ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q6NW40


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name RGMB_HUMAN
Primary accession number Q6NW40
Secondary accession number Q8NC92
Integrated into Swiss-Prot on August 16, 2004
Sequence was last modified on August 16, 2004 (Sequence version 2)
Annotations were last modified on    May 5, 2009 (Entry version 40)
Name and origin of the protein
Protein name RGM domain family member B [Precursor]
Synonyms None
Gene name
Name: RGMB
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK074887; BAC11268.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC067736; AAH67736.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00168358; -.
IPI00456736; -.
RefSeq NP_001012779.2; -.
UniGene Hs.526902
3D structure databases
ModBase Q6NW40.
Enzyme and pathway databases
Pathway_Interaction_DB bmppathway; BMP receptor signaling.
Organism-specific databases
GeneCards GC05P098132; -.
HGNC HGNC:26896; RGMB.
GenAtlas RGMB.
HPA HPA016993; -.
PharmGKB PA134868641; -.
Gene expression databases
ArrayExpress Q6NW40; -.
Bgee Q6NW40; -.
CleanEx HS_RGMB; -.
GermOnline ENSG00000174136; Homo sapiens.
Ontologies
GO
GO:0046658; Cellular component: anchored to plasma membrane (inferred from sequence or structural similarity from HGNC).
GO:0005793; Cellular component: ER-Golgi intermediate compartment (inferred from sequence or structural similarity from HGNC).
GO:0042802; Molecular function: identical protein binding (inferred from sequence or structural similarity from HGNC).
GO:0030509; Biological process: BMP signaling pathway (inferred from sequence or structural similarity from HGNC).
GO:0007155; Biological process: cell adhesion (inferred from sequence or structural similarity from HGNC).
GO:0045941; Biological process: positive regulation of transcription (inferred from sequence or structural similarity from HGNC).
QuickGo view.
Family and domain databases
InterPro IPR009496; RGM_C.
IPR010536; RGM_N.
Graphical view of domain structure.
Pfam PF06534; RGM_C; 1.
PF06535; RGM_N; 1.
Pfam graphical view of domain structure.
Proteomic databases
PRIDE Q6NW40; -.
Genome annotation databases
Ensembl ENSG00000174136; Homo sapiens. [Contig view]
GeneID 285704; -.
KEGG hsa:285704; -.
Phylogenomic databases
HOGENOM Q6NW40; -.
HOVERGEN Q6NW40; -.
Other
NextBio 95719; -.
ProtoNet Q6NW40.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    45  45     Potential. 
CHAIN   46   413  368     RGM domain family member B. PRO_0000030394
PROPEP   414   437  24     Removed in mature form (Potential). PRO_0000030395
LIPID   413   413        GPI-anchor amidated asparagine (Potential). 
CARBOHYD   120   120        N-linked (GlcNAc...) (Potential). 
CARBOHYD   383   383        N-linked (GlcNAc...) (Potential). 
VAR_SEQ   216   232        ITIIFKAHHGCTDQKVY -> ASIPSFFPLPTQLSKDV (in isoform 2). VSP_011317
VAR_SEQ   233   437        Missing (in isoform 2). VSP_011318
Sequence information
Length: 437 AA [This is the length of the unprocessed precursor] Molecular weight: 47544 Da [This is the MW of the unprocessed precursor] CRC64: B81604080FFBF0C5 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGLRAAPSSA AAAAAEVEQR RRPGLCPPPL ELLLLLLFSL GLLHAGDCQQ PAQCRIQKCT 

        70         80         90        100        110        120 
TDFVSLTSHL NSAVDGFDSE FCKALRAYAG CTQRTSKACR GNLVYHSAVL GISDLMSQRN 

       130        140        150        160        170        180 
CSKDGPTSST NPEVTHDPCN YHSHAGAREH RRGDQNPPSY LFCGLFGDPH LRTFKDNFQT 

       190        200        210        220        230        240 
CKVEGAWPLI DNNYLSVQVT NVPVVPGSSA TATNKITIIF KAHHGCTDQK VYQAVTDDLP 

       250        260        270        280        290        300 
AAFVDGTTSG GDSDAKSLRI VERESGHYVE MHARYIGTTV FVRQVGRYLT LAIRMPEDLA 

       310        320        330        340        350        360 
MSYEESQDLQ LCVNGCPLSE RIDDGQGQVS AILGHSLPRT SLVQAWPGYT LETANTQCHE 

       370        380        390        400        410        420 
KMPVKDIYFQ SCVFDLLTTG DANFTAAAHS ALEDVEALHP RKERWHIFPS SGNGTPRGGS 

       430 
DLSVSLGLTC LILIVFL 

Q6NW40 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!