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UniProtKB/Swiss-Prot entry Q6GFE8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SSPP_STAAR
Primary accession number Q6GFE8
Secondary accession numbers None
Integrated into Swiss-Prot on July 5, 2005
Sequence was last modified on July 19, 2004 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 24)
Name and origin of the protein
Protein name Staphopain A [Precursor]
Synonyms EC 3.4.22.48
Staphylopain A
Staphylococcal cysteine proteinase A
Gene name
Name: sspP
Synonyms: scpA
OrderedLocusNames: SAR2001
From
Staphylococcus aureus (strain MRSA252) [TaxID: 282458] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0402521101; PubMed=15213324 [NCBI, ExPASy, EBI, Israel, Japan]
Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.";
Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX571856; CAG40986.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_041374.1; -.
3D structure databases
SMR Q6GFE8; 216-388.
ModBase Q6GFE8.
Enzyme and pathway databases
BioCyc SAUR282458:SAR2001-MON; -.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0009405; Biological process: pathogenesis (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000169; Pept_cys_AS.
IPR008750; Peptidase_C47.
Graphical view of domain structure.
Pfam PF05543; Peptidase_C47; 1.
Pfam graphical view of domain structure.
PROSITE PS00640; THIOL_PROTEASE_ASN; FALSE_NEG.
PS00139; THIOL_PROTEASE_CYS; FALSE_NEG.
PS00639; THIOL_PROTEASE_HIS; 1.
BLOCKS Q6GFE8.
ProtoNet Q6GFE8.
Genome annotation databases
GeneID 2859733; -.
GenomeReviews BX571856_GR; SAR2001.
KEGG sar:SAR2001; -.
Phylogenomic databases
HOGENOM Q6GFE8; -.
Genome annotation databases
CMR Q6GFE8; SAR2001.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Protease; Secreted; Signal; Thiol protease; Virulence; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    25  25     Potential. 
PROPEP   26   214  189     By similarity. PRO_0000026553
CHAIN   215   388  174     Staphopain A. PRO_0000026554
ACT_SITE   238   238        By similarity. 
ACT_SITE   334   334        By similarity. 
ACT_SITE   355   355        By similarity. 
SITE   214   215  2     Cleavage (By similarity). 
Sequence information
Length: 388 AA [This is the length of the unprocessed precursor] Molecular weight: 44048 Da [This is the MW of the unprocessed precursor] CRC64: 44017EA70E289F14 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKRNFPKLIA LSLIFSLSIT PIANAESNSN IKAKDKRHVQ VNVEDKSVPT DVRNLAQKDY 

        70         80         90        100        110        120 
LSYVTSLDKI YNKEKASYTL GEPFKIYKFN KKSDGNYYFP VLNTEGNIDY IVTISPKVTK 

       130        140        150        160        170        180 
DSSSSSKYTI NVSSFLSKAL NEYKDQQITI LTNSKGYYVV TQNHKAKLVL KTPRLEDKKA 

       190        200        210        220        230        240 
KKTESIPTGN NVTQLKQKAS VTMPTSQFKS NNYTYNEQYV NKLENFKIRE TQGNNGWCAG 

       250        260        270        280        290        300 
YTMSALLNAT YNTNKYHAEA VMRFLHPNLQ GQQFQFTGLT PREMIYFGQT QGRSPQLLNR 

       310        320        330        340        350        360 
MTTYNEVDNL TKNNKGIAIL GSRVESRNGM HAGHAMAVVG NAKLNNGQEV IIIWNPWDNG 

       370        380 
FMTQDAKNNV IPVSNGDHYQ WYSSIYGY 

Q6GFE8 in FASTA format

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