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UniProtKB/Swiss-Prot entry Q6ISS4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LAIR2_HUMAN
Primary accession number Q6ISS4
Secondary accession number Q6PEZ4
Integrated into Swiss-Prot on October 3, 2006
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 45)
Name and origin of the protein
Protein name Leukocyte-associated immunoglobulin-like receptor 2 [Precursor]
Synonyms LAIR-2
CD306 antigen
Gene name
Name: LAIR2
Synonyms: CD306
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
DOI=10.1016/S1074-7613(00)80530-0; PubMed=9285412 [NCBI, ExPASy, EBI, Israel, Japan]
Meyaard L., Adema G.J., Chang C., Woollatt E., Sutherland G.R., Lanier L.L., Phillips J.H.;
"LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes.";
Immunity 7:283-290(1997).
[2]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=10229813 [NCBI, ExPASy, EBI, Israel, Japan]
Meyaard L., Hurenkamp J., Clevers H., Lanier L.L., Phillips J.H.;
"Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells.";
J. Immunol. 162:5800-5804(1999).
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF013250; AAB69325.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AA133246; -; NOT_ANNOTATED_CDS; mRNA.[EMBL / GenBank / DDBJ]
BC069366; AAH69366.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00010137; -.
IPI00032545; -.
RefSeq NP_002279.2; -.
NP_067154.1; -.
UniGene Hs.43803
3D structure databases
ModBase Q6ISS4.
Organism-specific databases
GeneCards GC19P059705; -.
HGNC HGNC:6478; LAIR2.
GenAtlas LAIR2.
MIM 602993; gene. [NCBI / EBI]
PharmGKB PA30267; -.
Gene expression databases
ArrayExpress Q6ISS4; -.
Bgee Q6ISS4; -.
CleanEx HS_LAIR2; -.
GermOnline ENSG00000167618; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004872; Molecular function: receptor activity (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.10; Ig-like_fold; 1.
SMART SM00409; IG; 1.
SMART graphical view of domain structure.
PROSITE PS50835; IG_LIKE; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
Ensembl ENSG00000167618; Homo sapiens. [Contig view]
GeneID 3904; -.
KEGG hsa:3904; -.
Phylogenomic databases
HOVERGEN Q6ISS4; -.
OMA Q6ISS4; FRLGPSE.
Other
NextBio 15327; -.
SOURCE LAIR2; Homo sapiens.
ProtoNet Q6ISS4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Disulfide bond; Immunoglobulin domain; Polymorphism; Receptor; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    21  21     Potential. 
CHAIN   22   152  131     Leukocyte-associated immunoglobulin-like receptor 2. PRO_0000250685
DOMAIN   29   117  89     Ig-like C2-type. 
DISULFID   49   101        By similarity. 
VAR_SEQ   122   138        Missing (in isoform 2). VSP_020720
VARIANT   78    78  1     G -> S (in dbSNP:rs36121405 [NCBI]). VAR_049882 
VARIANT   87    87  1     H -> R (in dbSNP:rs34423078 [NCBI]). VAR_049883 
VARIANT   115   115  1     F -> Y (in dbSNP:rs34429135 [NCBI]). VAR_049884 
Sequence information
Length: 152 AA [This is the length of the unprocessed precursor] Molecular weight: 16280 Da [This is the MW of the unprocessed precursor] CRC64: 8097688A9DB42EC8 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSPHLTALLG LVLCLAQTIH TQEGALPRPS ISAEPGTVIS PGSHVTFMCR GPVGVQTFRL 

        70         80         90        100        110        120 
EREDRAKYKD SYNVFRLGPS ESEARFHIDS VSEGNAGLYR CLYYKPPGWS EHSDFLELLV 

       130        140        150 
KESSGGPDSP DTEPGSSAGT VPGTEASGFD AP
Q6ISS4 in FASTA format

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