FUNCTION: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
CATALYTIC ACTIVITY: Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.
SUBUNIT: Heterodimer of a large subunit and a small subunit (By similarity).
SIMILARITY: Belongs to the archaeal DNA polymerase II family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BX950229; CAF29582.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_987146.1; -.

3D structure databases

ModBase

Q6M191.

Enzyme and pathway databases

BioCyc

MMAR267377:MMP0026-MON; -.

Ontologies

GO:0008408;	Molecular function: 3'-5' exonuclease activity (inferred from electronic annotation from HAMAP).
GO:0003677;	Molecular function: DNA binding (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0000738;	Biological process: DNA catabolic process, exonucleolytic (inferred from electronic annotation from HAMAP).
GO:0006261;	Biological process: DNA-dependent DNA replication (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00324; -; 1.
PBIL [Tree]

InterPro

IPR004475; PolC_DP2.
IPR016033; PolC_DP2_N.
Graphical view of domain structure.

Pfam

PF03833; PolC_DP2; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF016275; PolC_DP2; 1.

TIGRFAMs

TIGR00354; polC; 1.

BLOCKS

Q6M191.

Genome annotation databases

GeneID

2762226; -.

GenomeReviews

BX950229_GR; MMP0026.

KEGG

mmp:MMP0026; -.

NMPDR

fig|267377.1.peg.26; -.

Phylogenomic databases

HOGENOM

Q6M191; -.

Genome annotation databases

CMR

Q6M191; MMP0026.

Other

ProtoNet

Q6M191.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; DNA replication; DNA-binding; DNA-directed DNA polymerase; Exonuclease; Hydrolase; Multifunctional enzyme; Nuclease; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1131`	`1131`		`DNA polymerase II large subunit.`	`PRO_0000294686`

Sequence information

Length: 1131 AA [This is the length of the unprocessed precursor]

Molecular weight: 128381 Da [This is the MW of the unprocessed precursor]

CRC64: 3A000B7DAC5961DE [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLHVSASKGM TEYFKNILDD VSNLYNLAEE CRKNGYDVTD HVEIPLAKDM ADRVEGIVGP 

        70         80         90        100        110        120 
KNVAERIREL VSEFGKEPAA LEIAKEIVEG KFGEFGREVG AEQAVRTALA VITEGIVAAP 

       130        140        150        160        170        180 
LEGIAYVKIK KNSDNSEYLA IYFAGPIRSA GGTAQALAVL VGDYVRKNMG LDRFKPTEDE 

       190        200        210        220        230        240 
VERYGEEVDL YQSEVTTFQY QPKAEEIRVA VRNISVEITG EATDDVEVSG HRDLPRVETN 

       250        260        270        280        290        300 
QIRGGALLAL VEGVLLKAPK ILRHVDKLNI EGWNWLKELK SKKEEVIEEL EEENDEYNYE 

       310        320        330        340        350        360 
DEEDLSQYED YEVEAVTKFI GEVIAGRPVF SHPSKKGGFR LRYGRSRNTG FATDGFHPAI 

       370        380        390        400        410        420 
MYLVDDFMAV GTQLKTERPG KATCVVPVDS IEGPIVKLND GSVLKIDTVE KAKQYTDEVQ 

       430        440        450        460        470        480 
EILFLGDILV NYGDFLENNH TVLPSSWCTE WYEKILKSQN LEYTEEFIKN PGQKEAVNYA 

       490        500        510        520        530        540 
KITKTPLHPK YTYFWHDISK ENISTLRSWV IGGKYNPSND SWELNYDPED EEISNAKRYL 

       550        560        570        580        590        600 
ELIGCPHIVM EEKVEIFEYY PFLYSLGYDF DEKRDMIDNI DEKLQNTKNN MHFINTIAPF 

       610        620        630        640        650        660 
EIRRNAYIYV GARMGRPEKA AARKMKPPVN GLFPIGNAGA LVRLINKAVD EGKTDEIEIA 

       670        680        690        700        710        720 
NVKCSCGKVS LYRTCPFCGN SVEPTGPSRI KLPIKDYWYK TLENLKINKP GDVKCIKGMT 

       730        740        750        760        770        780 
SKDKIIEPLE KAILRAKNNI YVFKDGTTRF DCTDVPVTHF KPVEIHVPIE KLKSLGYLKD 

       790        800        810        820        830        840 
IHGNPLENED QVLELKVQDV IVPESCMDYF LNVSGFIDDL LEKYYKKDRF YNVNTREDLV 

       850        860        870        880        890        900 
GHLIIGMAPH TSAGMVGRII GYSNANVGYA HPYFHASKRR NCDGDEDAFF LLLDAFMNFS 

       910        920        930        940        950        960 
KRFLPDKRGG QMDAPLVLTT ILDPKEVDGE VHNMDSMWEY PLEFYEKSLE GIAPKEIKKM 

       970        980        990       1000       1010       1020 
METIEDRLDK DSQYEGIGYT HETSKIDEGP PICAYKTLGS MMEKTSAQLA VAKKIRATDE 

      1030       1040       1050       1060       1070       1080 
RDVAEKVIQS HFVPDLIGNL RAFSRQGVRC KCGAKYRRMP LKGVCRKCGS RLILTVSKGA 

      1090       1100       1110       1120       1130 
VEKYMNVSQT MAEKYDASDY IKQRLEIIKS GIDSLFVNDK RKQVKIEDFF K

Q6M191 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools