_SITE   200   200        Proton acceptor (By similarity). 
BINDING   187   187        Substrate (By similarity). 
CONFLICT   2     2        E -> D (in Ref. 1; AAS58450). 
Sequence information
Length: 311 AA [This is the length of the unprocessed precursor] Molecular weight: 34279 Da [This is the MW of the unprocessed precursor] CRC64: 995F46371555BFB4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEPFADALFW VGAVTVLWLS VSSLWSLING IRVWILGNGN LMRASSLGKW AVVTGATDGI 

        70         80         90        100        110        120 
GKAYAEELAR RGFAIVLISR TQEKLDEVSK AIESKYKVET KTISADFGSV DIYPKIESGL 

       130        140        150        160        170        180 
AGLEIGVLVN NVGVSYSYPE FFLNIPDVDS FINNMININI MSVCQMTRLV LPRMVDRSKG 

       190        200        210        220        230        240 
VILNVASASG MYPVPLLTLY SSTKAFVDFF SRGLDAEYKS KGIIIQSVLP FYVTTKLSKI 

       250        260        270        280        290        300 
RKPTLDIPTP ERYVKAQLST IGLQTQSNGY LPHAIMGWVT ASLLPAKLLN KYVMGMGLSQ 

       310 
RARYLKKQKQ G
Q6QA33 in FASTA format

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