NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 15356 / HD100 / DSM 50701 / NCIB 9529;
DOI=10.1126/science.1093027; PubMed=14752164 [NCBI, ExPASy, EBI, Israel, Japan]
Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.;
"A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective.";
Science 303:689-692(2004).

Comments

FUNCTION: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBCELLULAR LOCATION: Cytoplasm (Probable).
SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BX842647; CAE78371.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_967378.1; -.

3D structure databases

ModBase

Q6MQS6.

Enzyme and pathway databases

BioCyc

BBAC264462:BD0384-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0045020;	Biological process: error-prone DNA repair (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01902; -; 1.
PBIL [Tree]

InterPro

IPR011708; DNA_pol3_alpha.
IPR004365; NA_bd_OB_tRNA-helicase.
IPR004013; PHP_C.
IPR003141; PHP_N.
IPR004805; PolC_alpha.
Graphical view of domain structure.

Pfam

PF07733; DNA_pol3_alpha; 1.
PF02811; PHP; 1.
PF01336; tRNA_anti; 1.
Pfam graphical view of domain structure.

SMART

SM00481; POLIIIAc; 1.
SMART graphical view of domain structure.

TIGRFAMs

TIGR00594; polc; 1.

BLOCKS

Q6MQS6.

Genome annotation databases

2733452; -.

BX842601_GR; Bd0384.

bba:Bd0384; -.

fig|264462.1.peg.348; -.

Phylogenomic databases

HOGENOM

Q6MQS6; -.

Genome annotation databases

CMR

Q6MQS6; Bd0384.

Other

ProtoNet

Q6MQS6.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1061`	`1061`		`Error-prone DNA polymerase.`	`PRO_0000103366`

Sequence information

Length: 1061 AA [This is the length of the unprocessed precursor]

Molecular weight: 121567 Da [This is the MW of the unprocessed precursor]

CRC64: C0C592AE67AB3C83 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTNKALIPSQ NSRLPAKPRP RAKGFVELLG RSNFSFLQGA SSPEEMVSQA VEFGYDGMAL 

        70         80         90        100        110        120 
CDLNGLYGVV RGFQTIQSPS LFTASPQVKE NFHYLIGSEL TLTDESSVVL IPMNKQGYSH 

       130        140        150        160        170        180 
LCEILTLGKR QAAKGFSKLS LEQIEKYNQG LLCLALPPWT DERYEKLEKI FDNRLYLPLW 

       190        200        210        220        230        240 
RDLTWESQEF CRQGFALEEK YKAQLFVTQR PFMHSPERKP LFDVLTCTLH HTTLAEAKNK 

       250        260        270        280        290        300 
LIQNSERCLK SLEDISWLWQ DRLDLVEKTV EISARVTFSL NEIRYRYPAS SLPSGMTPTE 

       310        320        330        340        350        360 
YMRHLTLKGA ESRYPEGIPD KALKQIEHEL ELIKDLQYED YFLTLKEICD FASERKILYQ 

       370        380        390        400        410        420 
GRGSAANSVV CFCLGLTAID PVKMDLLFER FLSRERREPP DIDIDFEHSR REEVIQHIYE 

       430        440        450        460        470        480 
KYNERHAAMV CTVIRYRSRM AIRETAKVFG MPLAKINAMI KFMGRDGMKR LLDPAVAADF 

       490        500        510        520        530        540 
GMEPGPWKMF MALAQQLHGF PRHLGIHTGG FLITQDPITE MVPVEKATMN GRYVIQWNKD 

       550        560        570        580        590        600 
DVDFLRLMKI DVLSLGMLTC LRKCFDLLRD VKGRDYSLAT LPADDKPTYD MICRAETVGV 

       610        620        630        640        650        660 
FQIESRAQMN TLPRMQPRNF YDLVIEIALI RPGPLQGGMV HPFLKLRQNP PKEIKYAHPA 

       670        680        690        700        710        720 
LEPILKKTMG IPIFQEQVMK MVVAVADFTP GEADELRRVM SSAWKRKATM GGIEQRLRTG 

       730        740        750        760        770        780 
FARHGISSEY ADQIFKTIEG FANYGFPESH SASFALLTYA SCYLKCHYPD VFACGLLNSQ 

       790        800        810        820        830        840 
PMGFYAPRTI IAEAQRNGVV VAPLDVQKSD YDYTIEKTAA GDLLRVGLRS IYGIPEVLIR 

       850        860        870        880        890        900 
RIEDSRKEEG LYIDLADFIR RTQLPRSVLL KLAAAGAFES FNSNVRELIW NLESLSLDQQ 

       910        920        930        940        950        960 
SFLWGHPKEQ FELGEDDDEP EHLPFESNWD RLRREYDSKG YSVESHPMSV LRTYLHSKSE 

       970        980        990       1000       1010       1020 
ALREKRFVPY FSSEDLKRMK TKTKVRVAGL VAITQRPPTA KGMCFITLED EFGFVNIVIH 

      1030       1040       1050       1060 
PEIYQKDRTT IYTRSLLEIH GQVEKVGAIT NIRAERILPL G

Q6MQS6 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools