[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=cv. Nipponbare; The international rice genome sequencing project (IRGSP) consortium; "Oryza sativa nipponbare chromosome 2 genomic DNA sequence."; Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=cv. Nipponbare; DOI=10.1126/science.1081288; PubMed=12869764 [NCBI, ExPASy, EBI, Israel, Japan] The rice full-length cDNA consortium; "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."; Science 301:376-379(2003).

Comments

FUNCTION: mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity).
CATALYTIC ACTIVITY: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m₇G(5')pppR-RNA.
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the mRNA cap methyltransferase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AP004257; BAD19434.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AP008208; BAF10219.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AK067608; -; NOT_ANNOTATED_CDS; mRNA.	[EMBL / GenBank / DDBJ]
AK121526; -; NOT_ANNOTATED_CDS; mRNA.	[EMBL / GenBank / DDBJ]

RefSeq

NP_001048305.1; -.

UniGene

Os.10219

3D structure databases

ModBase

Q6K833.

Organism-specific databases

Gramene

Q6K833; -.

Family and domain databases

InterPro

IPR013217; Methyltransf_12.
Graphical view of domain structure.

Pfam

PF08242; Methyltransf_12; 1.
Pfam graphical view of domain structure.

BLOCKS

Q6K833.

Genome annotation databases

GeneID

4330921; -.

KEGG

osa:4330921; -.

Other

ProtoNet

Q6K833.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Methyltransferase; mRNA capping; mRNA processing; Nucleus; RNA-binding; S-adenosyl-L-methionine; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 339`	`339`	`mRNA cap guanine-N7 methyltransferase 2.`	`PRO_0000260153`
`BINDING`	`14 14`		`S-adenosyl-L-methionine (By similarity).`
`BINDING`	`41 41`		`mRNA cap (By similarity).`
`BINDING`	`54 54`		`S-adenosyl-L-methionine (By similarity).`
`BINDING`	`269 269`		`mRNA cap (By similarity).`
`CONFLICT`	`116 116`		`E -> V (in Ref. 2; AK121526).`

Sequence information

Length: 339 AA [This is the length of the unprocessed precursor]

Molecular weight: 38388 Da [This is the MW of the unprocessed precursor]

CRC64: 136DA11E7D0807CB [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAVTPHHRLY EFAKTALIKI FAFPYATVCD LYCDGGVDTD KWGDAQIGHY IGIDASASGV 

        70         80         90        100        110        120 
NDARELWESR KKLFTSEFIE LDPSADDFEA QMQEKGIQAD IVCCMQHLQL CFESEEHAQK 

       130        140        150        160        170        180 
LLNNVSSLLK PGGYFVGIIP DSSTIWTKYQ KNVEASHNKG LKTVPNSIRS ENYVITFEVE 

       190        200        210        220        230        240 
EEKFPFFGKK YQLKFANESM FENHCLVHFP SFMRLAREAG LEYVEIQNLT EFYDDNRTQF 

       250        260        270        280        290        300 
APLLGGYGSS LVDPRGKLVA RSFDILGLYS TFVFQKPDPD AMPPIVTPEL HDPENDQEEE 

       310        320        330 
WLWTQQASMD DGRVSRTDIL PPADNEKGIL GPGPADMRL

Q6K833 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools