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[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND DEVELOPMENTAL STAGE.
DOI=10.1016/S1567-133X(03)00144-3; PubMed=14678836 [NCBI, ExPASy, EBI, Israel, Japan]
Schmidtmer J.,
Engelkamp D.;
"Isolation and expression pattern of three mouse homologues of chick Rgm.";
Gene Expr. Patterns 4:105-110(2004).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
STRAIN=C57BL/6, and FVB/N;
TISSUE=Brain, and Mammary gland;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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- FUNCTION: Repulsive guidance molecules (Rgm) are involved in the guidance of growth cones of the developing neurons.
- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By similarity).
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Isoform ID | Q6PCX7-2 |
| Note: No experimental confirmation available. |
| Features which should be applied to build the isoform sequence: VSP_011316. |
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- TISSUE SPECIFICITY: Expressed in gradient in periventricular layers of the developing nervous system. In adult, expressed in scattered cells throughout the brain.
- DEVELOPMENTAL STAGE: Expressed in the early developing nervous system, with the exception of prominent gaps in the mid-hindbrain and the fore-midbrain boundaries. By E10.5, expression in the nervous system decreases slightly and a segmented pattern of expression appears, marking the ventral sites of somitic buds. At that stage, the expression shows a strong dorsal to ventral gradient. In the neural tubes, strong expression is detected at the level of the floor plate and in the medial portion of the neural tubes. Lower expression is detected in the dorsal neural tube and the ventral aspect corresponding to the area of motoneuron differentiation. In the developing eye, expressed in the perioptic mesenchyme.
- SIMILARITY: Belongs to the repulsive guidance molecule (RGM) family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 454 AA [This is the length of the unprocessed precursor] |
Molecular weight: 49676 Da [This is the MW of the unprocessed precursor] |
CRC64: 3AD1C72D8A70E177 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MQPPRERLVV TGRAGWMGMG RGAGRSALGL WPTLAFLLCS FPAAISPCKI LKCNSEFWSA
70 80 90 100 110 120
TSSGSHAPAS DDVPEFCAAL RTYALCTRRT ARTCRGDLAY HSAVHGIEDL MSQHNCSKDG
130 140 150 160 170 180
PTSQPRVRTL PPAGDSQERS DSPEICHYEK SFHKHSAAPN YTHCGLFGDP HLRTFTDHFQ
190 200 210 220 230 240
TCKVQGAWPL IDNNYLNVQV TNTPVLPGSA ATATSKLTII FKNFQECVDQ KVYQAEMDEL
250 260 270 280 290 300
PSAFADGSKN GGDKHGANSL KITEKVSGQH VEIQAKYIGT TIVVRQVGRY LTFAVRMPEE
310 320 330 340 350 360
VVNAVEDRDS QGLYLCLRGC PLNQQIDFQA FRANAESPRR PAAASPSPVV PETFPYETAV
370 380 390 400 410 420
AKCKEKLPVE DLYYQACVFD LLTTGDVNFT LAAYYALEDG KMLHSNKDKL HLFERTRELP
430 440 450
GAVAAAAAAA TTFPLAPQIL LGTIPLLVLL PVLW
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Q6PCX7 in FASTA format |
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