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UniProtKB/Swiss-Prot entry Q6GGZ4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ARLS_STAAR
Primary accession number Q6GGZ4
Secondary accession numbers None
Integrated into Swiss-Prot on June 7, 2005
Sequence was last modified on July 19, 2004 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 37)
Name and origin of the protein
Protein name Signal transduction histidine-protein kinase arlS
Synonym EC 2.7.13.3
Gene name
Name: arlS
OrderedLocusNames: SAR1426
From
Staphylococcus aureus (strain MRSA252) [TaxID: 282458] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0402521101; PubMed=15213324 [NCBI, ExPASy, EBI, Israel, Japan]
Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.";
Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX571856; CAG40423.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_040828.1; -.
3D structure databases
ModBase Q6GGZ4.
Enzyme and pathway databases
BioCyc SAUR282458:SAR1426-MON; -.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0009405; Biological process: pathogenesis (inferred from electronic annotation from UniProtKB-KW).
GO:0000160; Biological process: two-component signal transduction system (phosphorelay) (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR003594; ATP_bd_ATPase.
IPR004358; Sig_transdc_His_kin-like_C.
IPR003661; Sig_transdc_His_kin_sub1_dim/P.
IPR005467; Sig_transdc_His_kinase_core.
IPR003660; Sig_transdc_His_kinase_HAMP.
Graphical view of domain structure.
Gene3D G3DSA:3.30.565.10; ATP_bd_ATPase; 1.
Pfam PF00672; HAMP; 1.
PF02518; HATPase_c; 1.
PF00512; HisKA; 1.
Pfam graphical view of domain structure.
PRINTS PR00344; BCTRLSENSOR.
SMART SM00304; HAMP; 1.
SM00387; HATPase_c; 1.
SM00388; HisKA; 1.
SMART graphical view of domain structure.
PROSITE PS50885; HAMP; 1.
PS50109; HIS_KIN; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q6GGZ4.
ProtoNet Q6GGZ4.
Genome annotation databases
GeneID 2859859; -.
GenomeReviews BX571856_GR; SAR1426.
KEGG sar:SAR1426; -.
Phylogenomic databases
HOGENOM Q6GGZ4; -.
Genome annotation databases
CMR Q6GGZ4; SAR1426.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Complete proteome; Kinase; Membrane; Phosphoprotein; Transferase; Transmembrane; Two-component regulatory system; Virulence.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   451  451     Signal transduction histidine-protein kinase arlS. PRO_0000074692
TRANSMEM   11    31  21     Potential. 
TRANSMEM   156   176  21     Potential. 
DOMAIN   178   231  54     HAMP. 
DOMAIN   239   451  213     Histidine kinase. 
MOD_RES   242   242        Phosphohistidine; by autocatalysis (By similarity). 
Sequence information
Length: 451 AA [This is the length of the unprocessed precursor] Molecular weight: 52386 Da [This is the MW of the unprocessed precursor] CRC64: F3D99C9F42B371E2 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTKRKLRNNW IIVTTMITFV TIFLFCLIII FFLKDTLHNS ELDDAERSSS DINNLFHSKP 

        70         80         90        100        110        120 
VKDISALDLN ASLGNFQEII IYDEHNNKLF ETSNDNTVRV EPGYEHRYFD RVIKKRYKGI 

       130        140        150        160        170        180 
DYLIIKEPIT TQDFKGYSLL IHSLENYDNI VKSLYIIALA FGVIATIITA TISYVFSTQI 

       190        200        210        220        230        240 
TKPLVSLSNK MIEIRRDGFQ NKLQLNTNYE EIDNLANTFN EMMSQIEESF NQQRQFVEDA 

       250        260        270        280        290        300 
SHELRTPLQI IQGHLNLIQR WGKKDPAVLE ESLNISIEEM NRIIKLVEEL LELTKGDVND 

       310        320        330        340        350        360 
ISSEAQTVHI NDEIRSRIHS LKQLHPDYQF DTDLTSKNLE IKMKPHQFEQ LFLIFIDNAI 

       370        380        390        400        410        420 
KYDVKNKKIK VKTRLKNKQK IIEITDHGIG IPEEDQDFIF DRFYRVDKSR SRSQGGNGLG 

       430        440        450 
LSIAQKIIQL NGGSIKIKSE INKGTTFKII F 

Q6GGZ4 in FASTA format

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